Progesterone Increases Systemic and Local Uterine Proportions of CD4+CD25+ Treg Cells during Midterm Pregnancy in Mice

Mechanisms maintaining the growth of a “semi-foreign” fetus within the maternal uterus via immune tolerance remain unclear. CD4+CD25+ regulatory T (Treg) cells have been implicated in the maintenance of maternal-fetal immune tolerance. Additionally, 17β-estradiol (E2) is able to initiate immune supp...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Endocrinology (Philadelphia) 2010-11, Vol.151 (11), p.5477-5488
Hauptverfasser:	Mao, Guanping, Wang, Junpeng, Kang, Youmin, Tai, Ping, Wen, Jing, Zou, Qiang, Li, Ge, Ouyang, Hong, Xia, Guoliang, Wang, Bin
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Animal models Animals Biological and medical sciences Blotting, Western CD25 antigen CD4 antigen Cell culture Cells, Cultured Estradiol - analogs & derivatives Estradiol - blood Estradiol - pharmacology Female Fetuses Foxp3 protein Fundamental and applied biological sciences. Psychology Immunological tolerance Lymphocyte Count Lymphocytes Lymphocytes T Maternal effects Mice Mifepristone - pharmacology Ovariectomy Pregnancy Progesterone Progesterone - blood Progesterone - pharmacology Pseudopregnancy Radioimmunoassay Receptor mechanisms Receptors Sex hormones T-Lymphocytes, Regulatory - cytology T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology Uterus Uterus - cytology Uterus - drug effects Uterus - immunology Vertebrates: endocrinology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!