Malignant melanoma of the conjunctiva
One hundred thirty-one cases of conjunctival melanoma in which biopsies had been performed were studied to determine potential factors that might affect outcome in patients with these lesions. Two greups of lesions were identified: those associated with primary acquired melanosis (melanoma with PAM,...
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| Veröffentlicht in: | Human pathology 1985-02, Vol.16 (2), p.136-143 |
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| creator | Folberg, Robert McLean, Ian W. Zimmerman, Lorenz E. |
| description | One hundred thirty-one cases of conjunctival melanoma in which biopsies had been performed were studied to determine potential factors that might affect outcome in patients with these lesions. Two greups of lesions were identified: those associated with primary acquired melanosis (melanoma with PAM, 98 cases, 74.8 per cent) and those without primary acquired melanosis (melanoma without PAM, 33 cases, 25.2 per cent). The overall mortality rate in the 131 cases was 26 per cent (34 of 131); the mortality rate due to melanoma with PAM was 25.5 per cent (25 of 98), and that due to melanoma without PAM was 27.3 per cent (9 of 33). If PAM was associated with the lesion, the presence of atypical melanocytes within the epithelium (pagetoid invasion) was a sensitive indicator of subsequent metastasis. Tumor thickness may also be useful for predicting subsequent metastases. None of the histologic parameters studied proved useful for predicting outcome in patients who had melanomas without PAM. The presence or absence of nevi had no effect on prognosis. |
| doi_str_mv | 10.1016/S0046-8177(85)80062-9 |
| format | Article |
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Two greups of lesions were identified: those associated with primary acquired melanosis (melanoma with PAM, 98 cases, 74.8 per cent) and those without primary acquired melanosis (melanoma without PAM, 33 cases, 25.2 per cent). The overall mortality rate in the 131 cases was 26 per cent (34 of 131); the mortality rate due to melanoma with PAM was 25.5 per cent (25 of 98), and that due to melanoma without PAM was 27.3 per cent (9 of 33). If PAM was associated with the lesion, the presence of atypical melanocytes within the epithelium (pagetoid invasion) was a sensitive indicator of subsequent metastasis. Tumor thickness may also be useful for predicting subsequent metastases. None of the histologic parameters studied proved useful for predicting outcome in patients who had melanomas without PAM. The presence or absence of nevi had no effect on prognosis.</description><identifier>ISSN: 0046-8177</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1016/S0046-8177(85)80062-9</identifier><identifier>PMID: 3972396</identifier><identifier>CODEN: HPCQA4</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Biopsy ; Conjunctiva - pathology ; Conjunctival Diseases - pathology ; Conjunctival Neoplasms - mortality ; Conjunctival Neoplasms - pathology ; Conjunctival Neoplasms - surgery ; Female ; Follow-Up Studies ; Humans ; Male ; Medical sciences ; Melanoma - mortality ; Melanoma - pathology ; Melanoma - surgery ; Melanosis - pathology ; Middle Aged ; Neoplasm Metastasis ; Neoplasm Recurrence, Local ; Ophthalmology ; Prognosis ; Time Factors ; Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus</subject><ispartof>Human pathology, 1985-02, Vol.16 (2), p.136-143</ispartof><rights>1985 W. 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Saunders Co.</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-b919bc0ca8487a32ebf987f7b18e399b118d2153539549b8e3e6913262304a553</citedby><cites>FETCH-LOGICAL-c389t-b919bc0ca8487a32ebf987f7b18e399b118d2153539549b8e3e6913262304a553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0046-8177(85)80062-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9018131$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3972396$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Folberg, Robert</creatorcontrib><creatorcontrib>McLean, Ian W.</creatorcontrib><creatorcontrib>Zimmerman, Lorenz E.</creatorcontrib><title>Malignant melanoma of the conjunctiva</title><title>Human pathology</title><addtitle>Hum Pathol</addtitle><description>One hundred thirty-one cases of conjunctival melanoma in which biopsies had been performed were studied to determine potential factors that might affect outcome in patients with these lesions. Two greups of lesions were identified: those associated with primary acquired melanosis (melanoma with PAM, 98 cases, 74.8 per cent) and those without primary acquired melanosis (melanoma without PAM, 33 cases, 25.2 per cent). The overall mortality rate in the 131 cases was 26 per cent (34 of 131); the mortality rate due to melanoma with PAM was 25.5 per cent (25 of 98), and that due to melanoma without PAM was 27.3 per cent (9 of 33). If PAM was associated with the lesion, the presence of atypical melanocytes within the epithelium (pagetoid invasion) was a sensitive indicator of subsequent metastasis. Tumor thickness may also be useful for predicting subsequent metastases. None of the histologic parameters studied proved useful for predicting outcome in patients who had melanomas without PAM. The presence or absence of nevi had no effect on prognosis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Conjunctiva - pathology</subject><subject>Conjunctival Diseases - pathology</subject><subject>Conjunctival Neoplasms - mortality</subject><subject>Conjunctival Neoplasms - pathology</subject><subject>Conjunctival Neoplasms - surgery</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Melanoma - mortality</subject><subject>Melanoma - pathology</subject><subject>Melanoma - surgery</subject><subject>Melanosis - pathology</subject><subject>Middle Aged</subject><subject>Neoplasm Metastasis</subject><subject>Neoplasm Recurrence, Local</subject><subject>Ophthalmology</subject><subject>Prognosis</subject><subject>Time Factors</subject><subject>Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EKqXwCZW6AASLgCeOE3uFUMVLKmIBrC3HmYCrPIqdVOLvcduoW1Yjec7MXB9CpkBvgEJ6-05pkkYCsuxK8GtBaRpH8oCMgbM4EkzGh2S8R47JifdLSgF4wkdkxGQWM5mOycWrruxXo5tuVmOlm7bWs7acdd84M22z7BvT2bU-JUelrjyeDXVCPh8fPubP0eLt6WV-v4gME7KLcgkyN9RokYhMsxjzUoqszHIQyKTMAUQRh3ycSZ7IPDxiKoHFacxoojlnE3K527ty7U-PvlO19QarEAzb3quMh31AWQD5DjSu9d5hqVbO1tr9KqBqo0dt9ajN35XgaqtHyTA3HQ70eY3FfmrwEfrnQ197o6vS6cZYv8ckBQEMAna3wzDIWFt0yhuLjcHCOjSdKlr7T5A_xqd-qA</recordid><startdate>198502</startdate><enddate>198502</enddate><creator>Folberg, Robert</creator><creator>McLean, Ian W.</creator><creator>Zimmerman, Lorenz E.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198502</creationdate><title>Malignant melanoma of the conjunctiva</title><author>Folberg, Robert ; McLean, Ian W. ; Zimmerman, Lorenz E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-b919bc0ca8487a32ebf987f7b18e399b118d2153539549b8e3e6913262304a553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Conjunctiva - pathology</topic><topic>Conjunctival Diseases - pathology</topic><topic>Conjunctival Neoplasms - mortality</topic><topic>Conjunctival Neoplasms - pathology</topic><topic>Conjunctival Neoplasms - surgery</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Melanoma - mortality</topic><topic>Melanoma - pathology</topic><topic>Melanoma - surgery</topic><topic>Melanosis - pathology</topic><topic>Middle Aged</topic><topic>Neoplasm Metastasis</topic><topic>Neoplasm Recurrence, Local</topic><topic>Ophthalmology</topic><topic>Prognosis</topic><topic>Time Factors</topic><topic>Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Folberg, Robert</creatorcontrib><creatorcontrib>McLean, Ian W.</creatorcontrib><creatorcontrib>Zimmerman, Lorenz E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Folberg, Robert</au><au>McLean, Ian W.</au><au>Zimmerman, Lorenz E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Malignant melanoma of the conjunctiva</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>1985-02</date><risdate>1985</risdate><volume>16</volume><issue>2</issue><spage>136</spage><epage>143</epage><pages>136-143</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><coden>HPCQA4</coden><abstract>One hundred thirty-one cases of conjunctival melanoma in which biopsies had been performed were studied to determine potential factors that might affect outcome in patients with these lesions. Two greups of lesions were identified: those associated with primary acquired melanosis (melanoma with PAM, 98 cases, 74.8 per cent) and those without primary acquired melanosis (melanoma without PAM, 33 cases, 25.2 per cent). The overall mortality rate in the 131 cases was 26 per cent (34 of 131); the mortality rate due to melanoma with PAM was 25.5 per cent (25 of 98), and that due to melanoma without PAM was 27.3 per cent (9 of 33). If PAM was associated with the lesion, the presence of atypical melanocytes within the epithelium (pagetoid invasion) was a sensitive indicator of subsequent metastasis. Tumor thickness may also be useful for predicting subsequent metastases. None of the histologic parameters studied proved useful for predicting outcome in patients who had melanomas without PAM. The presence or absence of nevi had no effect on prognosis.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>3972396</pmid><doi>10.1016/S0046-8177(85)80062-9</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0046-8177 |
| ispartof | Human pathology, 1985-02, Vol.16 (2), p.136-143 |
| issn | 0046-8177 1532-8392 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent Adult Aged Biological and medical sciences Biopsy Conjunctiva - pathology Conjunctival Diseases - pathology Conjunctival Neoplasms - mortality Conjunctival Neoplasms - pathology Conjunctival Neoplasms - surgery Female Follow-Up Studies Humans Male Medical sciences Melanoma - mortality Melanoma - pathology Melanoma - surgery Melanosis - pathology Middle Aged Neoplasm Metastasis Neoplasm Recurrence, Local Ophthalmology Prognosis Time Factors Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus |
| title | Malignant melanoma of the conjunctiva |
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