The activity of a 70 kilodalton IκB molecule identical to the carboxyl terminus of the p105 NF-κB precursor is modulated by protein kinase A

The p50 subunit of NF-kappa B is derived from the amino terminus of a 105 kilodalton precursor. The p105 carboxyl terminus, which contains ankyrin-like repeats, a feature of I kappa B molecules, regulates the cytoplasmic retention of p105 and inhibits DNA binding by the precursor. Here, we describe...

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