Dobutamine stress–Doppler echocardiography before and after coronary angioplasty
To determine if dobutamine-induced myocardial ischaemia causes abnormalities in Doppler parameters of left ventricular ejection and filling and to assess early effects of successful coronary angioplasty (PTCA) on these parameters, dobutamine stress echocardiography and Doppler studies were performed...
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| Veröffentlicht in: | European heart journal 1993-08, Vol.14 (8), p.1011-1021 |
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| creator | EL-SAID, E. S. M. FIORETTI, P. M. ROELANDT, J. R. T. C. MCNEILL, A. J. RIJSTERBORGH, H. FORSTER, T. DI MARIO, C. LINKER, D. T. |
| description | To determine if dobutamine-induced myocardial ischaemia causes abnormalities in Doppler parameters of left ventricular ejection and filling and to assess early effects of successful coronary angioplasty (PTCA) on these parameters, dobutamine stress echocardiography and Doppler studies were performed once in 11 normal volunteers and twice in 17 patients (within 1 day pre- and post-PTCA). Dobutamine induced wall motion abnormalities, ST changes and angina in 11, five and five patients, respectively, before and three, two and one patients. respectively, after PTCA. Doppler indices of both systolic and diastolic function were comparable at rest, before and after PTCA. Dobutamine induced similar increases in peak aortic velocity and average acceleration in healthy individuals (39% and 53%) and in patients with one-vessel disease both before (38% and 39%) and after PTCA (39% and 40%). In the three patients with multivessel disease, peak aortic velocity showed a blunted response (−0.3%) before PTCA but increased by 17% after PTCA, while acceleration decreased both before (12%) and after PTCA (14%). There were significant differences (P |
| doi_str_mv | 10.1093/eurheartj/14.8.1011 |
| format | Article |
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S. M. ; FIORETTI, P. M. ; ROELANDT, J. R. T. C. ; MCNEILL, A. J. ; RIJSTERBORGH, H. ; FORSTER, T. ; DI MARIO, C. ; LINKER, D. T.</creator><creatorcontrib>EL-SAID, E. S. M. ; FIORETTI, P. M. ; ROELANDT, J. R. T. C. ; MCNEILL, A. J. ; RIJSTERBORGH, H. ; FORSTER, T. ; DI MARIO, C. ; LINKER, D. T.</creatorcontrib><description>To determine if dobutamine-induced myocardial ischaemia causes abnormalities in Doppler parameters of left ventricular ejection and filling and to assess early effects of successful coronary angioplasty (PTCA) on these parameters, dobutamine stress echocardiography and Doppler studies were performed once in 11 normal volunteers and twice in 17 patients (within 1 day pre- and post-PTCA). Dobutamine induced wall motion abnormalities, ST changes and angina in 11, five and five patients, respectively, before and three, two and one patients. respectively, after PTCA. Doppler indices of both systolic and diastolic function were comparable at rest, before and after PTCA. Dobutamine induced similar increases in peak aortic velocity and average acceleration in healthy individuals (39% and 53%) and in patients with one-vessel disease both before (38% and 39%) and after PTCA (39% and 40%). In the three patients with multivessel disease, peak aortic velocity showed a blunted response (−0.3%) before PTCA but increased by 17% after PTCA, while acceleration decreased both before (12%) and after PTCA (14%). There were significant differences (P<0.0001) between healthy individuals and pre-PTCA patients in the effect of dobutamine on peak early (E) filling velocity (+34% vs −19%), E-acceleration (+ 35% vs −26%), peak early to atrial filling velocity ratio (E/A) (−0.7% vs − 37%) and diastolic time velocity integral (TVI) (+ 34% vs −22%). After PTCA, the response of Doppler diastolic indices improved during dobutamine, as shown by the increase in E and E-acceleration (+ 8%, + 24%, respectively) and by the decline in the reduction of E/A and TVI (−17% and −10%, respectively). Thus, the response of Doppler diastolic parameters to dobutamine stress is a sensitive indicator of significant coronary disease and is superior to changes in ejection indices. 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S. M.</creatorcontrib><creatorcontrib>FIORETTI, P. M.</creatorcontrib><creatorcontrib>ROELANDT, J. R. T. C.</creatorcontrib><creatorcontrib>MCNEILL, A. J.</creatorcontrib><creatorcontrib>RIJSTERBORGH, H.</creatorcontrib><creatorcontrib>FORSTER, T.</creatorcontrib><creatorcontrib>DI MARIO, C.</creatorcontrib><creatorcontrib>LINKER, D. T.</creatorcontrib><title>Dobutamine stress–Doppler echocardiography before and after coronary angioplasty</title><title>European heart journal</title><addtitle>Eur Heart J</addtitle><description>To determine if dobutamine-induced myocardial ischaemia causes abnormalities in Doppler parameters of left ventricular ejection and filling and to assess early effects of successful coronary angioplasty (PTCA) on these parameters, dobutamine stress echocardiography and Doppler studies were performed once in 11 normal volunteers and twice in 17 patients (within 1 day pre- and post-PTCA). Dobutamine induced wall motion abnormalities, ST changes and angina in 11, five and five patients, respectively, before and three, two and one patients. respectively, after PTCA. Doppler indices of both systolic and diastolic function were comparable at rest, before and after PTCA. Dobutamine induced similar increases in peak aortic velocity and average acceleration in healthy individuals (39% and 53%) and in patients with one-vessel disease both before (38% and 39%) and after PTCA (39% and 40%). In the three patients with multivessel disease, peak aortic velocity showed a blunted response (−0.3%) before PTCA but increased by 17% after PTCA, while acceleration decreased both before (12%) and after PTCA (14%). There were significant differences (P<0.0001) between healthy individuals and pre-PTCA patients in the effect of dobutamine on peak early (E) filling velocity (+34% vs −19%), E-acceleration (+ 35% vs −26%), peak early to atrial filling velocity ratio (E/A) (−0.7% vs − 37%) and diastolic time velocity integral (TVI) (+ 34% vs −22%). After PTCA, the response of Doppler diastolic indices improved during dobutamine, as shown by the increase in E and E-acceleration (+ 8%, + 24%, respectively) and by the decline in the reduction of E/A and TVI (−17% and −10%, respectively). Thus, the response of Doppler diastolic parameters to dobutamine stress is a sensitive indicator of significant coronary disease and is superior to changes in ejection indices. Successful PTCA resulted in an improved diastolic filling response to dobutamine stress.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Angina Pectoris - diagnostic imaging</subject><subject>Angina Pectoris - therapy</subject><subject>Angioplasty, Balloon, Coronary</subject><subject>Biological and medical sciences</subject><subject>Blood Flow Velocity - drug effects</subject><subject>Blood Flow Velocity - physiology</subject><subject>Cardiovascular system</subject><subject>Coronary angioplasty</subject><subject>Coronary Disease - diagnostic imaging</subject><subject>Coronary Disease - therapy</subject><subject>Diastole - drug effects</subject><subject>Diastole - physiology</subject><subject>diastolic function</subject><subject>Dobutamine</subject><subject>Echocardiography, Doppler - drug effects</subject><subject>Exercise Test - drug effects</subject><subject>Female</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Contraction - drug effects</subject><subject>Myocardial Contraction - physiology</subject><subject>Myocardial Infarction - diagnostic imaging</subject><subject>Myocardial Infarction - therapy</subject><subject>Myocardial Ischemia - diagnostic imaging</subject><subject>Myocardial Ischemia - therapy</subject><subject>Reference Values</subject><subject>stress Doppler</subject><subject>stress echocardiography</subject><subject>Systole - drug effects</subject><subject>Systole - physiology</subject><subject>systolic function</subject><subject>Ultrasonic investigative techniques</subject><subject>Ventricular Function, Left - drug effects</subject><subject>Ventricular Function, Left - physiology</subject><issn>1522-9645</issn><issn>0195-668X</issn><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1KHEEUhYtgMKPmCUKgF5Jda_3_LIOTiYISjQpDNsWd6iqnTU9XW9UNmZ3vkDf0SexhhlldOOc7h8tB6AvBZwQbdu6HtPSQ-udzws_0qBHyAU0wMaKUUs8P0IQISksjufiEjnJ-xhhrSeQhOtQcc8PwBP2exsXQw6pufZH75HN-e_0_jV3X-FR4t4wOUlXHpwTdcl0sfIjJF9BWBYR-JFxMsYW0HqWnOnYN5H59gj4GaLL_vLvH6HH24-Hisrz-9fPq4vt16ZhUfakqt6CgHWeBcTCSySAlUCwwFQ6kAl2Bq4RSjDodnGBADfVYmUpWgpPAjtG3bW-X4svgc29XdXa-aaD1cchWCaOFonIE2RZ0KeacfLBdqlfj15Zgu1nS7pe0hFttN0uOqa-7-mGx8tU-s5tu9E93PmQHTUjQujrvMa61IGaDlVuszr3_t7ch_bVSMSXs5fyPvZ2y-5s7NbNz9g4A3ZB4</recordid><startdate>19930801</startdate><enddate>19930801</enddate><creator>EL-SAID, E. S. M.</creator><creator>FIORETTI, P. M.</creator><creator>ROELANDT, J. R. T. C.</creator><creator>MCNEILL, A. J.</creator><creator>RIJSTERBORGH, H.</creator><creator>FORSTER, T.</creator><creator>DI MARIO, C.</creator><creator>LINKER, D. T.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930801</creationdate><title>Dobutamine stress–Doppler echocardiography before and after coronary angioplasty</title><author>EL-SAID, E. S. M. ; FIORETTI, P. M. ; ROELANDT, J. R. T. C. ; MCNEILL, A. J. ; RIJSTERBORGH, H. ; FORSTER, T. ; DI MARIO, C. ; LINKER, D. 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S. M.</creatorcontrib><creatorcontrib>FIORETTI, P. M.</creatorcontrib><creatorcontrib>ROELANDT, J. R. T. C.</creatorcontrib><creatorcontrib>MCNEILL, A. J.</creatorcontrib><creatorcontrib>RIJSTERBORGH, H.</creatorcontrib><creatorcontrib>FORSTER, T.</creatorcontrib><creatorcontrib>DI MARIO, C.</creatorcontrib><creatorcontrib>LINKER, D. T.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>EL-SAID, E. S. M.</au><au>FIORETTI, P. M.</au><au>ROELANDT, J. R. T. C.</au><au>MCNEILL, A. J.</au><au>RIJSTERBORGH, H.</au><au>FORSTER, T.</au><au>DI MARIO, C.</au><au>LINKER, D. T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dobutamine stress–Doppler echocardiography before and after coronary angioplasty</atitle><jtitle>European heart journal</jtitle><addtitle>Eur Heart J</addtitle><date>1993-08-01</date><risdate>1993</risdate><volume>14</volume><issue>8</issue><spage>1011</spage><epage>1021</epage><pages>1011-1021</pages><issn>1522-9645</issn><issn>0195-668X</issn><eissn>0195-668X</eissn><eissn>1522-9645</eissn><abstract>To determine if dobutamine-induced myocardial ischaemia causes abnormalities in Doppler parameters of left ventricular ejection and filling and to assess early effects of successful coronary angioplasty (PTCA) on these parameters, dobutamine stress echocardiography and Doppler studies were performed once in 11 normal volunteers and twice in 17 patients (within 1 day pre- and post-PTCA). Dobutamine induced wall motion abnormalities, ST changes and angina in 11, five and five patients, respectively, before and three, two and one patients. respectively, after PTCA. Doppler indices of both systolic and diastolic function were comparable at rest, before and after PTCA. Dobutamine induced similar increases in peak aortic velocity and average acceleration in healthy individuals (39% and 53%) and in patients with one-vessel disease both before (38% and 39%) and after PTCA (39% and 40%). In the three patients with multivessel disease, peak aortic velocity showed a blunted response (−0.3%) before PTCA but increased by 17% after PTCA, while acceleration decreased both before (12%) and after PTCA (14%). There were significant differences (P<0.0001) between healthy individuals and pre-PTCA patients in the effect of dobutamine on peak early (E) filling velocity (+34% vs −19%), E-acceleration (+ 35% vs −26%), peak early to atrial filling velocity ratio (E/A) (−0.7% vs − 37%) and diastolic time velocity integral (TVI) (+ 34% vs −22%). After PTCA, the response of Doppler diastolic indices improved during dobutamine, as shown by the increase in E and E-acceleration (+ 8%, + 24%, respectively) and by the decline in the reduction of E/A and TVI (−17% and −10%, respectively). Thus, the response of Doppler diastolic parameters to dobutamine stress is a sensitive indicator of significant coronary disease and is superior to changes in ejection indices. Successful PTCA resulted in an improved diastolic filling response to dobutamine stress.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>8404930</pmid><doi>10.1093/eurheartj/14.8.1011</doi><tpages>11</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Angina Pectoris - diagnostic imaging Angina Pectoris - therapy Angioplasty, Balloon, Coronary Biological and medical sciences Blood Flow Velocity - drug effects Blood Flow Velocity - physiology Cardiovascular system Coronary angioplasty Coronary Disease - diagnostic imaging Coronary Disease - therapy Diastole - drug effects Diastole - physiology diastolic function Dobutamine Echocardiography, Doppler - drug effects Exercise Test - drug effects Female Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Myocardial Contraction - drug effects Myocardial Contraction - physiology Myocardial Infarction - diagnostic imaging Myocardial Infarction - therapy Myocardial Ischemia - diagnostic imaging Myocardial Ischemia - therapy Reference Values stress Doppler stress echocardiography Systole - drug effects Systole - physiology systolic function Ultrasonic investigative techniques Ventricular Function, Left - drug effects Ventricular Function, Left - physiology |
| title | Dobutamine stress–Doppler echocardiography before and after coronary angioplasty |
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