Effects of oral administration of chlormadinone acetate on canine prostatic hypertrophy
Seven of the 25 dogs (4 to 15 years old) with benign prostatic hypertrophy (BPH) at the teaching hospital of Nippon Veterinary and Animal Science University from 1989 through 1990 were treated orally with chlormadinone acetate (CMA), a synthetic anti-androgen, 2 mg/kg/day, twice a day for 3 or 4 wee...
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| Veröffentlicht in: | Journal of Veterinary Medical Science 1993/08/15, Vol.55(4), pp.631-635 |
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| container_title | Journal of Veterinary Medical Science |
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| creator | Kawakami, E. (Nippon Veterinary and Zootechnical Coll., Musashino, Tokyo (Japan)) Tsutsui, T Shimizu, M Orima, H Makanae, Y Yajima, K Ogasa, A |
| description | Seven of the 25 dogs (4 to 15 years old) with benign prostatic hypertrophy (BPH) at the teaching hospital of Nippon Veterinary and Animal Science University from 1989 through 1990 were treated orally with chlormadinone acetate (CMA), a synthetic anti-androgen, 2 mg/kg/day, twice a day for 3 or 4 weeks. Prostatic size was measured by radiography and ultrasonography before and after CMA treatment, and prostatic volume was calculated from the images. Semen quality was examined in 3 of the dogs with BPH. Peripheral blood simples were collected and plasma levels of LH, 4-androstenedione, 5α-dihydrotestosterone, testosterone and estradiol-17β were measured. Clinical signs disappeared within 10 days after the start of CMA treatment. The mean (±S.E.) prostatic volume 3 or 4 weeks after treatment decreased to 39±4% of the pretreatment volume. The mean level of plasma testosterone in the dogs with BPH before treatment was significantly lower than that in the normal dogs (P |
| doi_str_mv | 10.1292/jvms.55.631 |
| format | Article |
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(Nippon Veterinary and Zootechnical Coll., Musashino, Tokyo (Japan)) ; Tsutsui, T ; Shimizu, M ; Orima, H ; Makanae, Y ; Yajima, K ; Ogasa, A</creator><creatorcontrib>Kawakami, E. (Nippon Veterinary and Zootechnical Coll., Musashino, Tokyo (Japan)) ; Tsutsui, T ; Shimizu, M ; Orima, H ; Makanae, Y ; Yajima, K ; Ogasa, A</creatorcontrib><description>Seven of the 25 dogs (4 to 15 years old) with benign prostatic hypertrophy (BPH) at the teaching hospital of Nippon Veterinary and Animal Science University from 1989 through 1990 were treated orally with chlormadinone acetate (CMA), a synthetic anti-androgen, 2 mg/kg/day, twice a day for 3 or 4 weeks. Prostatic size was measured by radiography and ultrasonography before and after CMA treatment, and prostatic volume was calculated from the images. Semen quality was examined in 3 of the dogs with BPH. Peripheral blood simples were collected and plasma levels of LH, 4-androstenedione, 5α-dihydrotestosterone, testosterone and estradiol-17β were measured. Clinical signs disappeared within 10 days after the start of CMA treatment. The mean (±S.E.) prostatic volume 3 or 4 weeks after treatment decreased to 39±4% of the pretreatment volume. The mean level of plasma testosterone in the dogs with BPH before treatment was significantly lower than that in the normal dogs (P<0.01). In 6 of the CMA-treated dogs the levels of all hormones examined, except LH, were significantly lower after CMA treatment than before (P<0.05). The sperm count and motility decreased and the percentage of abnormal sperms increased after CMA treatment. These results demonstrate that, although CMA treatment in dogs with BPH inhibits testicular function, the prostatic volume is markedly reduced and clinical signs disappear in a short period after the therapy. However, a relapse of BPH was observed approximately 6 months after oral CMA treatment in some dogs.</description><identifier>ISSN: 0916-7250</identifier><identifier>EISSN: 1347-7439</identifier><identifier>DOI: 10.1292/jvms.55.631</identifier><identifier>PMID: 7691191</identifier><language>eng</language><publisher>Japan: JAPANESE SOCIETY OF VETERINARY SCIENCE</publisher><subject>ADMINISTRACION ; ADMINISTRATION ; Administration, Oral ; Androstenedione - blood ; Animals ; BLOOD PLASMA ; canine ; CHIEN ; chlormadinone acetate ; Chlormadinone Acetate - administration & dosage ; Chlormadinone Acetate - pharmacology ; Chlormadinone Acetate - therapeutic use ; Dihydrotestosterone - blood ; Dog Diseases ; DOGS ; DRUGS ; Estradiol - blood ; HIPERTROFIA ; HYPERTROPHIE ; HYPERTROPHY ; Luteinizing Hormone - blood ; Male ; MEDICAMENT ; MEDICAMENTOS ; PERRO ; PLASMA SANGUIN ; PLASMA SANGUINEO ; PROSTATA ; PROSTATE ; Prostate - drug effects ; Prostate - pathology ; Prostatic Hyperplasia - blood ; Prostatic Hyperplasia - drug therapy ; Prostatic Hyperplasia - veterinary ; prostatic hypertrophy ; Reference Values ; TERAPIA ; TESTOSTERONAS ; TESTOSTERONE ; THERAPEUTIQUE ; THERAPY</subject><ispartof>Journal of Veterinary Medical Science, 1993/08/15, Vol.55(4), pp.631-635</ispartof><rights>The Japanese Society of Veterinary Science</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-601d54234f84eb928efaf3c068644b805db1f02a4f6564d6456fcca1737225033</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7691191$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kawakami, E. (Nippon Veterinary and Zootechnical Coll., Musashino, Tokyo (Japan))</creatorcontrib><creatorcontrib>Tsutsui, T</creatorcontrib><creatorcontrib>Shimizu, M</creatorcontrib><creatorcontrib>Orima, H</creatorcontrib><creatorcontrib>Makanae, Y</creatorcontrib><creatorcontrib>Yajima, K</creatorcontrib><creatorcontrib>Ogasa, A</creatorcontrib><title>Effects of oral administration of chlormadinone acetate on canine prostatic hypertrophy</title><title>Journal of Veterinary Medical Science</title><addtitle>J. Vet. Med. Sci.</addtitle><description>Seven of the 25 dogs (4 to 15 years old) with benign prostatic hypertrophy (BPH) at the teaching hospital of Nippon Veterinary and Animal Science University from 1989 through 1990 were treated orally with chlormadinone acetate (CMA), a synthetic anti-androgen, 2 mg/kg/day, twice a day for 3 or 4 weeks. Prostatic size was measured by radiography and ultrasonography before and after CMA treatment, and prostatic volume was calculated from the images. Semen quality was examined in 3 of the dogs with BPH. Peripheral blood simples were collected and plasma levels of LH, 4-androstenedione, 5α-dihydrotestosterone, testosterone and estradiol-17β were measured. Clinical signs disappeared within 10 days after the start of CMA treatment. The mean (±S.E.) prostatic volume 3 or 4 weeks after treatment decreased to 39±4% of the pretreatment volume. The mean level of plasma testosterone in the dogs with BPH before treatment was significantly lower than that in the normal dogs (P<0.01). In 6 of the CMA-treated dogs the levels of all hormones examined, except LH, were significantly lower after CMA treatment than before (P<0.05). The sperm count and motility decreased and the percentage of abnormal sperms increased after CMA treatment. These results demonstrate that, although CMA treatment in dogs with BPH inhibits testicular function, the prostatic volume is markedly reduced and clinical signs disappear in a short period after the therapy. However, a relapse of BPH was observed approximately 6 months after oral CMA treatment in some dogs.</description><subject>ADMINISTRACION</subject><subject>ADMINISTRATION</subject><subject>Administration, Oral</subject><subject>Androstenedione - blood</subject><subject>Animals</subject><subject>BLOOD PLASMA</subject><subject>canine</subject><subject>CHIEN</subject><subject>chlormadinone acetate</subject><subject>Chlormadinone Acetate - administration & dosage</subject><subject>Chlormadinone Acetate - pharmacology</subject><subject>Chlormadinone Acetate - therapeutic use</subject><subject>Dihydrotestosterone - blood</subject><subject>Dog Diseases</subject><subject>DOGS</subject><subject>DRUGS</subject><subject>Estradiol - blood</subject><subject>HIPERTROFIA</subject><subject>HYPERTROPHIE</subject><subject>HYPERTROPHY</subject><subject>Luteinizing Hormone - blood</subject><subject>Male</subject><subject>MEDICAMENT</subject><subject>MEDICAMENTOS</subject><subject>PERRO</subject><subject>PLASMA SANGUIN</subject><subject>PLASMA SANGUINEO</subject><subject>PROSTATA</subject><subject>PROSTATE</subject><subject>Prostate - drug effects</subject><subject>Prostate - pathology</subject><subject>Prostatic Hyperplasia - blood</subject><subject>Prostatic Hyperplasia - drug therapy</subject><subject>Prostatic Hyperplasia - veterinary</subject><subject>prostatic hypertrophy</subject><subject>Reference Values</subject><subject>TERAPIA</subject><subject>TESTOSTERONAS</subject><subject>TESTOSTERONE</subject><subject>THERAPEUTIQUE</subject><subject>THERAPY</subject><issn>0916-7250</issn><issn>1347-7439</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1r4zAQxUXZ0k3TnnpbWPBpL8Wpvm0dl36XQHvoskcxkaVGwbayklPIf79yHXKZgfceP2YeQlcELwhV9Gbz2aWFEAvJyAmaEcarsuJMfUMzrIgsKyrwd3Se0gZjSrhUZ-iskooQRWbo771z1gypCK4IEdoCms73Pg0RBh_6UTbrNsQOGt-H3hZg7ACDLbJnoPdZ2caQsuRNsd5vbRxi2K73F-jUQZvs5WHP0Z-H-_fbp3L5-vh8-3tZGo7JUEpMGsEp467mdqVobR04ZrCsJeerGotmRRymwJ0UkjeSC-mMAVKxiua3GJujXxM3X_FvZ9OgO5-MbVvobdglXQlVc0xVDl5PQZPPTdE6vY2-g7jXBOuxRj3WqIXQucac_nnA7ladbY7ZQ2_Zv5v8TX79wx59iLmH1n6xiFJk5PFpZOzRNmuI2vYZ82PCOAgaPqJP-uVNcSwlrdh_aA-PWg</recordid><startdate>19930801</startdate><enddate>19930801</enddate><creator>Kawakami, E. 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(Nippon Veterinary and Zootechnical Coll., Musashino, Tokyo (Japan)) ; Tsutsui, T ; Shimizu, M ; Orima, H ; Makanae, Y ; Yajima, K ; Ogasa, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-601d54234f84eb928efaf3c068644b805db1f02a4f6564d6456fcca1737225033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>ADMINISTRACION</topic><topic>ADMINISTRATION</topic><topic>Administration, Oral</topic><topic>Androstenedione - blood</topic><topic>Animals</topic><topic>BLOOD PLASMA</topic><topic>canine</topic><topic>CHIEN</topic><topic>chlormadinone acetate</topic><topic>Chlormadinone Acetate - administration & dosage</topic><topic>Chlormadinone Acetate - pharmacology</topic><topic>Chlormadinone Acetate - therapeutic use</topic><topic>Dihydrotestosterone - blood</topic><topic>Dog Diseases</topic><topic>DOGS</topic><topic>DRUGS</topic><topic>Estradiol - blood</topic><topic>HIPERTROFIA</topic><topic>HYPERTROPHIE</topic><topic>HYPERTROPHY</topic><topic>Luteinizing Hormone - blood</topic><topic>Male</topic><topic>MEDICAMENT</topic><topic>MEDICAMENTOS</topic><topic>PERRO</topic><topic>PLASMA SANGUIN</topic><topic>PLASMA SANGUINEO</topic><topic>PROSTATA</topic><topic>PROSTATE</topic><topic>Prostate - drug effects</topic><topic>Prostate - pathology</topic><topic>Prostatic Hyperplasia - blood</topic><topic>Prostatic Hyperplasia - drug therapy</topic><topic>Prostatic Hyperplasia - veterinary</topic><topic>prostatic hypertrophy</topic><topic>Reference Values</topic><topic>TERAPIA</topic><topic>TESTOSTERONAS</topic><topic>TESTOSTERONE</topic><topic>THERAPEUTIQUE</topic><topic>THERAPY</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawakami, E. (Nippon Veterinary and Zootechnical Coll., Musashino, Tokyo (Japan))</creatorcontrib><creatorcontrib>Tsutsui, T</creatorcontrib><creatorcontrib>Shimizu, M</creatorcontrib><creatorcontrib>Orima, H</creatorcontrib><creatorcontrib>Makanae, Y</creatorcontrib><creatorcontrib>Yajima, K</creatorcontrib><creatorcontrib>Ogasa, A</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Veterinary Medical Science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawakami, E. (Nippon Veterinary and Zootechnical Coll., Musashino, Tokyo (Japan))</au><au>Tsutsui, T</au><au>Shimizu, M</au><au>Orima, H</au><au>Makanae, Y</au><au>Yajima, K</au><au>Ogasa, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of oral administration of chlormadinone acetate on canine prostatic hypertrophy</atitle><jtitle>Journal of Veterinary Medical Science</jtitle><addtitle>J. Vet. Med. Sci.</addtitle><date>1993-08-01</date><risdate>1993</risdate><volume>55</volume><issue>4</issue><spage>631</spage><epage>635</epage><pages>631-635</pages><issn>0916-7250</issn><eissn>1347-7439</eissn><abstract>Seven of the 25 dogs (4 to 15 years old) with benign prostatic hypertrophy (BPH) at the teaching hospital of Nippon Veterinary and Animal Science University from 1989 through 1990 were treated orally with chlormadinone acetate (CMA), a synthetic anti-androgen, 2 mg/kg/day, twice a day for 3 or 4 weeks. Prostatic size was measured by radiography and ultrasonography before and after CMA treatment, and prostatic volume was calculated from the images. Semen quality was examined in 3 of the dogs with BPH. Peripheral blood simples were collected and plasma levels of LH, 4-androstenedione, 5α-dihydrotestosterone, testosterone and estradiol-17β were measured. Clinical signs disappeared within 10 days after the start of CMA treatment. The mean (±S.E.) prostatic volume 3 or 4 weeks after treatment decreased to 39±4% of the pretreatment volume. The mean level of plasma testosterone in the dogs with BPH before treatment was significantly lower than that in the normal dogs (P<0.01). In 6 of the CMA-treated dogs the levels of all hormones examined, except LH, were significantly lower after CMA treatment than before (P<0.05). The sperm count and motility decreased and the percentage of abnormal sperms increased after CMA treatment. These results demonstrate that, although CMA treatment in dogs with BPH inhibits testicular function, the prostatic volume is markedly reduced and clinical signs disappear in a short period after the therapy. However, a relapse of BPH was observed approximately 6 months after oral CMA treatment in some dogs.</abstract><cop>Japan</cop><pub>JAPANESE SOCIETY OF VETERINARY SCIENCE</pub><pmid>7691191</pmid><doi>10.1292/jvms.55.631</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | ADMINISTRACION ADMINISTRATION Administration, Oral Androstenedione - blood Animals BLOOD PLASMA canine CHIEN chlormadinone acetate Chlormadinone Acetate - administration & dosage Chlormadinone Acetate - pharmacology Chlormadinone Acetate - therapeutic use Dihydrotestosterone - blood Dog Diseases DOGS DRUGS Estradiol - blood HIPERTROFIA HYPERTROPHIE HYPERTROPHY Luteinizing Hormone - blood Male MEDICAMENT MEDICAMENTOS PERRO PLASMA SANGUIN PLASMA SANGUINEO PROSTATA PROSTATE Prostate - drug effects Prostate - pathology Prostatic Hyperplasia - blood Prostatic Hyperplasia - drug therapy Prostatic Hyperplasia - veterinary prostatic hypertrophy Reference Values TERAPIA TESTOSTERONAS TESTOSTERONE THERAPEUTIQUE THERAPY |
| title | Effects of oral administration of chlormadinone acetate on canine prostatic hypertrophy |
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