Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

bcl-2 —/— mice complete embryonic development, but display growth retardation and early mortality postnatally. Hematopoiesis including lymphocyte differentiation is initially normal, but thymus and spleen undergo massive apoptotic involution. Thymocytes require an apoptotic signal to manifest accele...

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Veröffentlicht in:	Cell 1993-10, Vol.75 (2), p.229-240
Hauptverfasser:	Veis, Deborah J., Sorenson, Christine M., Shutter, John R., Korsmeyer, Stanley J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - genetics Biological and medical sciences Dexamethasone - pharmacology Disease Models, Animal Fundamental and applied biological sciences. Psychology Gene expression Hair - pathology Hematopoiesis Hypopigmentation - genetics Lymphocytes - physiology Lymphoid Tissue - embryology Lymphoid Tissue - pathology Mice Mice, Mutant Strains Molecular and cellular biology Molecular genetics Phenotype Polycystic Kidney Diseases - genetics Proto-Oncogene Proteins - deficiency Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-bcl-2 Spleen - pathology Thymus Gland - drug effects Thymus Gland - pathology Thymus Gland - radiation effects
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