Laser-Fused Biologic Vascular Graft Anastomoses

Tissue fusion using laser energy is a promising new technology that may improve the healing of anastomoses. This study evaluated the feasibility of using argon laser energy to fuse vascular tissue and biologic vascular prostheses (St. Jude Medical, Inc.) in a canine arteriovenous (A-V) fistula model...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of investigative surgery 1993, Vol.6 (3), p.289-295
Hauptverfasser: Tabbara, Marwan, White, Rodney A., Kopchok, George, Mirsch, William, Cormier, Francois, Cavaye, Douglas
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 295
container_issue 3
container_start_page 289
container_title Journal of investigative surgery
container_volume 6
creator Tabbara, Marwan
White, Rodney A.
Kopchok, George
Mirsch, William
Cormier, Francois
Cavaye, Douglas
description Tissue fusion using laser energy is a promising new technology that may improve the healing of anastomoses. This study evaluated the feasibility of using argon laser energy to fuse vascular tissue and biologic vascular prostheses (St. Jude Medical, Inc.) in a canine arteriovenous (A-V) fistula model. Five animals had 4-cm length, 3-mm internal diameter grafts (n;eq 10) placed bilaterally as side-to-side A-V interpositions from the femoral artery to femoral vein. One A-V graft was placed using argon laser energy with the vessel edges aligned by 6-0 polypropylene traction sutures at 3 to 4 mm intervals. The contralateral graft was sutured using running 6-0 polypropylene suture. Anastomoses were successfully fashioned in all animals except for episodes of delayed bleeding at two laser-fused segments (15 min and 2 hrs) and one segment in a suture control (6 days). The implants were removed to evaluate the integrity and healing of the anastomoses at 2 hrs, 8 days, and at 7, 9, and 11 weeks. In all instances, there was no evidence of anastomotic dehissance or enlargement. Histologic examination of the anastomoses revealed coapted vessel and prosthetic edges in laser-fused specimens and a limited foreign-body response to the permanent sutures in the suture controls. In the longer term specimens there was marked intimal proliferation at the venous anastomosis in all implants, with recent bilateral occlusions of the 7 and 11 week implants at the venous connection. We conclude that laser fusion of biologic vascular prostheses to autogenous vessel is possible with healing and no evidence of anastomotic dehissance. The technique may provide a method to limit development of anastomotic stenosis by eliminating the foreign body reaction. In addition, the canine arteriovenous model used in these experiments develops aggressive intimal lesions at the venous anastomosis within weeks and may be used to evaluate the effect of anastomotic technique on the development of this lesion.
doi_str_mv 10.3109/08941939309141618
format Article
fullrecord <record><control><sourceid>proquest_infor</sourceid><recordid>TN_cdi_proquest_miscellaneous_75982151</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>75982151</sourcerecordid><originalsourceid>FETCH-LOGICAL-c268t-e093a0e6e12b3ab6d60437f22815e31f7c5c01e5ac8e6c46076e4d4a811ea1da3</originalsourceid><addsrcrecordid>eNp9kFFLwzAUhYMoc05_gA_Cnnyry22atkFf5nBTGPiivoa79NZ1tM1MWmT_3pYNQUSfwuWc8xE-xi6B3wjgasJTFYESSnAFEcSQHrEhyBACLqU4ZsM-D_rCKTvzfsM5DyMlBmyQCqW6a8gmS_TkgnnrKRvfF7a074UZv6E3bYluvHCYN-Npjb6xlfXkz9lJjqWni8M7Yq_zh5fZY7B8XjzNpsvAhHHaBMSVQE4xQbgSuIqzmEciycMwBUkC8sRIw4EkmpRiE8U8iSnKIkwBCCFDMWLXe-7W2Y-WfKOrwhsqS6zJtl4nUqUhSOiKsC8aZ713lOutKyp0Ow1c95L0L0nd5uoAb1cVZd-Lg5Uuv9vnRZ1bV-GndWWmG9yV1uUOa1P4Hv03_vbHfE1YNmuDjvTGtq7uvP3zuS_kV4XC</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>75982151</pqid></control><display><type>article</type><title>Laser-Fused Biologic Vascular Graft Anastomoses</title><source>MEDLINE</source><source>Access via Taylor &amp; Francis</source><creator>Tabbara, Marwan ; White, Rodney A. ; Kopchok, George ; Mirsch, William ; Cormier, Francois ; Cavaye, Douglas</creator><creatorcontrib>Tabbara, Marwan ; White, Rodney A. ; Kopchok, George ; Mirsch, William ; Cormier, Francois ; Cavaye, Douglas</creatorcontrib><description>Tissue fusion using laser energy is a promising new technology that may improve the healing of anastomoses. This study evaluated the feasibility of using argon laser energy to fuse vascular tissue and biologic vascular prostheses (St. Jude Medical, Inc.) in a canine arteriovenous (A-V) fistula model. Five animals had 4-cm length, 3-mm internal diameter grafts (n;eq 10) placed bilaterally as side-to-side A-V interpositions from the femoral artery to femoral vein. One A-V graft was placed using argon laser energy with the vessel edges aligned by 6-0 polypropylene traction sutures at 3 to 4 mm intervals. The contralateral graft was sutured using running 6-0 polypropylene suture. Anastomoses were successfully fashioned in all animals except for episodes of delayed bleeding at two laser-fused segments (15 min and 2 hrs) and one segment in a suture control (6 days). The implants were removed to evaluate the integrity and healing of the anastomoses at 2 hrs, 8 days, and at 7, 9, and 11 weeks. In all instances, there was no evidence of anastomotic dehissance or enlargement. Histologic examination of the anastomoses revealed coapted vessel and prosthetic edges in laser-fused specimens and a limited foreign-body response to the permanent sutures in the suture controls. In the longer term specimens there was marked intimal proliferation at the venous anastomosis in all implants, with recent bilateral occlusions of the 7 and 11 week implants at the venous connection. We conclude that laser fusion of biologic vascular prostheses to autogenous vessel is possible with healing and no evidence of anastomotic dehissance. The technique may provide a method to limit development of anastomotic stenosis by eliminating the foreign body reaction. In addition, the canine arteriovenous model used in these experiments develops aggressive intimal lesions at the venous anastomosis within weeks and may be used to evaluate the effect of anastomotic technique on the development of this lesion.</description><identifier>ISSN: 0894-1939</identifier><identifier>EISSN: 1521-0553</identifier><identifier>DOI: 10.3109/08941939309141618</identifier><identifier>PMID: 8399000</identifier><language>eng</language><publisher>United States: Informa UK Ltd</publisher><subject>Animals ; Arteriovenous Fistula - surgery ; Blood Vessel Prosthesis ; Dogs ; Keywords Biologic grafts ; laser anastomoses ; Laser Therapy ; laser tissue fusion ; Postoperative Complications ; Sutures</subject><ispartof>Journal of investigative surgery, 1993, Vol.6 (3), p.289-295</ispartof><rights>1993 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1993</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c268t-e093a0e6e12b3ab6d60437f22815e31f7c5c01e5ac8e6c46076e4d4a811ea1da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/08941939309141618$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/08941939309141618$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,60436,61221,61402</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8399000$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tabbara, Marwan</creatorcontrib><creatorcontrib>White, Rodney A.</creatorcontrib><creatorcontrib>Kopchok, George</creatorcontrib><creatorcontrib>Mirsch, William</creatorcontrib><creatorcontrib>Cormier, Francois</creatorcontrib><creatorcontrib>Cavaye, Douglas</creatorcontrib><title>Laser-Fused Biologic Vascular Graft Anastomoses</title><title>Journal of investigative surgery</title><addtitle>J Invest Surg</addtitle><description>Tissue fusion using laser energy is a promising new technology that may improve the healing of anastomoses. This study evaluated the feasibility of using argon laser energy to fuse vascular tissue and biologic vascular prostheses (St. Jude Medical, Inc.) in a canine arteriovenous (A-V) fistula model. Five animals had 4-cm length, 3-mm internal diameter grafts (n;eq 10) placed bilaterally as side-to-side A-V interpositions from the femoral artery to femoral vein. One A-V graft was placed using argon laser energy with the vessel edges aligned by 6-0 polypropylene traction sutures at 3 to 4 mm intervals. The contralateral graft was sutured using running 6-0 polypropylene suture. Anastomoses were successfully fashioned in all animals except for episodes of delayed bleeding at two laser-fused segments (15 min and 2 hrs) and one segment in a suture control (6 days). The implants were removed to evaluate the integrity and healing of the anastomoses at 2 hrs, 8 days, and at 7, 9, and 11 weeks. In all instances, there was no evidence of anastomotic dehissance or enlargement. Histologic examination of the anastomoses revealed coapted vessel and prosthetic edges in laser-fused specimens and a limited foreign-body response to the permanent sutures in the suture controls. In the longer term specimens there was marked intimal proliferation at the venous anastomosis in all implants, with recent bilateral occlusions of the 7 and 11 week implants at the venous connection. We conclude that laser fusion of biologic vascular prostheses to autogenous vessel is possible with healing and no evidence of anastomotic dehissance. The technique may provide a method to limit development of anastomotic stenosis by eliminating the foreign body reaction. In addition, the canine arteriovenous model used in these experiments develops aggressive intimal lesions at the venous anastomosis within weeks and may be used to evaluate the effect of anastomotic technique on the development of this lesion.</description><subject>Animals</subject><subject>Arteriovenous Fistula - surgery</subject><subject>Blood Vessel Prosthesis</subject><subject>Dogs</subject><subject>Keywords Biologic grafts</subject><subject>laser anastomoses</subject><subject>Laser Therapy</subject><subject>laser tissue fusion</subject><subject>Postoperative Complications</subject><subject>Sutures</subject><issn>0894-1939</issn><issn>1521-0553</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kFFLwzAUhYMoc05_gA_Cnnyry22atkFf5nBTGPiivoa79NZ1tM1MWmT_3pYNQUSfwuWc8xE-xi6B3wjgasJTFYESSnAFEcSQHrEhyBACLqU4ZsM-D_rCKTvzfsM5DyMlBmyQCqW6a8gmS_TkgnnrKRvfF7a074UZv6E3bYluvHCYN-Npjb6xlfXkz9lJjqWni8M7Yq_zh5fZY7B8XjzNpsvAhHHaBMSVQE4xQbgSuIqzmEciycMwBUkC8sRIw4EkmpRiE8U8iSnKIkwBCCFDMWLXe-7W2Y-WfKOrwhsqS6zJtl4nUqUhSOiKsC8aZ713lOutKyp0Ow1c95L0L0nd5uoAb1cVZd-Lg5Uuv9vnRZ1bV-GndWWmG9yV1uUOa1P4Hv03_vbHfE1YNmuDjvTGtq7uvP3zuS_kV4XC</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>Tabbara, Marwan</creator><creator>White, Rodney A.</creator><creator>Kopchok, George</creator><creator>Mirsch, William</creator><creator>Cormier, Francois</creator><creator>Cavaye, Douglas</creator><general>Informa UK Ltd</general><general>Taylor &amp; Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1993</creationdate><title>Laser-Fused Biologic Vascular Graft Anastomoses</title><author>Tabbara, Marwan ; White, Rodney A. ; Kopchok, George ; Mirsch, William ; Cormier, Francois ; Cavaye, Douglas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c268t-e093a0e6e12b3ab6d60437f22815e31f7c5c01e5ac8e6c46076e4d4a811ea1da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Arteriovenous Fistula - surgery</topic><topic>Blood Vessel Prosthesis</topic><topic>Dogs</topic><topic>Keywords Biologic grafts</topic><topic>laser anastomoses</topic><topic>Laser Therapy</topic><topic>laser tissue fusion</topic><topic>Postoperative Complications</topic><topic>Sutures</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tabbara, Marwan</creatorcontrib><creatorcontrib>White, Rodney A.</creatorcontrib><creatorcontrib>Kopchok, George</creatorcontrib><creatorcontrib>Mirsch, William</creatorcontrib><creatorcontrib>Cormier, Francois</creatorcontrib><creatorcontrib>Cavaye, Douglas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of investigative surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tabbara, Marwan</au><au>White, Rodney A.</au><au>Kopchok, George</au><au>Mirsch, William</au><au>Cormier, Francois</au><au>Cavaye, Douglas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Laser-Fused Biologic Vascular Graft Anastomoses</atitle><jtitle>Journal of investigative surgery</jtitle><addtitle>J Invest Surg</addtitle><date>1993</date><risdate>1993</risdate><volume>6</volume><issue>3</issue><spage>289</spage><epage>295</epage><pages>289-295</pages><issn>0894-1939</issn><eissn>1521-0553</eissn><abstract>Tissue fusion using laser energy is a promising new technology that may improve the healing of anastomoses. This study evaluated the feasibility of using argon laser energy to fuse vascular tissue and biologic vascular prostheses (St. Jude Medical, Inc.) in a canine arteriovenous (A-V) fistula model. Five animals had 4-cm length, 3-mm internal diameter grafts (n;eq 10) placed bilaterally as side-to-side A-V interpositions from the femoral artery to femoral vein. One A-V graft was placed using argon laser energy with the vessel edges aligned by 6-0 polypropylene traction sutures at 3 to 4 mm intervals. The contralateral graft was sutured using running 6-0 polypropylene suture. Anastomoses were successfully fashioned in all animals except for episodes of delayed bleeding at two laser-fused segments (15 min and 2 hrs) and one segment in a suture control (6 days). The implants were removed to evaluate the integrity and healing of the anastomoses at 2 hrs, 8 days, and at 7, 9, and 11 weeks. In all instances, there was no evidence of anastomotic dehissance or enlargement. Histologic examination of the anastomoses revealed coapted vessel and prosthetic edges in laser-fused specimens and a limited foreign-body response to the permanent sutures in the suture controls. In the longer term specimens there was marked intimal proliferation at the venous anastomosis in all implants, with recent bilateral occlusions of the 7 and 11 week implants at the venous connection. We conclude that laser fusion of biologic vascular prostheses to autogenous vessel is possible with healing and no evidence of anastomotic dehissance. The technique may provide a method to limit development of anastomotic stenosis by eliminating the foreign body reaction. In addition, the canine arteriovenous model used in these experiments develops aggressive intimal lesions at the venous anastomosis within weeks and may be used to evaluate the effect of anastomotic technique on the development of this lesion.</abstract><cop>United States</cop><pub>Informa UK Ltd</pub><pmid>8399000</pmid><doi>10.3109/08941939309141618</doi><tpages>7</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0894-1939
ispartof Journal of investigative surgery, 1993, Vol.6 (3), p.289-295
issn 0894-1939
1521-0553
language eng
recordid cdi_proquest_miscellaneous_75982151
source MEDLINE; Access via Taylor & Francis
subjects Animals
Arteriovenous Fistula - surgery
Blood Vessel Prosthesis
Dogs
Keywords Biologic grafts
laser anastomoses
Laser Therapy
laser tissue fusion
Postoperative Complications
Sutures
title Laser-Fused Biologic Vascular Graft Anastomoses
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T00%3A42%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_infor&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Laser-Fused%20Biologic%20Vascular%20Graft%20Anastomoses&rft.jtitle=Journal%20of%20investigative%20surgery&rft.au=Tabbara,%20Marwan&rft.date=1993&rft.volume=6&rft.issue=3&rft.spage=289&rft.epage=295&rft.pages=289-295&rft.issn=0894-1939&rft.eissn=1521-0553&rft_id=info:doi/10.3109/08941939309141618&rft_dat=%3Cproquest_infor%3E75982151%3C/proquest_infor%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=75982151&rft_id=info:pmid/8399000&rfr_iscdi=true