Preoperative radiation therapy with sensitizers in the management of carcinoma of the rectum
There is enough evidence to show that adjuvant radiation therapy contributes to the management of patients with carcinoma of the rectum. In an effort to improve resectability and possibly survival rates, the use of chemosensitizers, combined with moderate doses of radiation used presurgically, was i...
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| Veröffentlicht in: | Diseases of the colon & rectum 1985-01, Vol.28 (1), p.56-57 |
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| container_title | Diseases of the colon & rectum |
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| creator | SISCHY, B GRANEY, M. J HINSON, E. J QAZI, R |
| description | There is enough evidence to show that adjuvant radiation therapy contributes to the management of patients with carcinoma of the rectum. In an effort to improve resectability and possibly survival rates, the use of chemosensitizers, combined with moderate doses of radiation used presurgically, was introduced for carcinomas larger than 5 cm in diameter requiring abdominoperineal resection. Based on our experience and that of others, it is believed that the method of administration of 5FU and mitomycin-C is an important factor in obtaining an increased therapeutic ratio. Because of the locoregional pattern of spread of rectal cancer, this adjuvant approach would appear suitable. A series of approximately 60 patients is discussed and the surgical findings and five-year survival is reported. |
| doi_str_mv | 10.1007/BF02553909 |
| format | Article |
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A series of approximately 60 patients is discussed and the surgical findings and five-year survival is reported.</description><subject>Antineoplastic Combined Chemotherapy Protocols - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Combined Modality Therapy</subject><subject>Fluorouracil - administration & dosage</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Mitomycin</subject><subject>Mitomycins - administration & dosage</subject><subject>Rectal Neoplasms - drug therapy</subject><subject>Rectal Neoplasms - radiotherapy</subject><subject>Rectal Neoplasms - surgery</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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Based on our experience and that of others, it is believed that the method of administration of 5FU and mitomycin-C is an important factor in obtaining an increased therapeutic ratio. Because of the locoregional pattern of spread of rectal cancer, this adjuvant approach would appear suitable. A series of approximately 60 patients is discussed and the surgical findings and five-year survival is reported.</abstract><cop>Secaucus, NJ</cop><pub>Springer</pub><pmid>3918840</pmid><doi>10.1007/BF02553909</doi><tpages>2</tpages></addata></record> |
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| ispartof | Diseases of the colon & rectum, 1985-01, Vol.28 (1), p.56-57 |
| issn | 0012-3706 1530-0358 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete; Alma/SFX Local Collection |
| subjects | Antineoplastic Combined Chemotherapy Protocols - administration & dosage Biological and medical sciences Combined Modality Therapy Fluorouracil - administration & dosage Gastroenterology. Liver. Pancreas. Abdomen Humans Medical sciences Mitomycin Mitomycins - administration & dosage Rectal Neoplasms - drug therapy Rectal Neoplasms - radiotherapy Rectal Neoplasms - surgery Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| title | Preoperative radiation therapy with sensitizers in the management of carcinoma of the rectum |
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