Medial Septal Lesions Disrupt Spatial, but Not Nonspatial, Working Memory in Rats
In Experiment 1, rats with small medial septal lesions were less able than were control rats to remember the location of the arm of a Y maze they had been forced to enter on the preceding sample run. Moreover, as the retention interval between the sample and choice runs on this spatial delayed nonma...
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| Veröffentlicht in: | Behavioral neuroscience 1993-08, Vol.107 (4), p.565-574 |
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| creator | Kelsey, John E Vargas, Hannah |
| description | In Experiment 1, rats with small medial septal lesions were less able than were control rats to remember the location of the arm of a Y maze they had been forced to enter on the preceding sample run. Moreover, as the retention interval between the sample and choice runs on this spatial delayed nonmatching-to-sample (DNMTS) task was increased to 1 and 2 min, the magnitude of the deficit increased. In contrast, these same lesioned rats were not deficient in Experiment 2 in their ability to remember the object they had encountered in the straight alley on the sample run. In fact, when the retention interval was increased to 1 min on this nonspatial DNMTS task, the rats with medial septal lesions were more accurate than were the controls. This pattern of results did not appear to be due to task difficulty, recovery of function, or sequence of training. Rather, these results indicate that damage to the septohippocampal system disrupts spatial working memory more than it disrupts nonspatial working memory. |
| doi_str_mv | 10.1037/0735-7044.107.4.565 |
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Moreover, as the retention interval between the sample and choice runs on this spatial delayed nonmatching-to-sample (DNMTS) task was increased to 1 and 2 min, the magnitude of the deficit increased. In contrast, these same lesioned rats were not deficient in Experiment 2 in their ability to remember the object they had encountered in the straight alley on the sample run. In fact, when the retention interval was increased to 1 min on this nonspatial DNMTS task, the rats with medial septal lesions were more accurate than were the controls. This pattern of results did not appear to be due to task difficulty, recovery of function, or sequence of training. Rather, these results indicate that damage to the septohippocampal system disrupts spatial working memory more than it disrupts nonspatial working memory.</description><identifier>ISSN: 0735-7044</identifier><identifier>EISSN: 1939-0084</identifier><identifier>DOI: 10.1037/0735-7044.107.4.565</identifier><identifier>PMID: 8397861</identifier><identifier>CODEN: BENEDJ</identifier><language>eng</language><publisher>Washington, DC: American Psychological Association</publisher><subject>Anatomical correlates of behavior ; Animal ; Animal memory ; Animals ; Behavioral psychophysiology ; Biological and medical sciences ; Brain ; Brain Mapping ; Discrimination Learning - physiology ; Fundamental and applied biological sciences. Psychology ; Hippocampus - physiology ; Male ; Mental Recall - physiology ; Neural Pathways - physiology ; Orientation - physiology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Rats, Sprague-Dawley ; Retention (Psychology) - physiology ; Rodents ; Septal Nuclei ; Septal Nuclei - physiology ; Septum Pellucidum - physiology ; Short Term Memory ; Spatial Memory</subject><ispartof>Behavioral neuroscience, 1993-08, Vol.107 (4), p.565-574</ispartof><rights>1993 American Psychological Association</rights><rights>1994 INIST-CNRS</rights><rights>Copyright American Psychological Association Aug 1993</rights><rights>1993, American Psychological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a444t-b0a341b919d4e243d32b30cc24348771415843cda4735e17df5f3ad8a96f6feb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3767434$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8397861$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kelsey, John E</creatorcontrib><creatorcontrib>Vargas, Hannah</creatorcontrib><title>Medial Septal Lesions Disrupt Spatial, but Not Nonspatial, Working Memory in Rats</title><title>Behavioral neuroscience</title><addtitle>Behav Neurosci</addtitle><description>In Experiment 1, rats with small medial septal lesions were less able than were control rats to remember the location of the arm of a Y maze they had been forced to enter on the preceding sample run. Moreover, as the retention interval between the sample and choice runs on this spatial delayed nonmatching-to-sample (DNMTS) task was increased to 1 and 2 min, the magnitude of the deficit increased. In contrast, these same lesioned rats were not deficient in Experiment 2 in their ability to remember the object they had encountered in the straight alley on the sample run. In fact, when the retention interval was increased to 1 min on this nonspatial DNMTS task, the rats with medial septal lesions were more accurate than were the controls. This pattern of results did not appear to be due to task difficulty, recovery of function, or sequence of training. Rather, these results indicate that damage to the septohippocampal system disrupts spatial working memory more than it disrupts nonspatial working memory.</description><subject>Anatomical correlates of behavior</subject><subject>Animal</subject><subject>Animal memory</subject><subject>Animals</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain Mapping</subject><subject>Discrimination Learning - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hippocampus - physiology</subject><subject>Male</subject><subject>Mental Recall - physiology</subject><subject>Neural Pathways - physiology</subject><subject>Orientation - physiology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Retention (Psychology) - physiology</subject><subject>Rodents</subject><subject>Septal Nuclei</subject><subject>Septal Nuclei - physiology</subject><subject>Septum Pellucidum - physiology</subject><subject>Short Term Memory</subject><subject>Spatial Memory</subject><issn>0735-7044</issn><issn>1939-0084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1P3DAQhi1ERRfKL0CVIlQ4NVt7PYmdI6J8SUurllYcrYnjIEM2CZ7ksP8er3ZZVT3AwRqP55nXHr-MHQk-FVyqb1zJLFUcIKZqCtMsz3bYRBSySDnXsMsmW-Ij2yd65JwDh2yP7WlZKJ2LCft16yqPTXLn-iGGuSPftZR89xTGfkjuehxi-WtSjkPyo1utll7P7rvw5NuH5NYturBMfJv8xoE-sQ81NuQON_GA_b28-HN-nc5_Xt2cn81TBIAhLTlKEGUhigrcDGQlZ6Xk1sYtaKUEiEyDtBVCnMEJVdVZLbHSWOR1XrtSHrDTtW4fuufR0WAWnqxrGmxdN5JRWaGUjnLvgSLP-UwLFcHj_8DHbgxtHMLkAqTKpBZvQTMutY6v5hGSa8iGjii42vTBLzAsjeBm5Z1ZOWNWzsRUGTDRu9j1eSM9lgtXbXs2ZsX6l00dyWJTB2ytpy0mVa7i50XsZI1hj6anpcUweNs4MmXr_rnuBSTwqss</recordid><startdate>19930801</startdate><enddate>19930801</enddate><creator>Kelsey, John E</creator><creator>Vargas, Hannah</creator><general>American Psychological Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7RZ</scope><scope>PSYQQ</scope><scope>7X8</scope></search><sort><creationdate>19930801</creationdate><title>Medial Septal Lesions Disrupt Spatial, but Not Nonspatial, Working Memory in Rats</title><author>Kelsey, John E ; Vargas, Hannah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a444t-b0a341b919d4e243d32b30cc24348771415843cda4735e17df5f3ad8a96f6feb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Anatomical correlates of behavior</topic><topic>Animal</topic><topic>Animal memory</topic><topic>Animals</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain Mapping</topic><topic>Discrimination Learning - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hippocampus - physiology</topic><topic>Male</topic><topic>Mental Recall - physiology</topic><topic>Neural Pathways - physiology</topic><topic>Orientation - physiology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Retention (Psychology) - physiology</topic><topic>Rodents</topic><topic>Septal Nuclei</topic><topic>Septal Nuclei - physiology</topic><topic>Septum Pellucidum - physiology</topic><topic>Short Term Memory</topic><topic>Spatial Memory</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kelsey, John E</creatorcontrib><creatorcontrib>Vargas, Hannah</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>APA PsycArticles®</collection><collection>ProQuest One Psychology</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioral neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kelsey, John E</au><au>Vargas, Hannah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Medial Septal Lesions Disrupt Spatial, but Not Nonspatial, Working Memory in Rats</atitle><jtitle>Behavioral neuroscience</jtitle><addtitle>Behav Neurosci</addtitle><date>1993-08-01</date><risdate>1993</risdate><volume>107</volume><issue>4</issue><spage>565</spage><epage>574</epage><pages>565-574</pages><issn>0735-7044</issn><eissn>1939-0084</eissn><coden>BENEDJ</coden><abstract>In Experiment 1, rats with small medial septal lesions were less able than were control rats to remember the location of the arm of a Y maze they had been forced to enter on the preceding sample run. Moreover, as the retention interval between the sample and choice runs on this spatial delayed nonmatching-to-sample (DNMTS) task was increased to 1 and 2 min, the magnitude of the deficit increased. In contrast, these same lesioned rats were not deficient in Experiment 2 in their ability to remember the object they had encountered in the straight alley on the sample run. In fact, when the retention interval was increased to 1 min on this nonspatial DNMTS task, the rats with medial septal lesions were more accurate than were the controls. This pattern of results did not appear to be due to task difficulty, recovery of function, or sequence of training. Rather, these results indicate that damage to the septohippocampal system disrupts spatial working memory more than it disrupts nonspatial working memory.</abstract><cop>Washington, DC</cop><pub>American Psychological Association</pub><pmid>8397861</pmid><doi>10.1037/0735-7044.107.4.565</doi><tpages>10</tpages></addata></record> |
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| subjects | Anatomical correlates of behavior Animal Animal memory Animals Behavioral psychophysiology Biological and medical sciences Brain Brain Mapping Discrimination Learning - physiology Fundamental and applied biological sciences. Psychology Hippocampus - physiology Male Mental Recall - physiology Neural Pathways - physiology Orientation - physiology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Sprague-Dawley Retention (Psychology) - physiology Rodents Septal Nuclei Septal Nuclei - physiology Septum Pellucidum - physiology Short Term Memory Spatial Memory |
| title | Medial Septal Lesions Disrupt Spatial, but Not Nonspatial, Working Memory in Rats |
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