Effect of naloxone on menopausal flushes, skin temperature, and luteinizing hormone secretion
The effect of naloxone (1.4 mg/hr for 3 hours) on subjectively experienced menopausal flushes, skin temperature, and luteinizing hormone secretion was investigated in seven women in a double-blind, saline-controlled, crossover study. Naloxone had no effect on the number of subjective flushes, episod...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 1985-01, Vol.151 (2), p.277-280 |
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| container_end_page | 280 |
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| container_title | American journal of obstetrics and gynecology |
| container_volume | 151 |
| creator | Tulandi, Togas Kinch, Robert A. Guyda, Harvey Maiolo, Loraine Mazzella Lal, Samarthji |
| description | The effect of naloxone (1.4 mg/hr for 3 hours) on subjectively experienced menopausal flushes, skin temperature, and luteinizing hormone secretion was investigated in seven women in a double-blind, saline-controlled, crossover study. Naloxone had no effect on the number of subjective flushes, episodic skin temperature elevation, luteinizing hormone pulses, variability of luteinizing hormone secretion, or total luteinizing hormone secretion. This study suggests that a naloxone-sensitive opioid mechanism is not active in modulating luteinizing hormone secretion in the postmenopausal woman and that opioid receptor blockade is not effective in altering the frequency of menopausal flushes. |
| doi_str_mv | 10.1016/0002-9378(85)90026-2 |
| format | Article |
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Naloxone had no effect on the number of subjective flushes, episodic skin temperature elevation, luteinizing hormone pulses, variability of luteinizing hormone secretion, or total luteinizing hormone secretion. This study suggests that a naloxone-sensitive opioid mechanism is not active in modulating luteinizing hormone secretion in the postmenopausal woman and that opioid receptor blockade is not effective in altering the frequency of menopausal flushes.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/0002-9378(85)90026-2</identifier><identifier>PMID: 2982266</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>Philadelphia, PA: Elsevier Inc</publisher><subject>Biological and medical sciences ; Climacteric - drug effects ; Female ; Gynecology. Andrology. 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Obstetrics</subject><subject>Humans</subject><subject>Luteinizing Hormone - metabolism</subject><subject>Medical sciences</subject><subject>menopausal flushes</subject><subject>Middle Aged</subject><subject>Naloxone</subject><subject>Naloxone - pharmacology</subject><subject>Puberal and climacteric disorders (male and female)</subject><subject>Receptors, Opioid - physiology</subject><subject>Skin Temperature - drug effects</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1LHTEUhoO06PXjHyhkUYqCo0lm8rUpFFErCN24lZDJnNS0M8ltMlNqf31nvJe7dBUO73NewnMQOqXkihIqrgkhrNK1VOeKX-h5EBXbQytKtKyEEuoDWu2QA3RYys9lZJrto32mFWNCrNDzrffgRpw8jrZPf1MEnCIeIKa1nYrtse-n8gLlEpdfIeIRhjVkO04ZLrGNHe6nEUIM_0L8gV9SHpaCAi7DGFI8Rh-97QucbN8j9HR3-3TzrXr8fv9w8_WxcrUSY8Wlo432QsiGN23rOkJJWysiPXDPOqsUo1Jwpaywymre2jl1neBSs4Y29RH6vKld5_R7gjKaIRQHfW8jpKkYybWUtV7AZgO6nErJ4M06h8HmV0OJWaSaRZFZjBnFzZtUw-a1s23_1A7Q7Za2Fuf80za3xdneZxtdKDtMM8EZr2fsywaDWcWfANkUFyA66EKeb2C6FN7_x3-CNZMz</recordid><startdate>19850115</startdate><enddate>19850115</enddate><creator>Tulandi, Togas</creator><creator>Kinch, Robert A.</creator><creator>Guyda, Harvey</creator><creator>Maiolo, Loraine Mazzella</creator><creator>Lal, Samarthji</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19850115</creationdate><title>Effect of naloxone on menopausal flushes, skin temperature, and luteinizing hormone secretion</title><author>Tulandi, Togas ; Kinch, Robert A. ; Guyda, Harvey ; Maiolo, Loraine Mazzella ; Lal, Samarthji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-57c149f667454bbcd010b3807fe5f2da882176588a6a8a95bab38cd657924143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Biological and medical sciences</topic><topic>Climacteric - drug effects</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Luteinizing Hormone - metabolism</topic><topic>Medical sciences</topic><topic>menopausal flushes</topic><topic>Middle Aged</topic><topic>Naloxone</topic><topic>Naloxone - pharmacology</topic><topic>Puberal and climacteric disorders (male and female)</topic><topic>Receptors, Opioid - physiology</topic><topic>Skin Temperature - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tulandi, Togas</creatorcontrib><creatorcontrib>Kinch, Robert A.</creatorcontrib><creatorcontrib>Guyda, Harvey</creatorcontrib><creatorcontrib>Maiolo, Loraine Mazzella</creatorcontrib><creatorcontrib>Lal, Samarthji</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tulandi, Togas</au><au>Kinch, Robert A.</au><au>Guyda, Harvey</au><au>Maiolo, Loraine Mazzella</au><au>Lal, Samarthji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of naloxone on menopausal flushes, skin temperature, and luteinizing hormone secretion</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1985-01-15</date><risdate>1985</risdate><volume>151</volume><issue>2</issue><spage>277</spage><epage>280</epage><pages>277-280</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>The effect of naloxone (1.4 mg/hr for 3 hours) on subjectively experienced menopausal flushes, skin temperature, and luteinizing hormone secretion was investigated in seven women in a double-blind, saline-controlled, crossover study. 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| identifier | ISSN: 0002-9378 |
| ispartof | American journal of obstetrics and gynecology, 1985-01, Vol.151 (2), p.277-280 |
| issn | 0002-9378 1097-6868 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences Climacteric - drug effects Female Gynecology. Andrology. Obstetrics Humans Luteinizing Hormone - metabolism Medical sciences menopausal flushes Middle Aged Naloxone Naloxone - pharmacology Puberal and climacteric disorders (male and female) Receptors, Opioid - physiology Skin Temperature - drug effects |
| title | Effect of naloxone on menopausal flushes, skin temperature, and luteinizing hormone secretion |
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