Cytogenetic findings in 20 melanomas
We report cytogenetic studies performed on 20 patients with cutaneous malignant melanoma, characterized by clinical and histological parameters. Cytogenetic analyses were performed on peripheral blood lymphocytes, in order to exclude the presence of constitutional chromosomal aberrations, and on pri...
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| Veröffentlicht in: | Melanoma research 1993-06, Vol.3 (3), p.169-172 |
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| container_title | Melanoma research |
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| creator | Grammatico, P Catricalà, C Potenza, C Amantea, A Roccella, M Roccella, F Eibenschutz, L Del Porto, G |
| description | We report cytogenetic studies performed on 20 patients with cutaneous malignant melanoma, characterized by clinical and histological parameters. Cytogenetic analyses were performed on peripheral blood lymphocytes, in order to exclude the presence of constitutional chromosomal aberrations, and on primary cell cultures obtained from neoplastic skin lesions. A metastasis was also cultured in order to characterize chromosome markers. Specific markers found in more than one patient were t(1;14)(q21;q32) and aberrations of the 4q21,8q24 and 10q24q26 regions. The research aims to identify possible subtypes of melanomas related to specific chromosomal markers. It is hoped that this will contribute to understanding of the aetiology and evolution of the disease in order to obtain a more exact classification. We compare our results with the data reported in the literature and discuss the possible role of the cytogenetic analyses in human malignant melanoma. |
| doi_str_mv | 10.1097/00008390-199306000-00004 |
| format | Article |
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Cytogenetic analyses were performed on peripheral blood lymphocytes, in order to exclude the presence of constitutional chromosomal aberrations, and on primary cell cultures obtained from neoplastic skin lesions. A metastasis was also cultured in order to characterize chromosome markers. Specific markers found in more than one patient were t(1;14)(q21;q32) and aberrations of the 4q21,8q24 and 10q24q26 regions. The research aims to identify possible subtypes of melanomas related to specific chromosomal markers. It is hoped that this will contribute to understanding of the aetiology and evolution of the disease in order to obtain a more exact classification. 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Cytogenetic analyses were performed on peripheral blood lymphocytes, in order to exclude the presence of constitutional chromosomal aberrations, and on primary cell cultures obtained from neoplastic skin lesions. A metastasis was also cultured in order to characterize chromosome markers. Specific markers found in more than one patient were t(1;14)(q21;q32) and aberrations of the 4q21,8q24 and 10q24q26 regions. The research aims to identify possible subtypes of melanomas related to specific chromosomal markers. It is hoped that this will contribute to understanding of the aetiology and evolution of the disease in order to obtain a more exact classification. We compare our results with the data reported in the literature and discuss the possible role of the cytogenetic analyses in human malignant melanoma.</description><subject>Adult</subject><subject>Aged</subject><subject>Chromosome Aberrations</subject><subject>Female</subject><subject>Genetic Markers</subject><subject>Humans</subject><subject>Male</subject><subject>Melanoma - genetics</subject><subject>Melanoma - pathology</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Skin Neoplasms - genetics</subject><subject>Skin Neoplasms - pathology</subject><issn>0960-8931</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kLtOw0AQRbcAhRD4BCQXiM4w631OiSIISJFooF6t1-PIyI_gtYv8PQ4xmWY0V3PncRhLODxyQPMEU1iBkHJEAXqq0qMkL9gSUENqUfArdh3jNwA3QokFW1g5eZRcsvv1Yeh21NJQhaSs2qJqdzGp2iSDpKHat13j4w27LH0d6XbOK_b1-vK5fku3H5v39fM2DYLDkKIvwIickKwpEDnqEmzIlQ_Sa5JFUFkmJRpVKjI6IA_eiMwQ15BbpQqxYg-nufu--xkpDq6pYqB6OoO6MTqj0Ag9fbli9tQY-i7Gnkq376vG9wfHwR2huH8o7gzlT5KT9W7eMeYNFWfjTET8AuQ9XMM</recordid><startdate>19930601</startdate><enddate>19930601</enddate><creator>Grammatico, P</creator><creator>Catricalà, C</creator><creator>Potenza, C</creator><creator>Amantea, A</creator><creator>Roccella, M</creator><creator>Roccella, F</creator><creator>Eibenschutz, L</creator><creator>Del Porto, G</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930601</creationdate><title>Cytogenetic findings in 20 melanomas</title><author>Grammatico, P ; Catricalà, C ; Potenza, C ; Amantea, A ; Roccella, M ; Roccella, F ; Eibenschutz, L ; Del Porto, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c310t-9ad073be9e87d99196f08cb5ac4a6e4dc52244975f5e76c91ca7327e160b855d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Chromosome Aberrations</topic><topic>Female</topic><topic>Genetic Markers</topic><topic>Humans</topic><topic>Male</topic><topic>Melanoma - genetics</topic><topic>Melanoma - pathology</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Skin Neoplasms - genetics</topic><topic>Skin Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grammatico, P</creatorcontrib><creatorcontrib>Catricalà, C</creatorcontrib><creatorcontrib>Potenza, C</creatorcontrib><creatorcontrib>Amantea, A</creatorcontrib><creatorcontrib>Roccella, M</creatorcontrib><creatorcontrib>Roccella, F</creatorcontrib><creatorcontrib>Eibenschutz, L</creatorcontrib><creatorcontrib>Del Porto, G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Melanoma research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grammatico, P</au><au>Catricalà, C</au><au>Potenza, C</au><au>Amantea, A</au><au>Roccella, M</au><au>Roccella, F</au><au>Eibenschutz, L</au><au>Del Porto, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytogenetic findings in 20 melanomas</atitle><jtitle>Melanoma research</jtitle><addtitle>Melanoma Res</addtitle><date>1993-06-01</date><risdate>1993</risdate><volume>3</volume><issue>3</issue><spage>169</spage><epage>172</epage><pages>169-172</pages><issn>0960-8931</issn><abstract>We report cytogenetic studies performed on 20 patients with cutaneous malignant melanoma, characterized by clinical and histological parameters. 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| ispartof | Melanoma research, 1993-06, Vol.3 (3), p.169-172 |
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| subjects | Adult Aged Chromosome Aberrations Female Genetic Markers Humans Male Melanoma - genetics Melanoma - pathology Middle Aged Prognosis Skin Neoplasms - genetics Skin Neoplasms - pathology |
| title | Cytogenetic findings in 20 melanomas |
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