S-Ketoprofen inhibits tenotomy-induced bone loss and dynamics in weanling rats
The objects of this study were to determine whether S-Ketoprofen, a non-steroidal anti-inflammatory drug (NSAID), can prevent immobilization (tenotomy)-induced bone loss in weanling rats. Forty-five 4-week-old Sprague—Dawley female rats were either sham-operated or subjected to knee tenotomy and tre...
Gespeichert in:
| Veröffentlicht in: | Bone and mineral 1993-06, Vol.21 (3), p.203-218 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 218 |
|---|---|
| container_issue | 3 |
| container_start_page | 203 |
| container_title | Bone and mineral |
| container_volume | 21 |
| creator | Zeng, Q.Q. Jee, W.S.S. Ke, H.Z. Wechter, W.J. |
| description | The objects of this study were to determine whether
S-Ketoprofen, a non-steroidal anti-inflammatory drug (NSAID), can prevent immobilization (tenotomy)-induced bone loss in weanling rats. Forty-five 4-week-old Sprague—Dawley female rats were either sham-operated or subjected to knee tenotomy and treated simultaneously with 0, 0.02, 0.1, 0.5 or 2.5 mg of
S-ketoprofen/kg per day for 21 days. We then studied double-fluorescent labeled proximal tibial longitudinal sections and tibial shaft cross sections using static and dynamic histomorphometry. Less cancellous bone mass in proximal tibial metaphyses was found in tenotomized controls than in basal (36%) and sham-operated (54%) controls. This was due to the inhibition of age-related bone gain and induced bone loss due to increased bone resorption and decreased bone formation.
S-ketoprofen prevented both the inhibition of age-related bone gain and the stimulation of bone loss at the 2.5 mg/kg per day dose level, while it only prevented bone loss at the 0.5 mg/kg dose levels. In cancellous bone, dynamic histomorphometry showed that
S-ketoprofen prevented the tenotomy induced decrease in bone formation and increase in bone resorption. In the tibial shaft, tenotomy inhibited the enlargement of total tissue area by depressing periosteal bone formation, and thus inhibited age-related cortical bone gain.
S-ketoprofen treatment did not prevent this change at all dose levels, but reduced marrow cavity area to increase cortical bone area at the 0.1, 0.5 and 2.5 mg/kg per dose levels compared to tenotomy controls. However, the cortical bone area in the 0.1 and 0.5 mg dose-treated tenotomy rats was still lower than in the age-related controls.
S-ketoprofen also prevented the increase in endocortical eroded perimeter induced by tenotomy. In summary, tenotomy inhibited age-related bone gain and stimulated bone loss in cancellous bone sites, and only inhibited age-related bone gain in cortical bone sites.
S-ketoprofen treatment at the highest dose levels prevented the changes in cancellous bone, and reduced marrow area to increase cortical bone in the tibial shafts. |
| doi_str_mv | 10.1016/S0169-6009(08)80231-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_75970024</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0169600908802310</els_id><sourcerecordid>75970024</sourcerecordid><originalsourceid>FETCH-LOGICAL-c441t-e1dadd2b23cfe7c781510b7e601ae4bfdf6234a16ca35a515f717009dcdc44a43</originalsourceid><addsrcrecordid>eNqFkbtOxDAQRV2AeP8BSCkQgiIwdpzHVgghXgJBAdTWxJ6AUeKA7QXt3-NlV9vS2NLcM-M714wdcDjlwKuz53RM8gpgcgzNSQOi4Dmssa1VeZNth_ABIBopxQbbaGQqCthij8_5PcXx048ducy6d9vaGLJIbozjMMutM1NNJmtHR1k_hpChM5mZORysDqkh-yF0vXVvmccYdtl6h32gveW9w16vr14ub_OHp5u7y4uHXEvJY07coDGiFYXuqNZ1w0sObU0VcCTZdqarRCGRVxqLEktedjWvk2OjTRqAsthhR4u5yfjXlEJUgw2a-h4djdOg6nKSePE_yKuqFCXwBJYLUPu0padOfXo7oJ8pDmoesvoLWc3TVNCov5AVpL6D5QPTdiCz6lomnPTDpY5BY995dNqGFSYbWTdSJGx_gTkMqFz0ydpkvgMUUFRJPl_IlEL9tuRV0JZc-hnrSUdlRvuPz19I3qM5</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16652501</pqid></control><display><type>article</type><title>S-Ketoprofen inhibits tenotomy-induced bone loss and dynamics in weanling rats</title><source>MEDLINE</source><source>NASA Technical Reports Server</source><source>Alma/SFX Local Collection</source><creator>Zeng, Q.Q. ; Jee, W.S.S. ; Ke, H.Z. ; Wechter, W.J.</creator><creatorcontrib>Zeng, Q.Q. ; Jee, W.S.S. ; Ke, H.Z. ; Wechter, W.J.</creatorcontrib><description>The objects of this study were to determine whether
S-Ketoprofen, a non-steroidal anti-inflammatory drug (NSAID), can prevent immobilization (tenotomy)-induced bone loss in weanling rats. Forty-five 4-week-old Sprague—Dawley female rats were either sham-operated or subjected to knee tenotomy and treated simultaneously with 0, 0.02, 0.1, 0.5 or 2.5 mg of
S-ketoprofen/kg per day for 21 days. We then studied double-fluorescent labeled proximal tibial longitudinal sections and tibial shaft cross sections using static and dynamic histomorphometry. Less cancellous bone mass in proximal tibial metaphyses was found in tenotomized controls than in basal (36%) and sham-operated (54%) controls. This was due to the inhibition of age-related bone gain and induced bone loss due to increased bone resorption and decreased bone formation.
S-ketoprofen prevented both the inhibition of age-related bone gain and the stimulation of bone loss at the 2.5 mg/kg per day dose level, while it only prevented bone loss at the 0.5 mg/kg dose levels. In cancellous bone, dynamic histomorphometry showed that
S-ketoprofen prevented the tenotomy induced decrease in bone formation and increase in bone resorption. In the tibial shaft, tenotomy inhibited the enlargement of total tissue area by depressing periosteal bone formation, and thus inhibited age-related cortical bone gain.
S-ketoprofen treatment did not prevent this change at all dose levels, but reduced marrow cavity area to increase cortical bone area at the 0.1, 0.5 and 2.5 mg/kg per dose levels compared to tenotomy controls. However, the cortical bone area in the 0.1 and 0.5 mg dose-treated tenotomy rats was still lower than in the age-related controls.
S-ketoprofen also prevented the increase in endocortical eroded perimeter induced by tenotomy. In summary, tenotomy inhibited age-related bone gain and stimulated bone loss in cancellous bone sites, and only inhibited age-related bone gain in cortical bone sites.
S-ketoprofen treatment at the highest dose levels prevented the changes in cancellous bone, and reduced marrow area to increase cortical bone in the tibial shafts.</description><identifier>ISSN: 0169-6009</identifier><identifier>DOI: 10.1016/S0169-6009(08)80231-0</identifier><identifier>PMID: 8400920</identifier><identifier>CODEN: BOMIET</identifier><language>eng</language><publisher>Ames Research Center: Elsevier Inc</publisher><subject>Animals ; Animals, Suckling ; Biological and medical sciences ; Body Weight - drug effects ; Bone Density - drug effects ; Bone formation ; Bone mass ; Bone resorption ; Bone Resorption - prevention & control ; Bones, joints and connective tissue. Antiinflammatory agents ; Female ; Femur - drug effects ; Immobilization ; Immobilization - adverse effects ; Ketoprofen - pharmacology ; Ketoprofen - therapeutic use ; Life Sciences (General) ; Medical sciences ; Organ Size - drug effects ; Pharmacology. Drug treatments ; Prevention ; Rats ; Rats, Sprague-Dawley ; S-Ketoprofen ; Space life sciences ; Tibia - drug effects</subject><ispartof>Bone and mineral, 1993-06, Vol.21 (3), p.203-218</ispartof><rights>1993 Elsevier Scientific Publishers Ireland Ltd. All rights reserved</rights><rights>Copyright Determination: PUBLIC_USE_PERMITTED</rights><rights>1993 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-e1dadd2b23cfe7c781510b7e601ae4bfdf6234a16ca35a515f717009dcdc44a43</citedby><cites>FETCH-LOGICAL-c441t-e1dadd2b23cfe7c781510b7e601ae4bfdf6234a16ca35a515f717009dcdc44a43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4847842$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8400920$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zeng, Q.Q.</creatorcontrib><creatorcontrib>Jee, W.S.S.</creatorcontrib><creatorcontrib>Ke, H.Z.</creatorcontrib><creatorcontrib>Wechter, W.J.</creatorcontrib><title>S-Ketoprofen inhibits tenotomy-induced bone loss and dynamics in weanling rats</title><title>Bone and mineral</title><addtitle>Bone Miner</addtitle><description>The objects of this study were to determine whether
S-Ketoprofen, a non-steroidal anti-inflammatory drug (NSAID), can prevent immobilization (tenotomy)-induced bone loss in weanling rats. Forty-five 4-week-old Sprague—Dawley female rats were either sham-operated or subjected to knee tenotomy and treated simultaneously with 0, 0.02, 0.1, 0.5 or 2.5 mg of
S-ketoprofen/kg per day for 21 days. We then studied double-fluorescent labeled proximal tibial longitudinal sections and tibial shaft cross sections using static and dynamic histomorphometry. Less cancellous bone mass in proximal tibial metaphyses was found in tenotomized controls than in basal (36%) and sham-operated (54%) controls. This was due to the inhibition of age-related bone gain and induced bone loss due to increased bone resorption and decreased bone formation.
S-ketoprofen prevented both the inhibition of age-related bone gain and the stimulation of bone loss at the 2.5 mg/kg per day dose level, while it only prevented bone loss at the 0.5 mg/kg dose levels. In cancellous bone, dynamic histomorphometry showed that
S-ketoprofen prevented the tenotomy induced decrease in bone formation and increase in bone resorption. In the tibial shaft, tenotomy inhibited the enlargement of total tissue area by depressing periosteal bone formation, and thus inhibited age-related cortical bone gain.
S-ketoprofen treatment did not prevent this change at all dose levels, but reduced marrow cavity area to increase cortical bone area at the 0.1, 0.5 and 2.5 mg/kg per dose levels compared to tenotomy controls. However, the cortical bone area in the 0.1 and 0.5 mg dose-treated tenotomy rats was still lower than in the age-related controls.
S-ketoprofen also prevented the increase in endocortical eroded perimeter induced by tenotomy. In summary, tenotomy inhibited age-related bone gain and stimulated bone loss in cancellous bone sites, and only inhibited age-related bone gain in cortical bone sites.
S-ketoprofen treatment at the highest dose levels prevented the changes in cancellous bone, and reduced marrow area to increase cortical bone in the tibial shafts.</description><subject>Animals</subject><subject>Animals, Suckling</subject><subject>Biological and medical sciences</subject><subject>Body Weight - drug effects</subject><subject>Bone Density - drug effects</subject><subject>Bone formation</subject><subject>Bone mass</subject><subject>Bone resorption</subject><subject>Bone Resorption - prevention & control</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Female</subject><subject>Femur - drug effects</subject><subject>Immobilization</subject><subject>Immobilization - adverse effects</subject><subject>Ketoprofen - pharmacology</subject><subject>Ketoprofen - therapeutic use</subject><subject>Life Sciences (General)</subject><subject>Medical sciences</subject><subject>Organ Size - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Prevention</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>S-Ketoprofen</subject><subject>Space life sciences</subject><subject>Tibia - drug effects</subject><issn>0169-6009</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>CYI</sourceid><sourceid>EIF</sourceid><recordid>eNqFkbtOxDAQRV2AeP8BSCkQgiIwdpzHVgghXgJBAdTWxJ6AUeKA7QXt3-NlV9vS2NLcM-M714wdcDjlwKuz53RM8gpgcgzNSQOi4Dmssa1VeZNth_ABIBopxQbbaGQqCthij8_5PcXx048ducy6d9vaGLJIbozjMMutM1NNJmtHR1k_hpChM5mZORysDqkh-yF0vXVvmccYdtl6h32gveW9w16vr14ub_OHp5u7y4uHXEvJY07coDGiFYXuqNZ1w0sObU0VcCTZdqarRCGRVxqLEktedjWvk2OjTRqAsthhR4u5yfjXlEJUgw2a-h4djdOg6nKSePE_yKuqFCXwBJYLUPu0padOfXo7oJ8pDmoesvoLWc3TVNCov5AVpL6D5QPTdiCz6lomnPTDpY5BY995dNqGFSYbWTdSJGx_gTkMqFz0ydpkvgMUUFRJPl_IlEL9tuRV0JZc-hnrSUdlRvuPz19I3qM5</recordid><startdate>19930601</startdate><enddate>19930601</enddate><creator>Zeng, Q.Q.</creator><creator>Jee, W.S.S.</creator><creator>Ke, H.Z.</creator><creator>Wechter, W.J.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>CYE</scope><scope>CYI</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>19930601</creationdate><title>S-Ketoprofen inhibits tenotomy-induced bone loss and dynamics in weanling rats</title><author>Zeng, Q.Q. ; Jee, W.S.S. ; Ke, H.Z. ; Wechter, W.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-e1dadd2b23cfe7c781510b7e601ae4bfdf6234a16ca35a515f717009dcdc44a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Animals, Suckling</topic><topic>Biological and medical sciences</topic><topic>Body Weight - drug effects</topic><topic>Bone Density - drug effects</topic><topic>Bone formation</topic><topic>Bone mass</topic><topic>Bone resorption</topic><topic>Bone Resorption - prevention & control</topic><topic>Bones, joints and connective tissue. Antiinflammatory agents</topic><topic>Female</topic><topic>Femur - drug effects</topic><topic>Immobilization</topic><topic>Immobilization - adverse effects</topic><topic>Ketoprofen - pharmacology</topic><topic>Ketoprofen - therapeutic use</topic><topic>Life Sciences (General)</topic><topic>Medical sciences</topic><topic>Organ Size - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Prevention</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>S-Ketoprofen</topic><topic>Space life sciences</topic><topic>Tibia - drug effects</topic><toplevel>online_resources</toplevel><creatorcontrib>Zeng, Q.Q.</creatorcontrib><creatorcontrib>Jee, W.S.S.</creatorcontrib><creatorcontrib>Ke, H.Z.</creatorcontrib><creatorcontrib>Wechter, W.J.</creatorcontrib><collection>NASA Scientific and Technical Information</collection><collection>NASA Technical Reports Server</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Bone and mineral</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zeng, Q.Q.</au><au>Jee, W.S.S.</au><au>Ke, H.Z.</au><au>Wechter, W.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>S-Ketoprofen inhibits tenotomy-induced bone loss and dynamics in weanling rats</atitle><jtitle>Bone and mineral</jtitle><addtitle>Bone Miner</addtitle><date>1993-06-01</date><risdate>1993</risdate><volume>21</volume><issue>3</issue><spage>203</spage><epage>218</epage><pages>203-218</pages><issn>0169-6009</issn><coden>BOMIET</coden><abstract>The objects of this study were to determine whether
S-Ketoprofen, a non-steroidal anti-inflammatory drug (NSAID), can prevent immobilization (tenotomy)-induced bone loss in weanling rats. Forty-five 4-week-old Sprague—Dawley female rats were either sham-operated or subjected to knee tenotomy and treated simultaneously with 0, 0.02, 0.1, 0.5 or 2.5 mg of
S-ketoprofen/kg per day for 21 days. We then studied double-fluorescent labeled proximal tibial longitudinal sections and tibial shaft cross sections using static and dynamic histomorphometry. Less cancellous bone mass in proximal tibial metaphyses was found in tenotomized controls than in basal (36%) and sham-operated (54%) controls. This was due to the inhibition of age-related bone gain and induced bone loss due to increased bone resorption and decreased bone formation.
S-ketoprofen prevented both the inhibition of age-related bone gain and the stimulation of bone loss at the 2.5 mg/kg per day dose level, while it only prevented bone loss at the 0.5 mg/kg dose levels. In cancellous bone, dynamic histomorphometry showed that
S-ketoprofen prevented the tenotomy induced decrease in bone formation and increase in bone resorption. In the tibial shaft, tenotomy inhibited the enlargement of total tissue area by depressing periosteal bone formation, and thus inhibited age-related cortical bone gain.
S-ketoprofen treatment did not prevent this change at all dose levels, but reduced marrow cavity area to increase cortical bone area at the 0.1, 0.5 and 2.5 mg/kg per dose levels compared to tenotomy controls. However, the cortical bone area in the 0.1 and 0.5 mg dose-treated tenotomy rats was still lower than in the age-related controls.
S-ketoprofen also prevented the increase in endocortical eroded perimeter induced by tenotomy. In summary, tenotomy inhibited age-related bone gain and stimulated bone loss in cancellous bone sites, and only inhibited age-related bone gain in cortical bone sites.
S-ketoprofen treatment at the highest dose levels prevented the changes in cancellous bone, and reduced marrow area to increase cortical bone in the tibial shafts.</abstract><cop>Ames Research Center</cop><pub>Elsevier Inc</pub><pmid>8400920</pmid><doi>10.1016/S0169-6009(08)80231-0</doi><tpages>16</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0169-6009 |
| ispartof | Bone and mineral, 1993-06, Vol.21 (3), p.203-218 |
| issn | 0169-6009 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75970024 |
| source | MEDLINE; NASA Technical Reports Server; Alma/SFX Local Collection |
| subjects | Animals Animals, Suckling Biological and medical sciences Body Weight - drug effects Bone Density - drug effects Bone formation Bone mass Bone resorption Bone Resorption - prevention & control Bones, joints and connective tissue. Antiinflammatory agents Female Femur - drug effects Immobilization Immobilization - adverse effects Ketoprofen - pharmacology Ketoprofen - therapeutic use Life Sciences (General) Medical sciences Organ Size - drug effects Pharmacology. Drug treatments Prevention Rats Rats, Sprague-Dawley S-Ketoprofen Space life sciences Tibia - drug effects |
| title | S-Ketoprofen inhibits tenotomy-induced bone loss and dynamics in weanling rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-14T13%3A26%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=S-Ketoprofen%20inhibits%20tenotomy-induced%20bone%20loss%20and%20dynamics%20in%20weanling%20rats&rft.jtitle=Bone%20and%20mineral&rft.au=Zeng,%20Q.Q.&rft.date=1993-06-01&rft.volume=21&rft.issue=3&rft.spage=203&rft.epage=218&rft.pages=203-218&rft.issn=0169-6009&rft.coden=BOMIET&rft_id=info:doi/10.1016/S0169-6009(08)80231-0&rft_dat=%3Cproquest_cross%3E75970024%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16652501&rft_id=info:pmid/8400920&rft_els_id=S0169600908802310&rfr_iscdi=true |