Effect of indomethacin on cerebral oxidized cytochrome oxidase in preterm infants

To determine the effect of i.v. indomethacin on cerebral intracellular oxygenation, as judged by changes in the concentration of oxidized cytochrome oxidase, studies were performed using near-infrared spectroscopy on 15 infants of 23 to 29 wk gestation, aged 8 to 30 d, who required the drug for clos...

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Veröffentlicht in:	Pediatric research 1993-06, Vol.33 (6), p.603-608
Hauptverfasser:	MCCORMICK, D. C, EDWARDS, A. D, BROWN, G. C, WYATT, J. S, POTTER, A, COPE, M, DELPY, D. T, REYNOLDS, E. O. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain - drug effects Brain - enzymology Electron Transport Complex IV - chemistry Electron Transport Complex IV - metabolism Female General and cellular metabolism. Vitamins Humans In Vitro Techniques Indomethacin - administration & dosage Indomethacin - pharmacology Infant, Newborn Infant, Premature Injections, Intravenous Medical sciences Oxidation-Reduction Oxygen Consumption - drug effects Pharmacology. Drug treatments Rats Rats, Wistar Synaptosomes - drug effects Synaptosomes - metabolism
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