Simple relationships exist between dietary linoleate and the n−6 fatty acids of human neutrophils and plasma
Eicosanoids, the enzymatically oxygenated products of arachidonic acid (AA), appear to be overproduced in some disorders of inflammation. Dietary strategies for decreasing tissue AA require information on the relationships between dietary linoleic acid (LA) and tissue concentrations of AA. The use o...
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| Veröffentlicht in: | The American journal of clinical nutrition 1993-10, Vol.58 (4), p.497-500 |
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| creator | James, MJ Gibson, RA D'Angelo, M Neumann, MA Cleland, LG |
| description | Eicosanoids, the enzymatically oxygenated products of arachidonic acid (AA), appear to be overproduced in some disorders of inflammation. Dietary strategies for decreasing tissue AA require information on the relationships between dietary linoleic acid (LA) and tissue concentrations of AA. The use of either high- or low-LA spreads and cooking oils by healthy male volunteers resulted in a range of LA intakes of 2.5–17.5% of energy, as estimated by diet-diary analysis. Analysis of LA and AA concentrations in neutrophils and plasma lipid fractions from these subjects indicated that there were positive linear relationships between dietary LA and the LA concentrations in neutrophil phospholipids, plasma triglycerides, and plasma cholesteryl esters. By contrast, differences in dietary LA within a broad range were not associated with differences in concentrations of AA in these same neutrophil and plasma fractions. AA concentrations were decreased by supplementation of the diet with 4 g fish oil (1.6 g eicosapentaenoic acid, 0.3 g docosahexaenoic acid). The results suggest that the LA content of tissue lipids may be used to estimate LA intake, and the reduction of dietary LA by using standard dietary strategies is not likely to lead to reduction in tissue AA whereas this can be accomplished by fish-oil supplementation. |
| doi_str_mv | 10.1093/ajcn/58.4.497 |
| format | Article |
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Dietary strategies for decreasing tissue AA require information on the relationships between dietary linoleic acid (LA) and tissue concentrations of AA. The use of either high- or low-LA spreads and cooking oils by healthy male volunteers resulted in a range of LA intakes of 2.5–17.5% of energy, as estimated by diet-diary analysis. Analysis of LA and AA concentrations in neutrophils and plasma lipid fractions from these subjects indicated that there were positive linear relationships between dietary LA and the LA concentrations in neutrophil phospholipids, plasma triglycerides, and plasma cholesteryl esters. By contrast, differences in dietary LA within a broad range were not associated with differences in concentrations of AA in these same neutrophil and plasma fractions. AA concentrations were decreased by supplementation of the diet with 4 g fish oil (1.6 g eicosapentaenoic acid, 0.3 g docosahexaenoic acid). The results suggest that the LA content of tissue lipids may be used to estimate LA intake, and the reduction of dietary LA by using standard dietary strategies is not likely to lead to reduction in tissue AA whereas this can be accomplished by fish-oil supplementation.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/58.4.497</identifier><identifier>PMID: 8379505</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>ACEITES DE PESCADO ; ACIDE ARACHIDONIQUE ; ACIDE GRAS POLYINSATURE ; ACIDE LINOLEIQUE ; ACIDO ARAQUIDONICO ; ACIDO LINOLEICO ; ACIDOS GRASOS POLIINSATURADOS ; Adult ; Arachidonic Acid - blood ; Biological and medical sciences ; CHOLESTEROL ; COLESTEROL ; COMPLEMENT ALIMENTAIRE ; CORPS GRAS ; Diet ; Diet Records ; DIETA ; Dietary Fats - administration & dosage ; Dietary Fats - blood ; dietary fish oil ; Dietary linoleate ; Diseases of the osteoarticular system ; ESTER ; ESTERES ; EXPERIMENTACION ; EXPERIMENTATION ; Fatty Acids, Omega-6 ; Fatty Acids, Unsaturated - blood ; Fish Oils - administration & dosage ; GRANULOCITOS ; GRANULOCYTE ; GRASAS ; HOMBRES ; HOMME ; HUILE DE POISSON ; Humans ; Inflammatory joint diseases ; Linoleic Acid ; Linoleic Acids - administration & dosage ; Linoleic Acids - blood ; Lipids ; Male ; Medical sciences ; METABOLISME DES LIPIDES ; METABOLISMO DE LIPIDOS ; neutrophil fatty acids ; Neutrophils - chemistry ; plasma fatty acids ; PLASMA SANGUIN ; PLASMA SANGUINEO ; REGIME ALIMENTAIRE ; SUPLEMENTOS ; TRIGLICERIDOS ; TRIGLYCERIDE</subject><ispartof>The American journal of clinical nutrition, 1993-10, Vol.58 (4), p.497-500</ispartof><rights>1993 American Society for Nutrition.</rights><rights>1994 INIST-CNRS</rights><rights>Copyright American Society for Clinical Nutrition, Inc. 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Dietary strategies for decreasing tissue AA require information on the relationships between dietary linoleic acid (LA) and tissue concentrations of AA. The use of either high- or low-LA spreads and cooking oils by healthy male volunteers resulted in a range of LA intakes of 2.5–17.5% of energy, as estimated by diet-diary analysis. Analysis of LA and AA concentrations in neutrophils and plasma lipid fractions from these subjects indicated that there were positive linear relationships between dietary LA and the LA concentrations in neutrophil phospholipids, plasma triglycerides, and plasma cholesteryl esters. By contrast, differences in dietary LA within a broad range were not associated with differences in concentrations of AA in these same neutrophil and plasma fractions. AA concentrations were decreased by supplementation of the diet with 4 g fish oil (1.6 g eicosapentaenoic acid, 0.3 g docosahexaenoic acid). The results suggest that the LA content of tissue lipids may be used to estimate LA intake, and the reduction of dietary LA by using standard dietary strategies is not likely to lead to reduction in tissue AA whereas this can be accomplished by fish-oil supplementation.</description><subject>ACEITES DE PESCADO</subject><subject>ACIDE ARACHIDONIQUE</subject><subject>ACIDE GRAS POLYINSATURE</subject><subject>ACIDE LINOLEIQUE</subject><subject>ACIDO ARAQUIDONICO</subject><subject>ACIDO LINOLEICO</subject><subject>ACIDOS GRASOS POLIINSATURADOS</subject><subject>Adult</subject><subject>Arachidonic Acid - blood</subject><subject>Biological and medical sciences</subject><subject>CHOLESTEROL</subject><subject>COLESTEROL</subject><subject>COMPLEMENT ALIMENTAIRE</subject><subject>CORPS GRAS</subject><subject>Diet</subject><subject>Diet Records</subject><subject>DIETA</subject><subject>Dietary Fats - administration & dosage</subject><subject>Dietary Fats - blood</subject><subject>dietary fish oil</subject><subject>Dietary linoleate</subject><subject>Diseases of the osteoarticular system</subject><subject>ESTER</subject><subject>ESTERES</subject><subject>EXPERIMENTACION</subject><subject>EXPERIMENTATION</subject><subject>Fatty Acids, Omega-6</subject><subject>Fatty Acids, Unsaturated - blood</subject><subject>Fish Oils - administration & dosage</subject><subject>GRANULOCITOS</subject><subject>GRANULOCYTE</subject><subject>GRASAS</subject><subject>HOMBRES</subject><subject>HOMME</subject><subject>HUILE DE POISSON</subject><subject>Humans</subject><subject>Inflammatory joint diseases</subject><subject>Linoleic Acid</subject><subject>Linoleic Acids - administration & dosage</subject><subject>Linoleic Acids - blood</subject><subject>Lipids</subject><subject>Male</subject><subject>Medical sciences</subject><subject>METABOLISME DES LIPIDES</subject><subject>METABOLISMO DE LIPIDOS</subject><subject>neutrophil fatty acids</subject><subject>Neutrophils - chemistry</subject><subject>plasma fatty acids</subject><subject>PLASMA SANGUIN</subject><subject>PLASMA SANGUINEO</subject><subject>REGIME ALIMENTAIRE</subject><subject>SUPLEMENTOS</subject><subject>TRIGLICERIDOS</subject><subject>TRIGLYCERIDE</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc2KFDEUhYMoYzu6dCMIQcRd9SSVVCVZyuAfDLgYZx1SyS07TVVSJqnReQPXPqJPYtpuZiG4ulzOx7mXcxB6TsmWEsUuzN6Gi05u-ZYr8QBtqGKyYS0RD9GGENI2ivbdY_Qk5z0htOWyP0NnkgnVkW6DwrWflwlwgskUH0Pe-SVj-OFzwQOU7wABOw_FpDs8-RAnMAWwCQ6XHeDw--evHo-mlDtsrHcZxxHv1tkEHGAtKS47P-W_-DKZPJun6NFopgzPTvMc3bx_9-XyY3P1-cOny7dXjeUdKQ13oxjEwAdrQTAyWglCDpZDK41RzCnqFKiBS6LakUqgY90GKfreUS7bnp2jN0ffJcVvK-SiZ58tTJMJENesRad6xtUBfPUPuI9rCvU33bJDlEKQCjVHyKaYc4JRL8nPNRJNiT6UoA8l6E5qrmsJlX95Ml2HGdw9fUq96q9PusnWTGMywfp8jzGpGOMHmxdHbDRRm6-pIjfXinNVT1RRHEWoMd56SDpbD8GC8wls0S76_3z3B1ydrU8</recordid><startdate>19931001</startdate><enddate>19931001</enddate><creator>James, MJ</creator><creator>Gibson, RA</creator><creator>D'Angelo, M</creator><creator>Neumann, MA</creator><creator>Cleland, LG</creator><general>Elsevier Inc</general><general>American Society for Clinical Nutrition</general><general>American Society for Clinical Nutrition, Inc</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19931001</creationdate><title>Simple relationships exist between dietary linoleate and the n−6 fatty acids of human neutrophils and plasma</title><author>James, MJ ; Gibson, RA ; D'Angelo, M ; Neumann, MA ; Cleland, LG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-4df7b7b4bcce730fc8e78bc4e28aa93d91d9e9b48092f18e1fe9bb8766d148263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>ACEITES DE PESCADO</topic><topic>ACIDE ARACHIDONIQUE</topic><topic>ACIDE GRAS POLYINSATURE</topic><topic>ACIDE LINOLEIQUE</topic><topic>ACIDO ARAQUIDONICO</topic><topic>ACIDO LINOLEICO</topic><topic>ACIDOS GRASOS POLIINSATURADOS</topic><topic>Adult</topic><topic>Arachidonic Acid - blood</topic><topic>Biological and medical sciences</topic><topic>CHOLESTEROL</topic><topic>COLESTEROL</topic><topic>COMPLEMENT ALIMENTAIRE</topic><topic>CORPS GRAS</topic><topic>Diet</topic><topic>Diet Records</topic><topic>DIETA</topic><topic>Dietary Fats - administration & dosage</topic><topic>Dietary Fats - blood</topic><topic>dietary fish oil</topic><topic>Dietary linoleate</topic><topic>Diseases of the osteoarticular system</topic><topic>ESTER</topic><topic>ESTERES</topic><topic>EXPERIMENTACION</topic><topic>EXPERIMENTATION</topic><topic>Fatty Acids, Omega-6</topic><topic>Fatty Acids, Unsaturated - blood</topic><topic>Fish Oils - administration & dosage</topic><topic>GRANULOCITOS</topic><topic>GRANULOCYTE</topic><topic>GRASAS</topic><topic>HOMBRES</topic><topic>HOMME</topic><topic>HUILE DE POISSON</topic><topic>Humans</topic><topic>Inflammatory joint diseases</topic><topic>Linoleic Acid</topic><topic>Linoleic Acids - administration & dosage</topic><topic>Linoleic Acids - blood</topic><topic>Lipids</topic><topic>Male</topic><topic>Medical sciences</topic><topic>METABOLISME DES LIPIDES</topic><topic>METABOLISMO DE LIPIDOS</topic><topic>neutrophil fatty acids</topic><topic>Neutrophils - chemistry</topic><topic>plasma fatty acids</topic><topic>PLASMA SANGUIN</topic><topic>PLASMA SANGUINEO</topic><topic>REGIME ALIMENTAIRE</topic><topic>SUPLEMENTOS</topic><topic>TRIGLICERIDOS</topic><topic>TRIGLYCERIDE</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>James, MJ</creatorcontrib><creatorcontrib>Gibson, RA</creatorcontrib><creatorcontrib>D'Angelo, M</creatorcontrib><creatorcontrib>Neumann, MA</creatorcontrib><creatorcontrib>Cleland, LG</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>James, MJ</au><au>Gibson, RA</au><au>D'Angelo, M</au><au>Neumann, MA</au><au>Cleland, LG</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Simple relationships exist between dietary linoleate and the n−6 fatty acids of human neutrophils and plasma</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>1993-10-01</date><risdate>1993</risdate><volume>58</volume><issue>4</issue><spage>497</spage><epage>500</epage><pages>497-500</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract>Eicosanoids, the enzymatically oxygenated products of arachidonic acid (AA), appear to be overproduced in some disorders of inflammation. Dietary strategies for decreasing tissue AA require information on the relationships between dietary linoleic acid (LA) and tissue concentrations of AA. The use of either high- or low-LA spreads and cooking oils by healthy male volunteers resulted in a range of LA intakes of 2.5–17.5% of energy, as estimated by diet-diary analysis. Analysis of LA and AA concentrations in neutrophils and plasma lipid fractions from these subjects indicated that there were positive linear relationships between dietary LA and the LA concentrations in neutrophil phospholipids, plasma triglycerides, and plasma cholesteryl esters. By contrast, differences in dietary LA within a broad range were not associated with differences in concentrations of AA in these same neutrophil and plasma fractions. AA concentrations were decreased by supplementation of the diet with 4 g fish oil (1.6 g eicosapentaenoic acid, 0.3 g docosahexaenoic acid). The results suggest that the LA content of tissue lipids may be used to estimate LA intake, and the reduction of dietary LA by using standard dietary strategies is not likely to lead to reduction in tissue AA whereas this can be accomplished by fish-oil supplementation.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>8379505</pmid><doi>10.1093/ajcn/58.4.497</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9165 |
| ispartof | The American journal of clinical nutrition, 1993-10, Vol.58 (4), p.497-500 |
| issn | 0002-9165 1938-3207 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | ACEITES DE PESCADO ACIDE ARACHIDONIQUE ACIDE GRAS POLYINSATURE ACIDE LINOLEIQUE ACIDO ARAQUIDONICO ACIDO LINOLEICO ACIDOS GRASOS POLIINSATURADOS Adult Arachidonic Acid - blood Biological and medical sciences CHOLESTEROL COLESTEROL COMPLEMENT ALIMENTAIRE CORPS GRAS Diet Diet Records DIETA Dietary Fats - administration & dosage Dietary Fats - blood dietary fish oil Dietary linoleate Diseases of the osteoarticular system ESTER ESTERES EXPERIMENTACION EXPERIMENTATION Fatty Acids, Omega-6 Fatty Acids, Unsaturated - blood Fish Oils - administration & dosage GRANULOCITOS GRANULOCYTE GRASAS HOMBRES HOMME HUILE DE POISSON Humans Inflammatory joint diseases Linoleic Acid Linoleic Acids - administration & dosage Linoleic Acids - blood Lipids Male Medical sciences METABOLISME DES LIPIDES METABOLISMO DE LIPIDOS neutrophil fatty acids Neutrophils - chemistry plasma fatty acids PLASMA SANGUIN PLASMA SANGUINEO REGIME ALIMENTAIRE SUPLEMENTOS TRIGLICERIDOS TRIGLYCERIDE |
| title | Simple relationships exist between dietary linoleate and the n−6 fatty acids of human neutrophils and plasma |
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