Human malignant melanoma cells express high-affinity receptors for melatonin: antiproliferative effects of melatonin and 6-chloromelatonin

In order to explore the potential oncostatic properties of the pineal hormone, melatonin, we have investigated its binding characteristics and functional effects in a human malignant melanoma (M-6) cell line. Binding studies in M-6 membranes showed the coexistence of 2-[ 125I]iodomelatonin binding s...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of pharmacology 1993-07, Vol.246 (2), p.89-96
Hauptverfasser:	Ying, Shui-Wang, Niles, Lennard P., Crocker, Candice
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Iodomelatonin 6-Chloromelatonin Adenylyl Cyclase Inhibitors Antineoplastic agents Biological and medical sciences cAMP Cell Division - drug effects Cell Membrane - metabolism Chemotherapy Colforsin - pharmacology Cyclic AMP - metabolism Cytostatic activity DNA, Neoplasm - biosynthesis Humans Indoles - pharmacology Iodine Radioisotopes Kinetics Medical sciences Melanoma - metabolism Melatonin Melatonin - analogs & derivatives Melatonin - pharmacology Melatonin receptors, Melanoma cells (Human) Nucleotides - pharmacology Pharmacology. Drug treatments Receptors, Melatonin Receptors, Neurotransmitter - biosynthesis Receptors, Neurotransmitter - metabolism Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!