Longitudinal comparisons of IHC ac and dc receptor potentials recorded from the guinea pig cochlea
Recordings were made from inner hair cells (IHC) at three locations distributed in the apical half of the guinea pig cochlea. Longitudinal variations in ac and dc components of receptor potentials produced in response to single-tone inputs were studied to further understand the ways in which IHCs co...
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| Veröffentlicht in: | Hearing research 1993-06, Vol.68 (1), p.107-114 |
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| creator | Cheatham, M.A. Dallos, P. |
| description | Recordings were made from inner hair cells (IHC) at three locations distributed in the apical half of the guinea pig cochlea. Longitudinal variations in ac and dc components of receptor potentials produced in response to single-tone inputs were studied to further understand the ways in which IHCs communicate with their innervating afferent dendrites. While neural synchrony probably depends on the ac receptor potential, discharge rate may be controlled by the dc receptor potential generated by the IHC transducer plus an ac component derived from the phasic receptor potential. The latter reflects low-pass filtering inherent in the hair cell's basolateral membrane and calcium-dependent synaptic processes. By comparing the frequency dependence of ac and dc components in cells with different characteristic frequencies, it may be possible to learn how neural response areas are formed and why their shapes change along the cochlear spiral. |
| doi_str_mv | 10.1016/0378-5955(93)90069-D |
| format | Article |
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Longitudinal variations in ac and dc components of receptor potentials produced in response to single-tone inputs were studied to further understand the ways in which IHCs communicate with their innervating afferent dendrites. While neural synchrony probably depends on the ac receptor potential, discharge rate may be controlled by the dc receptor potential generated by the IHC transducer plus an ac component derived from the phasic receptor potential. The latter reflects low-pass filtering inherent in the hair cell's basolateral membrane and calcium-dependent synaptic processes. 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Longitudinal variations in ac and dc components of receptor potentials produced in response to single-tone inputs were studied to further understand the ways in which IHCs communicate with their innervating afferent dendrites. While neural synchrony probably depends on the ac receptor potential, discharge rate may be controlled by the dc receptor potential generated by the IHC transducer plus an ac component derived from the phasic receptor potential. The latter reflects low-pass filtering inherent in the hair cell's basolateral membrane and calcium-dependent synaptic processes. 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Psychology</subject><subject>Guinea Pigs</subject><subject>Hair cell</subject><subject>Hair Cells, Auditory, Inner - physiology</subject><subject>Microelectrodes</subject><subject>Receptor potential</subject><subject>Synaptic processes</subject><subject>Synchrony</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Vestibulocochlear Nerve - physiology</subject><issn>0378-5955</issn><issn>1878-5891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2LFDEQhoMo67j6DxRyENFDa9L5vizIrLoLA170HNJJZTbS3WmTbsF_b7czzFFPBVVPvRRPIfSSkveUUPmBMKUbYYR4a9g7Q4g0ze0jtKN6a2tDH6PdBXmKntX6gxAqGG-v0JVmSrZE71B3yOMxzUtIo-uxz8PkSqp5rDhHfH-3x85jNwYcPC7gYZpzwVOeYZyT6-vWyyVAwLHkAc8PgI9LGsHhKR3XNP_Qg3uOnsSVhRfneo2-f_70bX_XHL5-ud9_PDSeUzU3Osa20zSKYDpnjKccYtf5jlNBDaXKBy5pkCx6Jn2MApR3kZmglQLTKsau0ZtT7lTyzwXqbIdUPfS9GyEv1SphJNFG_hekUrVcULWC_AT6kmstEO1U0uDKb0uJ3X5gN8F2E2wNs39_YG_XtVfn_KUbIFyWztLX-evz3FXv-ljc6FO9YFxTKQhfsZsTBqu0XwmKrT7B6CGkVftsQ07_vuMP5Aujkg</recordid><startdate>19930601</startdate><enddate>19930601</enddate><creator>Cheatham, M.A.</creator><creator>Dallos, P.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>19930601</creationdate><title>Longitudinal comparisons of IHC ac and dc receptor potentials recorded from the guinea pig cochlea</title><author>Cheatham, M.A. ; Dallos, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-8ff2b81f5d9ba99c14efbbcb41519117cd461d63fc36cff5e7caf39d877e92733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Acoustic Stimulation</topic><topic>Action Potentials - physiology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cochlea</topic><topic>Cochlea - cytology</topic><topic>Cochlea - physiology</topic><topic>Dendrites - physiology</topic><topic>Discharge rate</topic><topic>Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Guinea Pigs</topic><topic>Hair cell</topic><topic>Hair Cells, Auditory, Inner - physiology</topic><topic>Microelectrodes</topic><topic>Receptor potential</topic><topic>Synaptic processes</topic><topic>Synchrony</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Vestibulocochlear Nerve - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheatham, M.A.</creatorcontrib><creatorcontrib>Dallos, P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Hearing research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheatham, M.A.</au><au>Dallos, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal comparisons of IHC ac and dc receptor potentials recorded from the guinea pig cochlea</atitle><jtitle>Hearing research</jtitle><addtitle>Hear Res</addtitle><date>1993-06-01</date><risdate>1993</risdate><volume>68</volume><issue>1</issue><spage>107</spage><epage>114</epage><pages>107-114</pages><issn>0378-5955</issn><eissn>1878-5891</eissn><coden>HERED3</coden><abstract>Recordings were made from inner hair cells (IHC) at three locations distributed in the apical half of the guinea pig cochlea. Longitudinal variations in ac and dc components of receptor potentials produced in response to single-tone inputs were studied to further understand the ways in which IHCs communicate with their innervating afferent dendrites. While neural synchrony probably depends on the ac receptor potential, discharge rate may be controlled by the dc receptor potential generated by the IHC transducer plus an ac component derived from the phasic receptor potential. The latter reflects low-pass filtering inherent in the hair cell's basolateral membrane and calcium-dependent synaptic processes. By comparing the frequency dependence of ac and dc components in cells with different characteristic frequencies, it may be possible to learn how neural response areas are formed and why their shapes change along the cochlear spiral.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>8376208</pmid><doi>10.1016/0378-5955(93)90069-D</doi><tpages>8</tpages></addata></record> |
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| ispartof | Hearing research, 1993-06, Vol.68 (1), p.107-114 |
| issn | 0378-5955 1878-5891 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Acoustic Stimulation Action Potentials - physiology Animals Biological and medical sciences Cochlea Cochlea - cytology Cochlea - physiology Dendrites - physiology Discharge rate Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation Fundamental and applied biological sciences. Psychology Guinea Pigs Hair cell Hair Cells, Auditory, Inner - physiology Microelectrodes Receptor potential Synaptic processes Synchrony Vertebrates: nervous system and sense organs Vestibulocochlear Nerve - physiology |
| title | Longitudinal comparisons of IHC ac and dc receptor potentials recorded from the guinea pig cochlea |
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