Gonadal steroids regulate the expression of glial fibrillary acidic protein in the adult male rat hippocampus
This study demonstrates that gonadal steroids (estradiol, testosterone, dihydrotestosterone) can regulate the expression of glial fibrillary acidic protein in the adult male rat brain. Previously, we showed that castration of adult male rats increased glial fibrillary acidic protein messenger RNA in...
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| Veröffentlicht in: | Neuroscience 1993-07, Vol.55 (2), p.435-443 |
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| creator | Day, J.R. Laping, N.J. Lampert-Etchells, M. Brown, S.A. O'Callaghan, J.P. McNeill, T.H. Finch, C.E. |
| description | This study demonstrates that gonadal steroids (estradiol, testosterone, dihydrotestosterone) can regulate the expression of glial fibrillary acidic protein in the adult male rat brain. Previously, we showed that castration of adult male rats increased glial fibrillary acidic protein messenger RNA in the hippocampus and that this increase was additive with the increase induced by deafferenting entorhinal cortex lesions [
Day
el al. (1990)
Molec. Endocr.
4, 1995–2002]. We extended these effects of castration and entorhinal cortex lesion to glial fibrillary acidic protein, using immunoassays. Furthermore, we found regional differences in responses to castration and sex steroid replacement. In the hippocampus, glial fibrillary acidic protein expression was enhanced by castration and inhibited by sex steriods. In contrast, hypothalamic glial fibrillary acidic protein expression was inhibited by castration. Similar regional differences were also shown for astrocyte glial fibrillary acidic protein distribution by immunocytochemistry.
The regional specificity of glial fibrillary acidic protein expression after castration and sex steroid replacement is pertinent to the role of astrocytes in synaptic plasticity in unlesioned adults as well as in responses to lesions where the steroid milieu has been shown to influence sprouting. |
| doi_str_mv | 10.1016/0306-4522(93)90512-E |
| format | Article |
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Day
el al. (1990)
Molec. Endocr.
4, 1995–2002]. We extended these effects of castration and entorhinal cortex lesion to glial fibrillary acidic protein, using immunoassays. Furthermore, we found regional differences in responses to castration and sex steroid replacement. In the hippocampus, glial fibrillary acidic protein expression was enhanced by castration and inhibited by sex steriods. In contrast, hypothalamic glial fibrillary acidic protein expression was inhibited by castration. Similar regional differences were also shown for astrocyte glial fibrillary acidic protein distribution by immunocytochemistry.
The regional specificity of glial fibrillary acidic protein expression after castration and sex steroid replacement is pertinent to the role of astrocytes in synaptic plasticity in unlesioned adults as well as in responses to lesions where the steroid milieu has been shown to influence sprouting.</description><identifier>ISSN: 0306-4522</identifier><identifier>EISSN: 1873-7544</identifier><identifier>DOI: 10.1016/0306-4522(93)90512-E</identifier><identifier>PMID: 8377935</identifier><identifier>CODEN: NRSCDN</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Antisense Elements (Genetics) ; Astrocytes - drug effects ; Astrocytes - metabolism ; Biochemistry and metabolism ; Biological and medical sciences ; Blotting, Northern ; Central nervous system ; Cerebral Cortex - drug effects ; Cerebral Cortex - metabolism ; Dihydrotestosterone - blood ; Dihydrotestosterone - pharmacology ; Drug Implants ; Estradiol - blood ; Estradiol - pharmacology ; Fundamental and applied biological sciences. Psychology ; Gene Expression - drug effects ; Glial Fibrillary Acidic Protein - analysis ; Glial Fibrillary Acidic Protein - biosynthesis ; Hippocampus - drug effects ; Hippocampus - metabolism ; Hippocampus - physiology ; Hypothalamus - drug effects ; Hypothalamus - metabolism ; Immunohistochemistry ; Male ; Orchiectomy ; Rats ; Rats, Inbred F344 ; RNA Probes ; RNA, Messenger - analysis ; RNA, Messenger - biosynthesis ; Testosterone - blood ; Testosterone - pharmacology ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience, 1993-07, Vol.55 (2), p.435-443</ispartof><rights>1993 IBRO</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-d6b0169cc3656ea436bde3aec42b645e2fbce260fa8ed05428894c469894b1303</citedby><cites>FETCH-LOGICAL-c386t-d6b0169cc3656ea436bde3aec42b645e2fbce260fa8ed05428894c469894b1303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0306-4522(93)90512-E$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4835634$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8377935$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Day, J.R.</creatorcontrib><creatorcontrib>Laping, N.J.</creatorcontrib><creatorcontrib>Lampert-Etchells, M.</creatorcontrib><creatorcontrib>Brown, S.A.</creatorcontrib><creatorcontrib>O'Callaghan, J.P.</creatorcontrib><creatorcontrib>McNeill, T.H.</creatorcontrib><creatorcontrib>Finch, C.E.</creatorcontrib><title>Gonadal steroids regulate the expression of glial fibrillary acidic protein in the adult male rat hippocampus</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>This study demonstrates that gonadal steroids (estradiol, testosterone, dihydrotestosterone) can regulate the expression of glial fibrillary acidic protein in the adult male rat brain. Previously, we showed that castration of adult male rats increased glial fibrillary acidic protein messenger RNA in the hippocampus and that this increase was additive with the increase induced by deafferenting entorhinal cortex lesions [
Day
el al. (1990)
Molec. Endocr.
4, 1995–2002]. We extended these effects of castration and entorhinal cortex lesion to glial fibrillary acidic protein, using immunoassays. Furthermore, we found regional differences in responses to castration and sex steroid replacement. In the hippocampus, glial fibrillary acidic protein expression was enhanced by castration and inhibited by sex steriods. In contrast, hypothalamic glial fibrillary acidic protein expression was inhibited by castration. Similar regional differences were also shown for astrocyte glial fibrillary acidic protein distribution by immunocytochemistry.
The regional specificity of glial fibrillary acidic protein expression after castration and sex steroid replacement is pertinent to the role of astrocytes in synaptic plasticity in unlesioned adults as well as in responses to lesions where the steroid milieu has been shown to influence sprouting.</description><subject>Animals</subject><subject>Antisense Elements (Genetics)</subject><subject>Astrocytes - drug effects</subject><subject>Astrocytes - metabolism</subject><subject>Biochemistry and metabolism</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>Central nervous system</subject><subject>Cerebral Cortex - drug effects</subject><subject>Cerebral Cortex - metabolism</subject><subject>Dihydrotestosterone - blood</subject><subject>Dihydrotestosterone - pharmacology</subject><subject>Drug Implants</subject><subject>Estradiol - blood</subject><subject>Estradiol - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression - drug effects</subject><subject>Glial Fibrillary Acidic Protein - analysis</subject><subject>Glial Fibrillary Acidic Protein - biosynthesis</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>Hippocampus - physiology</subject><subject>Hypothalamus - drug effects</subject><subject>Hypothalamus - metabolism</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Orchiectomy</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>RNA Probes</subject><subject>RNA, Messenger - analysis</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Testosterone - blood</subject><subject>Testosterone - pharmacology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9r3DAQxUVoSDfbfoMUdCglPTiRrT-2L4GybNNAIJfkLGRpnKjIlivJpfn2kbNmjxWCOcxvZt57CF2U5KokpbgmlIiC8aq6bOn3lvCyKvYnaFM2NS1qztgHtDkiH9F5jL9JfpzRM3TW0LpuKd-g4daPyiiHY4LgrYk4wPPsVAKcXgDDvylAjNaP2Pf42dlM9rYL1jkVXrHS1liNp-AT2BHnvwwpM7uEB-UAB5Xwi50mr9UwzfETOu2Vi_B5rVv09HP_uPtV3D_c3u1-3BeaNiIVRnTZYKs1FVyAYlR0BqgCzapOMA5V32moBOlVAyY7qpqmZZqJNpeupIRu0bfD3qzszwwxycFGDVn0CH6OsuatIIKxDLIDqIOPMUAvp2CHbE2WRC4pyyVCuUQoWyrfU5b7PPZl3T93A5jj0Bpr7n9d-ypq5fqgRm3jEWMN5YIu128OGOQs_loIMmoLowZjA-gkjbf_1_EGzIqaBA</recordid><startdate>19930701</startdate><enddate>19930701</enddate><creator>Day, J.R.</creator><creator>Laping, N.J.</creator><creator>Lampert-Etchells, M.</creator><creator>Brown, S.A.</creator><creator>O'Callaghan, J.P.</creator><creator>McNeill, T.H.</creator><creator>Finch, C.E.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930701</creationdate><title>Gonadal steroids regulate the expression of glial fibrillary acidic protein in the adult male rat hippocampus</title><author>Day, J.R. ; Laping, N.J. ; Lampert-Etchells, M. ; Brown, S.A. ; O'Callaghan, J.P. ; McNeill, T.H. ; Finch, C.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-d6b0169cc3656ea436bde3aec42b645e2fbce260fa8ed05428894c469894b1303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Antisense Elements (Genetics)</topic><topic>Astrocytes - drug effects</topic><topic>Astrocytes - metabolism</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>Blotting, Northern</topic><topic>Central nervous system</topic><topic>Cerebral Cortex - drug effects</topic><topic>Cerebral Cortex - metabolism</topic><topic>Dihydrotestosterone - blood</topic><topic>Dihydrotestosterone - pharmacology</topic><topic>Drug Implants</topic><topic>Estradiol - blood</topic><topic>Estradiol - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression - drug effects</topic><topic>Glial Fibrillary Acidic Protein - analysis</topic><topic>Glial Fibrillary Acidic Protein - biosynthesis</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - metabolism</topic><topic>Hippocampus - physiology</topic><topic>Hypothalamus - drug effects</topic><topic>Hypothalamus - metabolism</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Orchiectomy</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>RNA Probes</topic><topic>RNA, Messenger - analysis</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Testosterone - blood</topic><topic>Testosterone - pharmacology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Day, J.R.</creatorcontrib><creatorcontrib>Laping, N.J.</creatorcontrib><creatorcontrib>Lampert-Etchells, M.</creatorcontrib><creatorcontrib>Brown, S.A.</creatorcontrib><creatorcontrib>O'Callaghan, J.P.</creatorcontrib><creatorcontrib>McNeill, T.H.</creatorcontrib><creatorcontrib>Finch, C.E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Day, J.R.</au><au>Laping, N.J.</au><au>Lampert-Etchells, M.</au><au>Brown, S.A.</au><au>O'Callaghan, J.P.</au><au>McNeill, T.H.</au><au>Finch, C.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gonadal steroids regulate the expression of glial fibrillary acidic protein in the adult male rat hippocampus</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>1993-07-01</date><risdate>1993</risdate><volume>55</volume><issue>2</issue><spage>435</spage><epage>443</epage><pages>435-443</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><abstract>This study demonstrates that gonadal steroids (estradiol, testosterone, dihydrotestosterone) can regulate the expression of glial fibrillary acidic protein in the adult male rat brain. Previously, we showed that castration of adult male rats increased glial fibrillary acidic protein messenger RNA in the hippocampus and that this increase was additive with the increase induced by deafferenting entorhinal cortex lesions [
Day
el al. (1990)
Molec. Endocr.
4, 1995–2002]. We extended these effects of castration and entorhinal cortex lesion to glial fibrillary acidic protein, using immunoassays. Furthermore, we found regional differences in responses to castration and sex steroid replacement. In the hippocampus, glial fibrillary acidic protein expression was enhanced by castration and inhibited by sex steriods. In contrast, hypothalamic glial fibrillary acidic protein expression was inhibited by castration. Similar regional differences were also shown for astrocyte glial fibrillary acidic protein distribution by immunocytochemistry.
The regional specificity of glial fibrillary acidic protein expression after castration and sex steroid replacement is pertinent to the role of astrocytes in synaptic plasticity in unlesioned adults as well as in responses to lesions where the steroid milieu has been shown to influence sprouting.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>8377935</pmid><doi>10.1016/0306-4522(93)90512-E</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Antisense Elements (Genetics) Astrocytes - drug effects Astrocytes - metabolism Biochemistry and metabolism Biological and medical sciences Blotting, Northern Central nervous system Cerebral Cortex - drug effects Cerebral Cortex - metabolism Dihydrotestosterone - blood Dihydrotestosterone - pharmacology Drug Implants Estradiol - blood Estradiol - pharmacology Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Glial Fibrillary Acidic Protein - analysis Glial Fibrillary Acidic Protein - biosynthesis Hippocampus - drug effects Hippocampus - metabolism Hippocampus - physiology Hypothalamus - drug effects Hypothalamus - metabolism Immunohistochemistry Male Orchiectomy Rats Rats, Inbred F344 RNA Probes RNA, Messenger - analysis RNA, Messenger - biosynthesis Testosterone - blood Testosterone - pharmacology Vertebrates: nervous system and sense organs |
| title | Gonadal steroids regulate the expression of glial fibrillary acidic protein in the adult male rat hippocampus |
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