Lipopolysaccharide Stimulation of Plasmacytoma Cells
Various preparations of lipopolysaccharides (LPS) were tested for their effect on 6 plasma tumor cell lines. LPS from Escherichia coli B5:055, Salmonella minnesota 1114, and R7 mutant, as well as the glycolipid from S. minnesota 595 were highly stimulatory on cell suspensions from solid transplantab...
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| Veröffentlicht in: | JNCI : Journal of the National Cancer Institute 1985-01, Vol.74 (1), p.197-201 |
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| creator | Platica, Micsunica Hollander, Vincent P. |
| description | Various preparations of lipopolysaccharides (LPS) were tested for their effect on 6 plasma tumor cell lines. LPS from Escherichia coli B5:055, Salmonella minnesota 1114, and R7 mutant, as well as the glycolipid from S. minnesota 595 were highly stimulatory on cell suspensions from solid transplantable plasma tumor cells MOPC 315 and MPC11, as measured by thymidine incorporation and cell proliferation. Even nanogram doses were effective. LPS preparations from S. minnesota R5 and endotoxin-free cell wall residues of R5 and R7 mutants of S. minnesota had no stimulatory effect on these cells. In contrast, 4 lines of tissue culture-adapted plasma tumor cells (Adj PC5, HOPC-1, MOPC-21, and MPC11 TC) were not affected by any LPS preparation tested. Lymphosarcoma P1798 cells were also unaffected by these LPS. |
| doi_str_mv | 10.1093/jnci/74.1.197 |
| format | Article |
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LPS from Escherichia coli B5:055, Salmonella minnesota 1114, and R7 mutant, as well as the glycolipid from S. minnesota 595 were highly stimulatory on cell suspensions from solid transplantable plasma tumor cells MOPC 315 and MPC11, as measured by thymidine incorporation and cell proliferation. Even nanogram doses were effective. LPS preparations from S. minnesota R5 and endotoxin-free cell wall residues of R5 and R7 mutants of S. minnesota had no stimulatory effect on these cells. In contrast, 4 lines of tissue culture-adapted plasma tumor cells (Adj PC5, HOPC-1, MOPC-21, and MPC11 TC) were not affected by any LPS preparation tested. Lymphosarcoma P1798 cells were also unaffected by these LPS.</description><identifier>ISSN: 0027-8874</identifier><identifier>EISSN: 1460-2105</identifier><identifier>DOI: 10.1093/jnci/74.1.197</identifier><identifier>PMID: 3855479</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Animals ; Biological and medical sciences ; Carcinogenesis, carcinogens and anticarcinogens ; Cell Division ; Cells, Cultured ; Culture Techniques ; Dose-Response Relationship, Drug ; General aspects ; Lipopolysaccharides - pharmacology ; Lymphoma, Non-Hodgkin - pathology ; Medical sciences ; Mice ; Plasmacytoma - pathology ; Thymidine - metabolism ; Tumors</subject><ispartof>JNCI : Journal of the National Cancer Institute, 1985-01, Vol.74 (1), p.197-201</ispartof><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9071995$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3855479$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Platica, Micsunica</creatorcontrib><creatorcontrib>Hollander, Vincent P.</creatorcontrib><title>Lipopolysaccharide Stimulation of Plasmacytoma Cells</title><title>JNCI : Journal of the National Cancer Institute</title><addtitle>Journal of the National Cancer Institute</addtitle><description>Various preparations of lipopolysaccharides (LPS) were tested for their effect on 6 plasma tumor cell lines. LPS from Escherichia coli B5:055, Salmonella minnesota 1114, and R7 mutant, as well as the glycolipid from S. minnesota 595 were highly stimulatory on cell suspensions from solid transplantable plasma tumor cells MOPC 315 and MPC11, as measured by thymidine incorporation and cell proliferation. Even nanogram doses were effective. LPS preparations from S. minnesota R5 and endotoxin-free cell wall residues of R5 and R7 mutants of S. minnesota had no stimulatory effect on these cells. In contrast, 4 lines of tissue culture-adapted plasma tumor cells (Adj PC5, HOPC-1, MOPC-21, and MPC11 TC) were not affected by any LPS preparation tested. Lymphosarcoma P1798 cells were also unaffected by these LPS.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Cell Division</subject><subject>Cells, Cultured</subject><subject>Culture Techniques</subject><subject>Dose-Response Relationship, Drug</subject><subject>General aspects</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Lymphoma, Non-Hodgkin - pathology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Plasmacytoma - pathology</subject><subject>Thymidine - metabolism</subject><subject>Tumors</subject><issn>0027-8874</issn><issn>1460-2105</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1Lw0AQhhdRaq0ePQo5iLe0s9mv7FGCtWJBoYriZZkkG9yaNDGbgP33Bho6l_fwPAzvDCHXFOYUNFtsd5lbKD6nc6rVCZlSLiGMKIhTMgWIVBjHip-TC--3MIyO-IRMWCwEV3pK-No1dVOXe49Z9o2ty22w6VzVl9i5ehfURfBaoq8w23d1hUFiy9JfkrMCS2-vxpyR9-XDW7IK1y-PT8n9OnSRYl2oLSqQGiIeUyt1TLWANMdMxaktUFNILbe6iBEgtwBCIpdMKyoApQWZsxm5O-xt2vq3t74zlfPZ0AB3tu69UUJLoMAH8WYU-7SyuWlaV2G7N-OZA78dOfoMy6LF4Wn-qGlQVGsxaOFBc76zf0eM7Y-RiilhVp9fhkcbxT42z2bJ_gHKym9T</recordid><startdate>198501</startdate><enddate>198501</enddate><creator>Platica, Micsunica</creator><creator>Hollander, Vincent P.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198501</creationdate><title>Lipopolysaccharide Stimulation of Plasmacytoma Cells</title><author>Platica, Micsunica ; Hollander, Vincent P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i273t-9ea706902481e6981950bdac78befa910be4e9f8a00de0056a46397150a6e06d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Cell Division</topic><topic>Cells, Cultured</topic><topic>Culture Techniques</topic><topic>Dose-Response Relationship, Drug</topic><topic>General aspects</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>Lymphoma, Non-Hodgkin - pathology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Plasmacytoma - pathology</topic><topic>Thymidine - metabolism</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Platica, Micsunica</creatorcontrib><creatorcontrib>Hollander, Vincent P.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>JNCI : Journal of the National Cancer Institute</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Platica, Micsunica</au><au>Hollander, Vincent P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipopolysaccharide Stimulation of Plasmacytoma Cells</atitle><jtitle>JNCI : Journal of the National Cancer Institute</jtitle><addtitle>Journal of the National Cancer Institute</addtitle><date>1985-01</date><risdate>1985</risdate><volume>74</volume><issue>1</issue><spage>197</spage><epage>201</epage><pages>197-201</pages><issn>0027-8874</issn><eissn>1460-2105</eissn><abstract>Various preparations of lipopolysaccharides (LPS) were tested for their effect on 6 plasma tumor cell lines. LPS from Escherichia coli B5:055, Salmonella minnesota 1114, and R7 mutant, as well as the glycolipid from S. minnesota 595 were highly stimulatory on cell suspensions from solid transplantable plasma tumor cells MOPC 315 and MPC11, as measured by thymidine incorporation and cell proliferation. Even nanogram doses were effective. LPS preparations from S. minnesota R5 and endotoxin-free cell wall residues of R5 and R7 mutants of S. minnesota had no stimulatory effect on these cells. In contrast, 4 lines of tissue culture-adapted plasma tumor cells (Adj PC5, HOPC-1, MOPC-21, and MPC11 TC) were not affected by any LPS preparation tested. Lymphosarcoma P1798 cells were also unaffected by these LPS.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>3855479</pmid><doi>10.1093/jnci/74.1.197</doi><tpages>5</tpages></addata></record> |
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| ispartof | JNCI : Journal of the National Cancer Institute, 1985-01, Vol.74 (1), p.197-201 |
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| language | eng |
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| source | Oxford University Press Journals Digital Archive legacy; MEDLINE |
| subjects | Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Cell Division Cells, Cultured Culture Techniques Dose-Response Relationship, Drug General aspects Lipopolysaccharides - pharmacology Lymphoma, Non-Hodgkin - pathology Medical sciences Mice Plasmacytoma - pathology Thymidine - metabolism Tumors |
| title | Lipopolysaccharide Stimulation of Plasmacytoma Cells |
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