Intracerebroventricular injection of naloxone blocks melatonin-dependent brain [3H]flunitrazepam binding

THE pineal hormone melatonin modulates the brain benzodiazepine binding sites and its circadian rhythm. In the present study the effects of intracerebroventricular (i.c.v.) administration of naloxone (10–20 ng), alone or in association with melatonin and/or -endorphin, on [H]flunitrazepam ([H]FNZ) b...

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Veröffentlicht in:	Neuroreport 1993-07, Vol.4 (7), p.987-990
Hauptverfasser:	Gomar, Maria Dolores, Castillo, Jose Luis, del Aguila, Carmen Maria, Fernandez, Begona, Acuna-Castroviejo, Dario
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Cortex Hormones - physiology Animals beta-Endorphin - pharmacology Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Cerebral Cortex - drug effects Cerebral Cortex - metabolism Dose-Response Relationship, Drug Flunitrazepam - pharmacokinetics Fundamental and applied biological sciences. Psychology Hypophysectomy In Vitro Techniques Injections, Intraventricular Male Melatonin - antagonists & inhibitors Melatonin - pharmacology Naloxone - administration & dosage Naloxone - pharmacology Rats Rats, Wistar Receptors, GABA-A - drug effects Receptors, GABA-A - metabolism Vertebrates: nervous system and sense organs
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