Measurement of Vascular Volume in Experimental Rat Tumors by 19F Magnetic Resonance Imaging
RATIONALE AND OBJECTIVES.In-vivo assessment of tumor vascular volume may provide useful information for treatment planning or the assessment of treatment effectiveness. The goals of our study were to measure percent vascular volume in two experimental tumor sublines using F magnetic resonance imagin...
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| Veröffentlicht in: | Investigative radiology 1993-08, Vol.28 (8), p.710-719 |
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| container_title | Investigative radiology |
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| creator | MEYER, KRISTEN L JOSEPH, PETER M MUKHERJI, BISWANATH LIVOLSI, VIRGINIA A LIN, RICHARD |
| description | RATIONALE AND OBJECTIVES.In-vivo assessment of tumor vascular volume may provide useful information for treatment planning or the assessment of treatment effectiveness. The goals of our study were to measure percent vascular volume in two experimental tumor sublines using F magnetic resonance imaging (MRI) and to assess changes in tumor blood volume with growth.
METHODS.An emulsion of perfluorotributylamine (FTBA) was used as a vascular contrast agent for F MRI. The amount of emulsion in the tumor vasculature was measured by F MRI and used to calculate percent vascular volume. A separate ex-vivo study of vascular volume was conducted using the dye Hoechst 33342. A total of five rats were studied by MRI and 14 by the ex-vivo method.
RESULTS.The ranges of percent vascular volume values measured in the imaging and Hoechst dye studies were 2% to 9% and 1.25 to 7%, respectively. A trend toward decreasing percent vascular volume with increasing tumor volume was evident in one tumor subline.
CONCLUSIONS.The quantitative F MRI technique was effective for measuring percent vascular volume and changes in vascular volume with growth. |
| doi_str_mv | 10.1097/00004424-199308000-00012 |
| format | Article |
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METHODS.An emulsion of perfluorotributylamine (FTBA) was used as a vascular contrast agent for F MRI. The amount of emulsion in the tumor vasculature was measured by F MRI and used to calculate percent vascular volume. A separate ex-vivo study of vascular volume was conducted using the dye Hoechst 33342. A total of five rats were studied by MRI and 14 by the ex-vivo method.
RESULTS.The ranges of percent vascular volume values measured in the imaging and Hoechst dye studies were 2% to 9% and 1.25 to 7%, respectively. A trend toward decreasing percent vascular volume with increasing tumor volume was evident in one tumor subline.
CONCLUSIONS.The quantitative F MRI technique was effective for measuring percent vascular volume and changes in vascular volume with growth.</description><identifier>ISSN: 0020-9996</identifier><identifier>EISSN: 1536-0210</identifier><identifier>DOI: 10.1097/00004424-199308000-00012</identifier><identifier>PMID: 8376003</identifier><language>eng</language><publisher>United States: Lippincott-Raven Publishers</publisher><subject>Adenocarcinoma - blood supply ; Adenocarcinoma - diagnosis ; Animals ; Benzimidazoles ; Blood Substitutes ; Calibration ; Fluorescent Dyes ; Fluorine ; Fluorocarbons ; Magnetic Resonance Imaging - instrumentation ; Magnetic Resonance Imaging - methods ; Male ; Models, Structural ; Neoplasm Transplantation ; Prostatic Neoplasms - blood supply ; Prostatic Neoplasms - diagnosis ; Rats ; Tumor Cells, Cultured</subject><ispartof>Investigative radiology, 1993-08, Vol.28 (8), p.710-719</ispartof><rights>Lippincott-Raven Publishers.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2022-25e727a86857f329925787a1111b53115b0432db7942cb4a95f60921b15493de3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8376003$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MEYER, KRISTEN L</creatorcontrib><creatorcontrib>JOSEPH, PETER M</creatorcontrib><creatorcontrib>MUKHERJI, BISWANATH</creatorcontrib><creatorcontrib>LIVOLSI, VIRGINIA A</creatorcontrib><creatorcontrib>LIN, RICHARD</creatorcontrib><title>Measurement of Vascular Volume in Experimental Rat Tumors by 19F Magnetic Resonance Imaging</title><title>Investigative radiology</title><addtitle>Invest Radiol</addtitle><description>RATIONALE AND OBJECTIVES.In-vivo assessment of tumor vascular volume may provide useful information for treatment planning or the assessment of treatment effectiveness. The goals of our study were to measure percent vascular volume in two experimental tumor sublines using F magnetic resonance imaging (MRI) and to assess changes in tumor blood volume with growth.
METHODS.An emulsion of perfluorotributylamine (FTBA) was used as a vascular contrast agent for F MRI. The amount of emulsion in the tumor vasculature was measured by F MRI and used to calculate percent vascular volume. A separate ex-vivo study of vascular volume was conducted using the dye Hoechst 33342. A total of five rats were studied by MRI and 14 by the ex-vivo method.
RESULTS.The ranges of percent vascular volume values measured in the imaging and Hoechst dye studies were 2% to 9% and 1.25 to 7%, respectively. A trend toward decreasing percent vascular volume with increasing tumor volume was evident in one tumor subline.
CONCLUSIONS.The quantitative F MRI technique was effective for measuring percent vascular volume and changes in vascular volume with growth.</description><subject>Adenocarcinoma - blood supply</subject><subject>Adenocarcinoma - diagnosis</subject><subject>Animals</subject><subject>Benzimidazoles</subject><subject>Blood Substitutes</subject><subject>Calibration</subject><subject>Fluorescent Dyes</subject><subject>Fluorine</subject><subject>Fluorocarbons</subject><subject>Magnetic Resonance Imaging - instrumentation</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Models, Structural</subject><subject>Neoplasm Transplantation</subject><subject>Prostatic Neoplasms - blood supply</subject><subject>Prostatic Neoplasms - diagnosis</subject><subject>Rats</subject><subject>Tumor Cells, Cultured</subject><issn>0020-9996</issn><issn>1536-0210</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1PwzAMhiMEGmPwE5By4lbIR9M0RzQNmLQJaRq7cIjSzt0KaTuSVmP_noyN3bBkWZZf2_JjhDAl95Qo-UCCxTGLI6oUJ2nIouCUnaE-FTyJCKPkHPUJYSRSSiWX6Mr7jyBhkvAe6qVcJoTwPnqfgvGdgwrqFjcFXhifd9Y4vGhsVwEuazz63oAr9wJj8cy0eN5VjfM422GqnvDUrGpoyxzPwDe1qXPA48qsynp1jS4KYz3cHOMAvT2N5sOXaPL6PB4-TqKcEcYiJkAyadIkFbLgTCkmZCoNDZYJTqnISMzZMpMqZnkWGyWKhChGMypixZfAB-juMHfjmq8OfKur0udgramh6byWQgnBUh6E6UGYu8Z7B4XehMOM22lK9J6r_uOqT1z1L9fQenvc0WUVLE-NR5ChHh_q28a24Pyn7bbg9BqMbdf6v3fxH7QVgCU</recordid><startdate>199308</startdate><enddate>199308</enddate><creator>MEYER, KRISTEN L</creator><creator>JOSEPH, PETER M</creator><creator>MUKHERJI, BISWANATH</creator><creator>LIVOLSI, VIRGINIA A</creator><creator>LIN, RICHARD</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199308</creationdate><title>Measurement of Vascular Volume in Experimental Rat Tumors by 19F Magnetic Resonance Imaging</title><author>MEYER, KRISTEN L ; JOSEPH, PETER M ; MUKHERJI, BISWANATH ; LIVOLSI, VIRGINIA A ; LIN, RICHARD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2022-25e727a86857f329925787a1111b53115b0432db7942cb4a95f60921b15493de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adenocarcinoma - blood supply</topic><topic>Adenocarcinoma - diagnosis</topic><topic>Animals</topic><topic>Benzimidazoles</topic><topic>Blood Substitutes</topic><topic>Calibration</topic><topic>Fluorescent Dyes</topic><topic>Fluorine</topic><topic>Fluorocarbons</topic><topic>Magnetic Resonance Imaging - instrumentation</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Models, Structural</topic><topic>Neoplasm Transplantation</topic><topic>Prostatic Neoplasms - blood supply</topic><topic>Prostatic Neoplasms - diagnosis</topic><topic>Rats</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MEYER, KRISTEN L</creatorcontrib><creatorcontrib>JOSEPH, PETER M</creatorcontrib><creatorcontrib>MUKHERJI, BISWANATH</creatorcontrib><creatorcontrib>LIVOLSI, VIRGINIA A</creatorcontrib><creatorcontrib>LIN, RICHARD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Investigative radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MEYER, KRISTEN L</au><au>JOSEPH, PETER M</au><au>MUKHERJI, BISWANATH</au><au>LIVOLSI, VIRGINIA A</au><au>LIN, RICHARD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Measurement of Vascular Volume in Experimental Rat Tumors by 19F Magnetic Resonance Imaging</atitle><jtitle>Investigative radiology</jtitle><addtitle>Invest Radiol</addtitle><date>1993-08</date><risdate>1993</risdate><volume>28</volume><issue>8</issue><spage>710</spage><epage>719</epage><pages>710-719</pages><issn>0020-9996</issn><eissn>1536-0210</eissn><abstract>RATIONALE AND OBJECTIVES.In-vivo assessment of tumor vascular volume may provide useful information for treatment planning or the assessment of treatment effectiveness. The goals of our study were to measure percent vascular volume in two experimental tumor sublines using F magnetic resonance imaging (MRI) and to assess changes in tumor blood volume with growth.
METHODS.An emulsion of perfluorotributylamine (FTBA) was used as a vascular contrast agent for F MRI. The amount of emulsion in the tumor vasculature was measured by F MRI and used to calculate percent vascular volume. A separate ex-vivo study of vascular volume was conducted using the dye Hoechst 33342. A total of five rats were studied by MRI and 14 by the ex-vivo method.
RESULTS.The ranges of percent vascular volume values measured in the imaging and Hoechst dye studies were 2% to 9% and 1.25 to 7%, respectively. A trend toward decreasing percent vascular volume with increasing tumor volume was evident in one tumor subline.
CONCLUSIONS.The quantitative F MRI technique was effective for measuring percent vascular volume and changes in vascular volume with growth.</abstract><cop>United States</cop><pub>Lippincott-Raven Publishers</pub><pmid>8376003</pmid><doi>10.1097/00004424-199308000-00012</doi><tpages>10</tpages></addata></record> |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adenocarcinoma - blood supply Adenocarcinoma - diagnosis Animals Benzimidazoles Blood Substitutes Calibration Fluorescent Dyes Fluorine Fluorocarbons Magnetic Resonance Imaging - instrumentation Magnetic Resonance Imaging - methods Male Models, Structural Neoplasm Transplantation Prostatic Neoplasms - blood supply Prostatic Neoplasms - diagnosis Rats Tumor Cells, Cultured |
| title | Measurement of Vascular Volume in Experimental Rat Tumors by 19F Magnetic Resonance Imaging |
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