Abnormal response to IL-5 in B-cell chronic lymphocytic leukemia

In B-cell chronic lymphocytic leukemia, neoplastic B-lymphocytes are arrested in development. Since interleukins are essential for B-cell differentiation, we examined whether B-CLL cells were capable of responding normally to interleukins. Purified B-lymphocytes from B-CLL patients and controls were...

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Veröffentlicht in:	Leukemia research 1993-09, Vol.17 (9), p.777-783
Hauptverfasser:	Hayes, Teresa G., Tan, Xiao-Lin, Moseley, Annemarie B., Huston, Marilyn M., Huston, David P.
Format:	Artikel
Sprache:	eng
Schlagworte:	B-CLL B-lymphocyte differentiation Biological and medical sciences Cell Division - drug effects Hematologic and hematopoietic diseases Humans IL-2 IL-5 Immunoglobulin M - biosynthesis Interleukin-2 - pharmacology Interleukin-5 - pharmacology Leukemia, Lymphocytic, Chronic, B-Cell - immunology Leukemia, Lymphocytic, Chronic, B-Cell - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis MCAT Medical sciences Mitogens - pharmacology Recombinant Proteins - pharmacology SAC Tumor Cells, Cultured
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