Tetrahydroaminoacridine affects the cholinergic function of blood-brain barrier
In rat brain microvessels, tetrahydroaminoacridine (THA) caused a significant inhibition of both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities, in a dose-dependent manner. THA resulted to be a more potent inhibitor of BuChE than AChE. Lineweaver-Burk plots showed that Km (...
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| Veröffentlicht in: | Life sciences (1973) 1993, Vol.53 (14), p.1165-1172 |
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| container_end_page | 1172 |
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| container_issue | 14 |
| container_start_page | 1165 |
| container_title | Life sciences (1973) |
| container_volume | 53 |
| creator | Catalán, R.E. Martínez, A.M. Aragonés, M.D. Miguel, B.G. Hernández, F. Cruz, E. |
| description | In rat brain microvessels, tetrahydroaminoacridine (THA) caused a significant inhibition of both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities, in a dose-dependent manner. THA resulted to be a more potent inhibitor of BuChE than AChE. Lineweaver-Burk plots showed that Km (app) and V were altered by THA, indicating mixed competitive/non-competitite inhivition. The results of the present study also established that the three molecular forms of BuChE (G
1, G
2 and G
4), recently described to be present in brain microvessels, are inhibited after THA treatment. |
| doi_str_mv | 10.1016/0024-3205(93)90553-F |
| format | Article |
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2 and G
4), recently described to be present in brain microvessels, are inhibited after THA treatment.</description><subject>Acetylcholinesterase - drug effects</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood-Brain Barrier - drug effects</subject><subject>Butyrylcholinesterase - drug effects</subject><subject>Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>In Vitro Techniques</subject><subject>Microcirculation - enzymology</subject><subject>Rats</subject><subject>Tacrine - pharmacology</subject><subject>Time Factors</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1LXDEUhkNR7NT2H1S4Cyl1cWu-b7IRRDpWENzoOuTjpBO5c2OTOwX_fTOdYZa6OnDOcw5vniD0leAfBBN5iTHlPaNYfNfsQmMhWL_8gBZEDbrHkpEjtDggH9GnWp8xbtTATtCJYgORDC_QwyPMxa5eQ8l2naZsfUkhTdDZGMHPtZtX0PlVHluv_E6-i5vJzylPXY6dG3MOvSs2TZ2zpSQon9FxtGOFL_t6ip6WPx9vfvX3D7d3N9f3vedkmHsnHZYRLEgpWFCWg3YuCC58BKopH5QSUQauW14sneZqwAzT9jZCveeUnaJvu7svJf_ZQJ3NOlUP42gnyJtqBqEF1QN7FyRSaUKZaiDfgb7kWgtE81LS2pZXQ7DZCjdbm2Zr02hm_gs3y7Z2tr-_cWsIh6W94TY_389t9XaMxU4-1QPGFCZab2Ne7TBo0v42kab6BJOHkEr7BxNyejvHP7kNm8E</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>Catalán, R.E.</creator><creator>Martínez, A.M.</creator><creator>Aragonés, M.D.</creator><creator>Miguel, B.G.</creator><creator>Hernández, F.</creator><creator>Cruz, E.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1993</creationdate><title>Tetrahydroaminoacridine affects the cholinergic function of blood-brain barrier</title><author>Catalán, R.E. ; Martínez, A.M. ; Aragonés, M.D. ; Miguel, B.G. ; Hernández, F. ; Cruz, E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-b6b06feae6653d8a4e9bbd545cfe29247885f6d4955706b9487030218712cc423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Acetylcholinesterase - drug effects</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood-Brain Barrier - drug effects</topic><topic>Butyrylcholinesterase - drug effects</topic><topic>Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>In Vitro Techniques</topic><topic>Microcirculation - enzymology</topic><topic>Rats</topic><topic>Tacrine - pharmacology</topic><topic>Time Factors</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Catalán, R.E.</creatorcontrib><creatorcontrib>Martínez, A.M.</creatorcontrib><creatorcontrib>Aragonés, M.D.</creatorcontrib><creatorcontrib>Miguel, B.G.</creatorcontrib><creatorcontrib>Hernández, F.</creatorcontrib><creatorcontrib>Cruz, E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Catalán, R.E.</au><au>Martínez, A.M.</au><au>Aragonés, M.D.</au><au>Miguel, B.G.</au><au>Hernández, F.</au><au>Cruz, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tetrahydroaminoacridine affects the cholinergic function of blood-brain barrier</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1993</date><risdate>1993</risdate><volume>53</volume><issue>14</issue><spage>1165</spage><epage>1172</epage><pages>1165-1172</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><coden>LIFSAK</coden><abstract>In rat brain microvessels, tetrahydroaminoacridine (THA) caused a significant inhibition of both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities, in a dose-dependent manner. THA resulted to be a more potent inhibitor of BuChE than AChE. Lineweaver-Burk plots showed that Km (app) and V were altered by THA, indicating mixed competitive/non-competitite inhivition. The results of the present study also established that the three molecular forms of BuChE (G
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| subjects | Acetylcholinesterase - drug effects Animals Biological and medical sciences Blood-Brain Barrier - drug effects Butyrylcholinesterase - drug effects Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology In Vitro Techniques Microcirculation - enzymology Rats Tacrine - pharmacology Time Factors Vertebrates: nervous system and sense organs |
| title | Tetrahydroaminoacridine affects the cholinergic function of blood-brain barrier |
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