Anti-tumor effects of adenovirus containing human growth hormone sequences in a mouse model of human ovarian cancer
Women with ovarian cancer have a low survival rate and develop resistance to chemotherapy, so new approaches to treatment are needed. We unexpectedly found administration of a replication-deficient adenovirus containing human growth hormone sequences (AdXGH) was beneficial in a mouse model of human...
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| Veröffentlicht in: | Endocrine 2010-06, Vol.37 (3), p.430-439 |
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| creator | Zhu, Yonglian Fariña, José B. Meshack, Syrus Santoveña, Ana Patel, Shilpa Oliva, Alexis Llabrés, Matias Hodsdon, Michael E. Booth, Carmen J. Dannies, Priscilla S. |
| description | Women with ovarian cancer have a low survival rate and develop resistance to chemotherapy, so new approaches to treatment are needed. We unexpectedly found administration of a replication-deficient adenovirus containing human growth hormone sequences (AdXGH) was beneficial in a mouse model of human ovarian cancer. Intraperitoneal injections of AdXGH prolonged median survival from a mean of 31 ± 1.2 to 40 ± 1.4 days in immunodeficient SCID mice given SKOV3.ip1 human ovarian cancer cells in the peritoneal cavity. Adenovirus containing human prolactin or del32-71growth hormone sequences had no effect. Repeated injection of growth hormone or implantation of tablets with sustained growth hormone release did not increase survival. Control mice had overlapping tumors throughout the peritoneal cavity and liver and frequent lung metastases 24 days after tumor cell injection. Mice that received two injections of AdXGH had no lung metastases. Mice that received four injections had no lung or liver metastases and peritoneal fibrosis. They did not survive longer than mice that received two injections, but they had enlarged livers with hepatocellular changes, indicating that a limitation of increasing the dose is liver toxicity. |
| doi_str_mv | 10.1007/s12020-010-9333-5 |
| format | Article |
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We unexpectedly found administration of a replication-deficient adenovirus containing human growth hormone sequences (AdXGH) was beneficial in a mouse model of human ovarian cancer. Intraperitoneal injections of AdXGH prolonged median survival from a mean of 31 ± 1.2 to 40 ± 1.4 days in immunodeficient SCID mice given SKOV3.ip1 human ovarian cancer cells in the peritoneal cavity. Adenovirus containing human prolactin or del32-71growth hormone sequences had no effect. Repeated injection of growth hormone or implantation of tablets with sustained growth hormone release did not increase survival. Control mice had overlapping tumors throughout the peritoneal cavity and liver and frequent lung metastases 24 days after tumor cell injection. Mice that received two injections of AdXGH had no lung metastases. Mice that received four injections had no lung or liver metastases and peritoneal fibrosis. They did not survive longer than mice that received two injections, but they had enlarged livers with hepatocellular changes, indicating that a limitation of increasing the dose is liver toxicity.</description><identifier>ISSN: 1355-008X</identifier><identifier>EISSN: 1559-0100</identifier><identifier>DOI: 10.1007/s12020-010-9333-5</identifier><identifier>PMID: 20960164</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adenoviridae - genetics ; Animals ; Antineoplastic Agents - therapeutic use ; Base Sequence ; Carboplatin - therapeutic use ; Combined Modality Therapy ; Diabetes ; Disease Models, Animal ; Endocrinology ; Female ; Human Growth Hormone - genetics ; Humanities and Social Sciences ; Humans ; Injections, Intraperitoneal ; Internal Medicine ; Medicine ; Medicine & Public Health ; Mice ; Mice, SCID ; multidisciplinary ; Original Article ; Ovarian Neoplasms - drug therapy ; Ovarian Neoplasms - therapy ; Paclitaxel - therapeutic use ; Science</subject><ispartof>Endocrine, 2010-06, Vol.37 (3), p.430-439</ispartof><rights>Springer Science+Business Media, LLC 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c343t-993e28a8e75d9f93dcd6bd4452b4fcf177e3c549bd60ec588c50db5fcbcdbdda3</citedby><cites>FETCH-LOGICAL-c343t-993e28a8e75d9f93dcd6bd4452b4fcf177e3c549bd60ec588c50db5fcbcdbdda3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12020-010-9333-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12020-010-9333-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20960164$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhu, Yonglian</creatorcontrib><creatorcontrib>Fariña, José B.</creatorcontrib><creatorcontrib>Meshack, Syrus</creatorcontrib><creatorcontrib>Santoveña, Ana</creatorcontrib><creatorcontrib>Patel, Shilpa</creatorcontrib><creatorcontrib>Oliva, Alexis</creatorcontrib><creatorcontrib>Llabrés, Matias</creatorcontrib><creatorcontrib>Hodsdon, Michael E.</creatorcontrib><creatorcontrib>Booth, Carmen J.</creatorcontrib><creatorcontrib>Dannies, Priscilla S.</creatorcontrib><title>Anti-tumor effects of adenovirus containing human growth hormone sequences in a mouse model of human ovarian cancer</title><title>Endocrine</title><addtitle>Endocr</addtitle><addtitle>Endocrine</addtitle><description>Women with ovarian cancer have a low survival rate and develop resistance to chemotherapy, so new approaches to treatment are needed. We unexpectedly found administration of a replication-deficient adenovirus containing human growth hormone sequences (AdXGH) was beneficial in a mouse model of human ovarian cancer. Intraperitoneal injections of AdXGH prolonged median survival from a mean of 31 ± 1.2 to 40 ± 1.4 days in immunodeficient SCID mice given SKOV3.ip1 human ovarian cancer cells in the peritoneal cavity. Adenovirus containing human prolactin or del32-71growth hormone sequences had no effect. Repeated injection of growth hormone or implantation of tablets with sustained growth hormone release did not increase survival. Control mice had overlapping tumors throughout the peritoneal cavity and liver and frequent lung metastases 24 days after tumor cell injection. Mice that received two injections of AdXGH had no lung metastases. Mice that received four injections had no lung or liver metastases and peritoneal fibrosis. They did not survive longer than mice that received two injections, but they had enlarged livers with hepatocellular changes, indicating that a limitation of increasing the dose is liver toxicity.</description><subject>Adenoviridae - genetics</subject><subject>Animals</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Base Sequence</subject><subject>Carboplatin - therapeutic use</subject><subject>Combined Modality Therapy</subject><subject>Diabetes</subject><subject>Disease Models, Animal</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Human Growth Hormone - genetics</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Injections, Intraperitoneal</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mice</subject><subject>Mice, SCID</subject><subject>multidisciplinary</subject><subject>Original Article</subject><subject>Ovarian Neoplasms - drug therapy</subject><subject>Ovarian Neoplasms - therapy</subject><subject>Paclitaxel - therapeutic use</subject><subject>Science</subject><issn>1355-008X</issn><issn>1559-0100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9P3DAQxa0KVLZLP0AvyDdOacd2nMRHhMofaaVeisTNcuzxblYbG-wExLfHq0CPvcyMxr_3NH6E_GDwkwG0vzLjwKECBpUSQlTyC1kxKdVxAydlFlJWAN3jGfmW8x6Ac960X8kZB9UAa-oVyVdhGqppHmOi6D3aKdPoqXEY4suQ5kxtDJMZwhC2dDePJtBtiq_Tju5iGmNAmvF5xmAx0yFQQ8c4ZyzV4eFotEjii0lD6dYUMJ2TU28OGb9_9DV5uPn99_qu2vy5vb--2lRW1GKqlBLIO9NhK53ySjjrmt7VteR97a1nbYvCylr1rgG0suusBNdLb3vreueMWJPLxfcpxXJjnvQ4ZIuHgwlYrtStVJLXsoZCsoW0Keac0OunNIwmvWkG-hi1XqLWJVh9jFrLorn4cJ_7Ed0_xWe2BeALkMtT2GLS-zinUH78H9d3br-MjQ</recordid><startdate>20100601</startdate><enddate>20100601</enddate><creator>Zhu, Yonglian</creator><creator>Fariña, José B.</creator><creator>Meshack, Syrus</creator><creator>Santoveña, Ana</creator><creator>Patel, Shilpa</creator><creator>Oliva, Alexis</creator><creator>Llabrés, Matias</creator><creator>Hodsdon, Michael E.</creator><creator>Booth, Carmen J.</creator><creator>Dannies, Priscilla S.</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100601</creationdate><title>Anti-tumor effects of adenovirus containing human growth hormone sequences in a mouse model of human ovarian cancer</title><author>Zhu, Yonglian ; Fariña, José B. ; Meshack, Syrus ; Santoveña, Ana ; Patel, Shilpa ; Oliva, Alexis ; Llabrés, Matias ; Hodsdon, Michael E. ; Booth, Carmen J. ; Dannies, Priscilla S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c343t-993e28a8e75d9f93dcd6bd4452b4fcf177e3c549bd60ec588c50db5fcbcdbdda3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adenoviridae - genetics</topic><topic>Animals</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Base Sequence</topic><topic>Carboplatin - therapeutic use</topic><topic>Combined Modality Therapy</topic><topic>Diabetes</topic><topic>Disease Models, Animal</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Human Growth Hormone - genetics</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Injections, Intraperitoneal</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mice</topic><topic>Mice, SCID</topic><topic>multidisciplinary</topic><topic>Original Article</topic><topic>Ovarian Neoplasms - drug therapy</topic><topic>Ovarian Neoplasms - therapy</topic><topic>Paclitaxel - therapeutic use</topic><topic>Science</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhu, Yonglian</creatorcontrib><creatorcontrib>Fariña, José B.</creatorcontrib><creatorcontrib>Meshack, Syrus</creatorcontrib><creatorcontrib>Santoveña, Ana</creatorcontrib><creatorcontrib>Patel, Shilpa</creatorcontrib><creatorcontrib>Oliva, Alexis</creatorcontrib><creatorcontrib>Llabrés, Matias</creatorcontrib><creatorcontrib>Hodsdon, Michael E.</creatorcontrib><creatorcontrib>Booth, Carmen J.</creatorcontrib><creatorcontrib>Dannies, Priscilla S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, Yonglian</au><au>Fariña, José B.</au><au>Meshack, Syrus</au><au>Santoveña, Ana</au><au>Patel, Shilpa</au><au>Oliva, Alexis</au><au>Llabrés, Matias</au><au>Hodsdon, Michael E.</au><au>Booth, Carmen J.</au><au>Dannies, Priscilla S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-tumor effects of adenovirus containing human growth hormone sequences in a mouse model of human ovarian cancer</atitle><jtitle>Endocrine</jtitle><stitle>Endocr</stitle><addtitle>Endocrine</addtitle><date>2010-06-01</date><risdate>2010</risdate><volume>37</volume><issue>3</issue><spage>430</spage><epage>439</epage><pages>430-439</pages><issn>1355-008X</issn><eissn>1559-0100</eissn><abstract>Women with ovarian cancer have a low survival rate and develop resistance to chemotherapy, so new approaches to treatment are needed. We unexpectedly found administration of a replication-deficient adenovirus containing human growth hormone sequences (AdXGH) was beneficial in a mouse model of human ovarian cancer. Intraperitoneal injections of AdXGH prolonged median survival from a mean of 31 ± 1.2 to 40 ± 1.4 days in immunodeficient SCID mice given SKOV3.ip1 human ovarian cancer cells in the peritoneal cavity. Adenovirus containing human prolactin or del32-71growth hormone sequences had no effect. Repeated injection of growth hormone or implantation of tablets with sustained growth hormone release did not increase survival. Control mice had overlapping tumors throughout the peritoneal cavity and liver and frequent lung metastases 24 days after tumor cell injection. Mice that received two injections of AdXGH had no lung metastases. Mice that received four injections had no lung or liver metastases and peritoneal fibrosis. 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| subjects | Adenoviridae - genetics Animals Antineoplastic Agents - therapeutic use Base Sequence Carboplatin - therapeutic use Combined Modality Therapy Diabetes Disease Models, Animal Endocrinology Female Human Growth Hormone - genetics Humanities and Social Sciences Humans Injections, Intraperitoneal Internal Medicine Medicine Medicine & Public Health Mice Mice, SCID multidisciplinary Original Article Ovarian Neoplasms - drug therapy Ovarian Neoplasms - therapy Paclitaxel - therapeutic use Science |
| title | Anti-tumor effects of adenovirus containing human growth hormone sequences in a mouse model of human ovarian cancer |
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