DIETARY VITAMIN D AND CALCIUM AND RISK OF COLORECTAL CANCER: A 19-YEAR PROSPECTIVE STUDY IN MEN
Mortality rates from colon cancer in the USA are highest in populations exposed to the least amounts of natural sunlight; differences in endogenous vitamin D production and calcium absorption could be responsible. To investigate this possibility, the association of dietary vitamin D and calcium with...
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| Veröffentlicht in: | The Lancet (British edition) 1985-02, Vol.325 (8424), p.307-309 |
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| creator | Garland, Cedric Barrett-Connor, Elizabeth Rossof, ArthurH Shekelle, RichardB Criqui, MichaelH Paul, Oglesby |
| description | Mortality rates from colon cancer in the USA are highest in populations exposed to the least amounts of natural sunlight; differences in endogenous vitamin D production and calcium absorption could be responsible. To investigate this possibility, the association of dietary vitamin D and calcium with 19-year risk of colorectal cancer was examined in 1954 men who had completed detailed, 28-day dietary histories in the period 1957-59. Risk of colorectal cancer was inversely correlated with dietary vitamin D and calcium. In the quartiles of a combined index of dietary vitamin D and calcium, from lowest to highest, observed risks of colorectal cancer were 38·9, 24·5, 22·5, and 14·3/1000 population. This association remained significant after adjustment for age, daily cigarette consumption, body mass index, ethanol consumption, and percentage of calories obtained from fat. |
| doi_str_mv | 10.1016/S0140-6736(85)91082-7 |
| format | Article |
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To investigate this possibility, the association of dietary vitamin D and calcium with 19-year risk of colorectal cancer was examined in 1954 men who had completed detailed, 28-day dietary histories in the period 1957-59. Risk of colorectal cancer was inversely correlated with dietary vitamin D and calcium. In the quartiles of a combined index of dietary vitamin D and calcium, from lowest to highest, observed risks of colorectal cancer were 38·9, 24·5, 22·5, and 14·3/1000 population. 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This association remained significant after adjustment for age, daily cigarette consumption, body mass index, ethanol consumption, and percentage of calories obtained from fat.</description><subject>Adult</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Calcium</subject><subject>Calcium (dietary)</subject><subject>Calcium absorption</subject><subject>Calcium, Dietary - administration & dosage</subject><subject>Calories</subject><subject>Cancer</subject><subject>Colon</subject><subject>Colon cancer</subject><subject>Colonic Neoplasms - epidemiology</subject><subject>Colonic Neoplasms - etiology</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Diet</subject><subject>Ethanol</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Quartiles</subject><subject>Random Allocation</subject><subject>Rectal Neoplasms - epidemiology</subject><subject>Rectal Neoplasms - etiology</subject><subject>Risk</subject><subject>Risk factors</subject><subject>Vitamin D</subject><subject>Vitamin D - administration & dosage</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkFFLwzAUhYMoOqc_QQgIog_VmzZJW1-kdFWL2ypdJ-4prEkKlW2dzSb4743b2IMvPuXmnnPPvXwIXRC4JUD43QgIBYf7Hr8O2E1IIHAd_wB1CPWpw6j_fog6e8sJOjXmAwAoB3aMjt2A2S7tINFLkyLKJ_gtLaJBOsQ9HA17OI76cToebOo8Hb3g7BHHWT_Lk7iI-lYexkl-jyNMQmeSRDl-zbPRqxXTtwSPinFvgm3WIBmeoaNqOjP6fPd20fgxKeJnp589pXaLIxnwlUN0xQkNpacUcC5DV1USFFWykkpx8LQi3P6CstSl7xFNSsp8UJ7UID0KU6-Lrra5y7b5XGuzEvPaSD2bTRe6WRvhs5C5xOPWePnH-NGs24W9TbguhCEPOWfWxbYu2TbGtLoSy7aeT9tvQUD84hcb_OKXrQiY2OAXvp272KWvy7lW-6kdb6s_bHVtWXzVuhVG1nohtapbLVdCNfU_G34APLKLPw</recordid><startdate>19850209</startdate><enddate>19850209</enddate><creator>Garland, Cedric</creator><creator>Barrett-Connor, Elizabeth</creator><creator>Rossof, ArthurH</creator><creator>Shekelle, RichardB</creator><creator>Criqui, MichaelH</creator><creator>Paul, Oglesby</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>ASE</scope><scope>C1K</scope><scope>FPQ</scope><scope>H94</scope><scope>K6X</scope><scope>K9.</scope><scope>KB~</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>19850209</creationdate><title>DIETARY VITAMIN D AND CALCIUM AND RISK OF COLORECTAL CANCER: A 19-YEAR PROSPECTIVE STUDY IN MEN</title><author>Garland, Cedric ; 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| subjects | Adult Body mass index Body size Calcium Calcium (dietary) Calcium absorption Calcium, Dietary - administration & dosage Calories Cancer Colon Colon cancer Colonic Neoplasms - epidemiology Colonic Neoplasms - etiology Colorectal cancer Colorectal carcinoma Diet Ethanol Health risk assessment Humans Male Middle Aged Prospective Studies Quartiles Random Allocation Rectal Neoplasms - epidemiology Rectal Neoplasms - etiology Risk Risk factors Vitamin D Vitamin D - administration & dosage |
| title | DIETARY VITAMIN D AND CALCIUM AND RISK OF COLORECTAL CANCER: A 19-YEAR PROSPECTIVE STUDY IN MEN |
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