Evaluation of myocardial preservation using 31P NMR
The purpose of this study was (1) to monitor myocardial high-energy phosphate content and recovery of left ventricular (LV) contractile function following normothermic graded cardiac ischemia and single-dose hypothermic potassium cardioplegia, and (2) to assess the temporal limits of LV functional r...
Gespeichert in:
| Veröffentlicht in: | The Journal of surgical research 1985-02, Vol.38 (2), p.154-161 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 161 |
|---|---|
| container_issue | 2 |
| container_start_page | 154 |
| container_title | The Journal of surgical research |
| container_volume | 38 |
| creator | Whitman, Glenn J.R. Roth, Russell A. Kieval, Robert S. Harken, Alden H. |
| description | The purpose of this study was (1) to monitor myocardial high-energy phosphate content and recovery of left ventricular (LV) contractile function following normothermic graded cardiac ischemia and single-dose hypothermic potassium cardioplegia, and (2) to assess the temporal limits of LV functional recovery during single-dose cardioplegia maintained at 17°C. Rabbit hearts (30) were perfused, equipped with an LV balloon, paced at 240 beats/min, and placed in a nuclear magnetic resonance (NMR) magnet. Hearts underwent either graded, global normothermic ischemia or potassium cardioplegia arrest maintained at 17°C for 1 hr. Myocardial high-energy phosphate level, LV contractility, and temperature were monitored continuously. Phosphocreatine (PCr) fell to 10 ± 2, 2 ± 1, and 0% of control and ATP to 70 ± 3, 19 ± 7, and 0% of control at 10, 40, and 60 min of 37°C ischemia. After 1 hr of reperfusion, regression analysis of final developed pressure (DP) on end ischemic ATP (EIATP) content revealed: DP = 1.02 EIATP + 18 (
r = 0.95). Following single-dose cardioplegia, maintained at 17°C, PCr fell to 16 ± 3% of control at 60 min while ATP fell only to 92 ± 5% control. With reperfusion, recovery of DP was 100%. It was concluded that (1) PCr serves as an energy buffer for ATP, (2) EIATP predicts recovery of LV function, (3) single-dose cardioplegia
maintained at 17°C provides complete myocardial preservation for up to 60 min. |
| doi_str_mv | 10.1016/0022-4804(85)90022-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_75950808</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0022480485900228</els_id><sourcerecordid>75950808</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2334-192f6d05b1d169f641e1cfada694493772cf61e71586f90776f31e1c5f8ff62e3</originalsourceid><addsrcrecordid>eNp9kMtKAzEUhoMotV7eQGEWIroYTSaZXDaClHqBekF0HdLMiUTmUpNOoW_vTDt06epw-L__cPgQOiP4hmDCbzHOspRJzK5kfq02m9xDY4JVnkou6D4a75BDdBTjD-52JegIjajiUgo2RnS6MmVrlr6pk8Yl1bqxJhTelMkiQISw2kZt9PV3Qsl78vrycYIOnCkjnA7zGH09TD8nT-ns7fF5cj9LbUYpS4nKHC9wPicF4cpxRoBYZwrDFWOKCpFZxwkIkkvuFBaCO9ojuZPO8QzoMbrc3l2E5reFuNSVjxbK0tTQtFGLXOVYYtmBbAva0MQYwOlF8JUJa02w7l3pXoTuRWiZ640r3dfOh_vtvIJiVxrkdPnFkJtoTemCqa2PO0xhQmWmOuxui0HnYuUh6Gg91BYKH8AuddH4___4A0GVgrU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>75950808</pqid></control><display><type>article</type><title>Evaluation of myocardial preservation using 31P NMR</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Whitman, Glenn J.R. ; Roth, Russell A. ; Kieval, Robert S. ; Harken, Alden H.</creator><creatorcontrib>Whitman, Glenn J.R. ; Roth, Russell A. ; Kieval, Robert S. ; Harken, Alden H.</creatorcontrib><description>The purpose of this study was (1) to monitor myocardial high-energy phosphate content and recovery of left ventricular (LV) contractile function following normothermic graded cardiac ischemia and single-dose hypothermic potassium cardioplegia, and (2) to assess the temporal limits of LV functional recovery during single-dose cardioplegia maintained at 17°C. Rabbit hearts (30) were perfused, equipped with an LV balloon, paced at 240 beats/min, and placed in a nuclear magnetic resonance (NMR) magnet. Hearts underwent either graded, global normothermic ischemia or potassium cardioplegia arrest maintained at 17°C for 1 hr. Myocardial high-energy phosphate level, LV contractility, and temperature were monitored continuously. Phosphocreatine (PCr) fell to 10 ± 2, 2 ± 1, and 0% of control and ATP to 70 ± 3, 19 ± 7, and 0% of control at 10, 40, and 60 min of 37°C ischemia. After 1 hr of reperfusion, regression analysis of final developed pressure (DP) on end ischemic ATP (EIATP) content revealed: DP = 1.02 EIATP + 18 (
r = 0.95). Following single-dose cardioplegia, maintained at 17°C, PCr fell to 16 ± 3% of control at 60 min while ATP fell only to 92 ± 5% control. With reperfusion, recovery of DP was 100%. It was concluded that (1) PCr serves as an energy buffer for ATP, (2) EIATP predicts recovery of LV function, (3) single-dose cardioplegia
maintained at 17°C provides complete myocardial preservation for up to 60 min.</description><identifier>ISSN: 0022-4804</identifier><identifier>EISSN: 1095-8673</identifier><identifier>DOI: 10.1016/0022-4804(85)90022-8</identifier><identifier>PMID: 3968874</identifier><identifier>CODEN: JSGRA2</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adenosine Triphosphate - metabolism ; Anesthesia ; Anesthesia depending on type of surgery ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Animals ; Biological and medical sciences ; Coronary Disease - metabolism ; Coronary Disease - physiopathology ; Evaluation Studies as Topic ; Heart - physiopathology ; Heart Ventricles ; Hydrogen-Ion Concentration ; Intracellular Fluid - metabolism ; Magnetic Resonance Spectroscopy ; Male ; Medical sciences ; Monitoring, Physiologic - methods ; Myocardium - metabolism ; Organ Preservation ; Phosphates - metabolism ; Phosphocreatine - metabolism ; Phosphorus ; Rabbits ; Thoracic and cardiovascular surgery. Cardiopulmonary bypass</subject><ispartof>The Journal of surgical research, 1985-02, Vol.38 (2), p.154-161</ispartof><rights>1985</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2334-192f6d05b1d169f641e1cfada694493772cf61e71586f90776f31e1c5f8ff62e3</citedby><cites>FETCH-LOGICAL-c2334-192f6d05b1d169f641e1cfada694493772cf61e71586f90776f31e1c5f8ff62e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0022480485900228$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9013829$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3968874$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Whitman, Glenn J.R.</creatorcontrib><creatorcontrib>Roth, Russell A.</creatorcontrib><creatorcontrib>Kieval, Robert S.</creatorcontrib><creatorcontrib>Harken, Alden H.</creatorcontrib><title>Evaluation of myocardial preservation using 31P NMR</title><title>The Journal of surgical research</title><addtitle>J Surg Res</addtitle><description>The purpose of this study was (1) to monitor myocardial high-energy phosphate content and recovery of left ventricular (LV) contractile function following normothermic graded cardiac ischemia and single-dose hypothermic potassium cardioplegia, and (2) to assess the temporal limits of LV functional recovery during single-dose cardioplegia maintained at 17°C. Rabbit hearts (30) were perfused, equipped with an LV balloon, paced at 240 beats/min, and placed in a nuclear magnetic resonance (NMR) magnet. Hearts underwent either graded, global normothermic ischemia or potassium cardioplegia arrest maintained at 17°C for 1 hr. Myocardial high-energy phosphate level, LV contractility, and temperature were monitored continuously. Phosphocreatine (PCr) fell to 10 ± 2, 2 ± 1, and 0% of control and ATP to 70 ± 3, 19 ± 7, and 0% of control at 10, 40, and 60 min of 37°C ischemia. After 1 hr of reperfusion, regression analysis of final developed pressure (DP) on end ischemic ATP (EIATP) content revealed: DP = 1.02 EIATP + 18 (
r = 0.95). Following single-dose cardioplegia, maintained at 17°C, PCr fell to 16 ± 3% of control at 60 min while ATP fell only to 92 ± 5% control. With reperfusion, recovery of DP was 100%. It was concluded that (1) PCr serves as an energy buffer for ATP, (2) EIATP predicts recovery of LV function, (3) single-dose cardioplegia
maintained at 17°C provides complete myocardial preservation for up to 60 min.</description><subject>Adenosine Triphosphate - metabolism</subject><subject>Anesthesia</subject><subject>Anesthesia depending on type of surgery</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Coronary Disease - metabolism</subject><subject>Coronary Disease - physiopathology</subject><subject>Evaluation Studies as Topic</subject><subject>Heart - physiopathology</subject><subject>Heart Ventricles</subject><subject>Hydrogen-Ion Concentration</subject><subject>Intracellular Fluid - metabolism</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Monitoring, Physiologic - methods</subject><subject>Myocardium - metabolism</subject><subject>Organ Preservation</subject><subject>Phosphates - metabolism</subject><subject>Phosphocreatine - metabolism</subject><subject>Phosphorus</subject><subject>Rabbits</subject><subject>Thoracic and cardiovascular surgery. Cardiopulmonary bypass</subject><issn>0022-4804</issn><issn>1095-8673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKAzEUhoMotV7eQGEWIroYTSaZXDaClHqBekF0HdLMiUTmUpNOoW_vTDt06epw-L__cPgQOiP4hmDCbzHOspRJzK5kfq02m9xDY4JVnkou6D4a75BDdBTjD-52JegIjajiUgo2RnS6MmVrlr6pk8Yl1bqxJhTelMkiQISw2kZt9PV3Qsl78vrycYIOnCkjnA7zGH09TD8nT-ns7fF5cj9LbUYpS4nKHC9wPicF4cpxRoBYZwrDFWOKCpFZxwkIkkvuFBaCO9ojuZPO8QzoMbrc3l2E5reFuNSVjxbK0tTQtFGLXOVYYtmBbAva0MQYwOlF8JUJa02w7l3pXoTuRWiZ640r3dfOh_vtvIJiVxrkdPnFkJtoTemCqa2PO0xhQmWmOuxui0HnYuUh6Gg91BYKH8AuddH4___4A0GVgrU</recordid><startdate>198502</startdate><enddate>198502</enddate><creator>Whitman, Glenn J.R.</creator><creator>Roth, Russell A.</creator><creator>Kieval, Robert S.</creator><creator>Harken, Alden H.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198502</creationdate><title>Evaluation of myocardial preservation using 31P NMR</title><author>Whitman, Glenn J.R. ; Roth, Russell A. ; Kieval, Robert S. ; Harken, Alden H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2334-192f6d05b1d169f641e1cfada694493772cf61e71586f90776f31e1c5f8ff62e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adenosine Triphosphate - metabolism</topic><topic>Anesthesia</topic><topic>Anesthesia depending on type of surgery</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Coronary Disease - metabolism</topic><topic>Coronary Disease - physiopathology</topic><topic>Evaluation Studies as Topic</topic><topic>Heart - physiopathology</topic><topic>Heart Ventricles</topic><topic>Hydrogen-Ion Concentration</topic><topic>Intracellular Fluid - metabolism</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Monitoring, Physiologic - methods</topic><topic>Myocardium - metabolism</topic><topic>Organ Preservation</topic><topic>Phosphates - metabolism</topic><topic>Phosphocreatine - metabolism</topic><topic>Phosphorus</topic><topic>Rabbits</topic><topic>Thoracic and cardiovascular surgery. Cardiopulmonary bypass</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Whitman, Glenn J.R.</creatorcontrib><creatorcontrib>Roth, Russell A.</creatorcontrib><creatorcontrib>Kieval, Robert S.</creatorcontrib><creatorcontrib>Harken, Alden H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of surgical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Whitman, Glenn J.R.</au><au>Roth, Russell A.</au><au>Kieval, Robert S.</au><au>Harken, Alden H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of myocardial preservation using 31P NMR</atitle><jtitle>The Journal of surgical research</jtitle><addtitle>J Surg Res</addtitle><date>1985-02</date><risdate>1985</risdate><volume>38</volume><issue>2</issue><spage>154</spage><epage>161</epage><pages>154-161</pages><issn>0022-4804</issn><eissn>1095-8673</eissn><coden>JSGRA2</coden><abstract>The purpose of this study was (1) to monitor myocardial high-energy phosphate content and recovery of left ventricular (LV) contractile function following normothermic graded cardiac ischemia and single-dose hypothermic potassium cardioplegia, and (2) to assess the temporal limits of LV functional recovery during single-dose cardioplegia maintained at 17°C. Rabbit hearts (30) were perfused, equipped with an LV balloon, paced at 240 beats/min, and placed in a nuclear magnetic resonance (NMR) magnet. Hearts underwent either graded, global normothermic ischemia or potassium cardioplegia arrest maintained at 17°C for 1 hr. Myocardial high-energy phosphate level, LV contractility, and temperature were monitored continuously. Phosphocreatine (PCr) fell to 10 ± 2, 2 ± 1, and 0% of control and ATP to 70 ± 3, 19 ± 7, and 0% of control at 10, 40, and 60 min of 37°C ischemia. After 1 hr of reperfusion, regression analysis of final developed pressure (DP) on end ischemic ATP (EIATP) content revealed: DP = 1.02 EIATP + 18 (
r = 0.95). Following single-dose cardioplegia, maintained at 17°C, PCr fell to 16 ± 3% of control at 60 min while ATP fell only to 92 ± 5% control. With reperfusion, recovery of DP was 100%. It was concluded that (1) PCr serves as an energy buffer for ATP, (2) EIATP predicts recovery of LV function, (3) single-dose cardioplegia
maintained at 17°C provides complete myocardial preservation for up to 60 min.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>3968874</pmid><doi>10.1016/0022-4804(85)90022-8</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-4804 |
| ispartof | The Journal of surgical research, 1985-02, Vol.38 (2), p.154-161 |
| issn | 0022-4804 1095-8673 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75950808 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adenosine Triphosphate - metabolism Anesthesia Anesthesia depending on type of surgery Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Coronary Disease - metabolism Coronary Disease - physiopathology Evaluation Studies as Topic Heart - physiopathology Heart Ventricles Hydrogen-Ion Concentration Intracellular Fluid - metabolism Magnetic Resonance Spectroscopy Male Medical sciences Monitoring, Physiologic - methods Myocardium - metabolism Organ Preservation Phosphates - metabolism Phosphocreatine - metabolism Phosphorus Rabbits Thoracic and cardiovascular surgery. Cardiopulmonary bypass |
| title | Evaluation of myocardial preservation using 31P NMR |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T05%3A57%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evaluation%20of%20myocardial%20preservation%20using%2031P%20NMR&rft.jtitle=The%20Journal%20of%20surgical%20research&rft.au=Whitman,%20Glenn%20J.R.&rft.date=1985-02&rft.volume=38&rft.issue=2&rft.spage=154&rft.epage=161&rft.pages=154-161&rft.issn=0022-4804&rft.eissn=1095-8673&rft.coden=JSGRA2&rft_id=info:doi/10.1016/0022-4804(85)90022-8&rft_dat=%3Cproquest_cross%3E75950808%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=75950808&rft_id=info:pmid/3968874&rft_els_id=0022480485900228&rfr_iscdi=true |