Hepatitis B virus DNA in serum from patients with acute hepatitis B
Sera from 77 consecutive patients with acute type B hepatitis were examined for hepatitis B virus DNA (HBV DNA) by a spot hybridization method. The median follow‐up time was 8 months (range, 1 week to 3 years). HBV DNA was detected in 26 (34%) patients on admission to the hospital. A significant pos...
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| Veröffentlicht in: | Hepatology (Baltimore, Md.) Md.), 1985-01, Vol.5 (1), p.10-13 |
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| container_title | Hepatology (Baltimore, Md.) |
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| creator | Krogsgaard, Kim Kryger, Peter Aldershvile, Jan Andersson, Poul Brechot, Christian |
| description | Sera from 77 consecutive patients with acute type B hepatitis were examined for hepatitis B virus DNA (HBV DNA) by a spot hybridization method. The median follow‐up time was 8 months (range, 1 week to 3 years). HBV DNA was detected in 26 (34%) patients on admission to the hospital. A significant positive correlation was found between short duration of symptoms and the presence of HBV DNA (p < 0.025). Twenty‐four (46%) of 52 HBeAg‐positive patients were HBV DNA positive compared to 2 HBV DNA‐positive patients of 25 HBeAg‐negative patients (8%) (p < 0.001). Four HBeAg‐negative patients had serum HBV DNA initially or during follow‐up; three had anti‐HBe. Six of 77 patients with acute type B hepatitis (8%) became chronic HBsAg carriers, and HBV DNA was detectable from 5 months to more than 3 years after onset of symptoms. The presence of serum HBV DNA for more than 8 weeks after initial symptoms may predict development of a chronic HBsAg carrier state. In none of the chronic carriers was serum HBV DNA present after clearing of HBeAg. |
| doi_str_mv | 10.1002/hep.1840050104 |
| format | Article |
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The median follow‐up time was 8 months (range, 1 week to 3 years). HBV DNA was detected in 26 (34%) patients on admission to the hospital. A significant positive correlation was found between short duration of symptoms and the presence of HBV DNA (p < 0.025). Twenty‐four (46%) of 52 HBeAg‐positive patients were HBV DNA positive compared to 2 HBV DNA‐positive patients of 25 HBeAg‐negative patients (8%) (p < 0.001). Four HBeAg‐negative patients had serum HBV DNA initially or during follow‐up; three had anti‐HBe. Six of 77 patients with acute type B hepatitis (8%) became chronic HBsAg carriers, and HBV DNA was detectable from 5 months to more than 3 years after onset of symptoms. The presence of serum HBV DNA for more than 8 weeks after initial symptoms may predict development of a chronic HBsAg carrier state. In none of the chronic carriers was serum HBV DNA present after clearing of HBeAg.</description><identifier>ISSN: 0270-9139</identifier><identifier>EISSN: 1527-3350</identifier><identifier>DOI: 10.1002/hep.1840050104</identifier><identifier>PMID: 3967850</identifier><identifier>CODEN: HPTLD9</identifier><language>eng</language><publisher>Philadelphia, PA: W.B. Saunders</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; DNA, Viral - blood ; Female ; Hepatitis B - blood ; Hepatitis B e Antigens - analysis ; Hepatitis B Surface Antigens - analysis ; Hepatitis B virus - analysis ; Human viral diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; Viral diseases ; Viral hepatitis</subject><ispartof>Hepatology (Baltimore, Md.), 1985-01, Vol.5 (1), p.10-13</ispartof><rights>Copyright © 1985 American Association for the Study of Liver Diseases</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4094-4e0878257d85789ff196f4bfb2beab3fb230a0a6de160e27fbb888e0fdaa7e333</citedby><cites>FETCH-LOGICAL-c4094-4e0878257d85789ff196f4bfb2beab3fb230a0a6de160e27fbb888e0fdaa7e333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhep.1840050104$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhep.1840050104$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,4012,27910,27911,27912,45561,45562</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9198259$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3967850$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Krogsgaard, Kim</creatorcontrib><creatorcontrib>Kryger, Peter</creatorcontrib><creatorcontrib>Aldershvile, Jan</creatorcontrib><creatorcontrib>Andersson, Poul</creatorcontrib><creatorcontrib>Brechot, Christian</creatorcontrib><title>Hepatitis B virus DNA in serum from patients with acute hepatitis B</title><title>Hepatology (Baltimore, Md.)</title><addtitle>Hepatology</addtitle><description>Sera from 77 consecutive patients with acute type B hepatitis were examined for hepatitis B virus DNA (HBV DNA) by a spot hybridization method. The median follow‐up time was 8 months (range, 1 week to 3 years). HBV DNA was detected in 26 (34%) patients on admission to the hospital. A significant positive correlation was found between short duration of symptoms and the presence of HBV DNA (p < 0.025). Twenty‐four (46%) of 52 HBeAg‐positive patients were HBV DNA positive compared to 2 HBV DNA‐positive patients of 25 HBeAg‐negative patients (8%) (p < 0.001). Four HBeAg‐negative patients had serum HBV DNA initially or during follow‐up; three had anti‐HBe. Six of 77 patients with acute type B hepatitis (8%) became chronic HBsAg carriers, and HBV DNA was detectable from 5 months to more than 3 years after onset of symptoms. The presence of serum HBV DNA for more than 8 weeks after initial symptoms may predict development of a chronic HBsAg carrier state. In none of the chronic carriers was serum HBV DNA present after clearing of HBeAg.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>DNA, Viral - blood</subject><subject>Female</subject><subject>Hepatitis B - blood</subject><subject>Hepatitis B e Antigens - analysis</subject><subject>Hepatitis B Surface Antigens - analysis</subject><subject>Hepatitis B virus - analysis</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><issn>0270-9139</issn><issn>1527-3350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDFPwzAQhS0EKqWwsiF5QGwp5zip7bGUQpEqYIA5ctKzapQ0wU6o-u9x1aplY3rD--7d3SPkmsGQAcT3S2yGTCYAKTBITkifpbGIOE_hlPQhFhApxtU5ufD-CwBUEsse6XE1EjKFPpnMsNGtba2nD_THus7Tx9cxtSvq0XUVNa6u6JbAVevp2rZLqouuRbo8zl2SM6NLj1d7HZDPp-nHZBbN355fJuN5VCRhb5QgSCHjVCxkKqQyhqmRSXKTxznqnAfloEGPFshGgLEweS6lRDALrQVyzgfkbpfbuPq7Q99mlfUFlqVeYd35TKQqlBBDAIc7sHC19w5N1jhbabfJGGTb1rJwfXZsLQzc7JO7vMLFAd_XFPzbva99oUvj9Kqw_oAppsJfKmBqh61tiZt_lmaz6fufE34BDfyEkg</recordid><startdate>198501</startdate><enddate>198501</enddate><creator>Krogsgaard, Kim</creator><creator>Kryger, Peter</creator><creator>Aldershvile, Jan</creator><creator>Andersson, Poul</creator><creator>Brechot, Christian</creator><general>W.B. 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The median follow‐up time was 8 months (range, 1 week to 3 years). HBV DNA was detected in 26 (34%) patients on admission to the hospital. A significant positive correlation was found between short duration of symptoms and the presence of HBV DNA (p < 0.025). Twenty‐four (46%) of 52 HBeAg‐positive patients were HBV DNA positive compared to 2 HBV DNA‐positive patients of 25 HBeAg‐negative patients (8%) (p < 0.001). Four HBeAg‐negative patients had serum HBV DNA initially or during follow‐up; three had anti‐HBe. Six of 77 patients with acute type B hepatitis (8%) became chronic HBsAg carriers, and HBV DNA was detectable from 5 months to more than 3 years after onset of symptoms. The presence of serum HBV DNA for more than 8 weeks after initial symptoms may predict development of a chronic HBsAg carrier state. In none of the chronic carriers was serum HBV DNA present after clearing of HBeAg.</abstract><cop>Philadelphia, PA</cop><pub>W.B. Saunders</pub><pmid>3967850</pmid><doi>10.1002/hep.1840050104</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Hepatology (Baltimore, Md.), 1985-01, Vol.5 (1), p.10-13 |
| issn | 0270-9139 1527-3350 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adult Aged Biological and medical sciences DNA, Viral - blood Female Hepatitis B - blood Hepatitis B e Antigens - analysis Hepatitis B Surface Antigens - analysis Hepatitis B virus - analysis Human viral diseases Humans Infectious diseases Male Medical sciences Middle Aged Viral diseases Viral hepatitis |
| title | Hepatitis B virus DNA in serum from patients with acute hepatitis B |
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