Regeneration across ‘stepping-stone’ nerve grafts
The ability of small nerve segments interposed between synthetic conduits to increase the total nerve gap distance across which successful nerve regeneration would occur was studied. Fifty adult male Lewis rats were randomized into five groups. In Group I a segment of resected sciatic nerve was repa...
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| Veröffentlicht in: | Brain research 1993-08, Vol.618 (2), p.196-202 |
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| creator | Maeda, Tomoo Mackinnon, Susan E. Best, Timothy J. Evans, Peter J. Hunter, Daniel A. Rajiv Midha, R.T. |
| description | The ability of small nerve segments interposed between synthetic conduits to increase the total nerve gap distance across which successful nerve regeneration would occur was studied. Fifty adult male Lewis rats were randomized into five groups. In Group I a segment of resected sciatic nerve was repaired by a nerve graft. Group II had alternating silicone tubing/nerve graft/silicone tubing replacement of the resected nerve segment (single stepping stone group). Group III had silicone tubing/nerve graft/silicone tubing/nerve graft/silicone tubing repair of the nerve deficit (double stepping stone). Group IV had a single long silicone conduit repair. Group V control underwent a sham operation. Nerve regeneration was evaluated using walking track pattern analysis, electrophysiologic assessment and histomorphological evaluation. ‘Stepping stone nerve grafts’ enhanced regeneration across nerve gaps in comparison to a single long conduit, but were inferior to a single long nerve graft. In the repair of long nerve gaps, the use of multiple short conduits with interposed short nerve segments could provide a source of trophic factors to enhance regeneration. |
| doi_str_mv | 10.1016/0006-8993(93)91266-U |
| format | Article |
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Fifty adult male Lewis rats were randomized into five groups. In Group I a segment of resected sciatic nerve was repaired by a nerve graft. Group II had alternating silicone tubing/nerve graft/silicone tubing replacement of the resected nerve segment (single stepping stone group). Group III had silicone tubing/nerve graft/silicone tubing/nerve graft/silicone tubing repair of the nerve deficit (double stepping stone). Group IV had a single long silicone conduit repair. Group V control underwent a sham operation. Nerve regeneration was evaluated using walking track pattern analysis, electrophysiologic assessment and histomorphological evaluation. ‘Stepping stone nerve grafts’ enhanced regeneration across nerve gaps in comparison to a single long conduit, but were inferior to a single long nerve graft. In the repair of long nerve gaps, the use of multiple short conduits with interposed short nerve segments could provide a source of trophic factors to enhance regeneration.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(93)91266-U</identifier><identifier>PMID: 8374752</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; Body Weight - physiology ; Conduit ; Electrophysiology ; Fundamental and applied biological sciences. Psychology ; Isolated neuron and nerve. Neuroglia ; Male ; Nerve Fibers, Myelinated - physiology ; Nerve graft ; Nerve regeneration ; Nerve Regeneration - physiology ; Neurotropism ; Peripheral nerve ; Peripheral Nerves - anatomy & histology ; Peripheral Nerves - physiology ; Peripheral Nerves - transplantation ; Rats ; Rats, Inbred Lew ; Sciatic Nerve - anatomy & histology ; Sciatic Nerve - physiology ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 1993-08, Vol.618 (2), p.196-202</ispartof><rights>1993 Elsevier Science Publishers B.V. All rights reserved</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-1399e2264007a10dfec972edd90a9a8c1dfbde88d663575f7066c95fa34504d63</citedby><cites>FETCH-LOGICAL-c446t-1399e2264007a10dfec972edd90a9a8c1dfbde88d663575f7066c95fa34504d63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(93)91266-U$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4817639$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8374752$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maeda, Tomoo</creatorcontrib><creatorcontrib>Mackinnon, Susan E.</creatorcontrib><creatorcontrib>Best, Timothy J.</creatorcontrib><creatorcontrib>Evans, Peter J.</creatorcontrib><creatorcontrib>Hunter, Daniel A.</creatorcontrib><creatorcontrib>Rajiv Midha, R.T.</creatorcontrib><title>Regeneration across ‘stepping-stone’ nerve grafts</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The ability of small nerve segments interposed between synthetic conduits to increase the total nerve gap distance across which successful nerve regeneration would occur was studied. Fifty adult male Lewis rats were randomized into five groups. In Group I a segment of resected sciatic nerve was repaired by a nerve graft. Group II had alternating silicone tubing/nerve graft/silicone tubing replacement of the resected nerve segment (single stepping stone group). Group III had silicone tubing/nerve graft/silicone tubing/nerve graft/silicone tubing repair of the nerve deficit (double stepping stone). Group IV had a single long silicone conduit repair. Group V control underwent a sham operation. Nerve regeneration was evaluated using walking track pattern analysis, electrophysiologic assessment and histomorphological evaluation. ‘Stepping stone nerve grafts’ enhanced regeneration across nerve gaps in comparison to a single long conduit, but were inferior to a single long nerve graft. In the repair of long nerve gaps, the use of multiple short conduits with interposed short nerve segments could provide a source of trophic factors to enhance regeneration.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Weight - physiology</subject><subject>Conduit</subject><subject>Electrophysiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Isolated neuron and nerve. Neuroglia</subject><subject>Male</subject><subject>Nerve Fibers, Myelinated - physiology</subject><subject>Nerve graft</subject><subject>Nerve regeneration</subject><subject>Nerve Regeneration - physiology</subject><subject>Neurotropism</subject><subject>Peripheral nerve</subject><subject>Peripheral Nerves - anatomy & histology</subject><subject>Peripheral Nerves - physiology</subject><subject>Peripheral Nerves - transplantation</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>Sciatic Nerve - anatomy & histology</subject><subject>Sciatic Nerve - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1KAzEQgIMotVbfQKEHET2sJptsfi6CFP-gIIg9hzSZLZHtbk22BW99DH29Pom7dulRYWAY5pth5kPolOBrggm_wRjzRCpFLxW9UiTlPJnsoT6RIk14yvA-6u-QQ3QU43tTUqpwD_UkFUxkaR9lrzCDEoKpfVUOjQ1VjMPN-ivWsFj4cpbEuiphs_4eNtAKhrNg8joeo4PcFBFOujxAk4f7t9FTMn55fB7djRPLGK8TQpWCNOUMY2EIdjlYJVJwTmGjjLTE5VMHUjrOaSayXGDOrcpyQ1mGmeN0gC62exeh-lhCrPXcRwtFYUqollGLTDEpU_IvSLhgiuGsAdkW_P00QK4Xwc9N-NQE61arbp3p1pluo9WqJ83YWbd_OZ2D2w11Hpv-edc30ZoiD6a0Pu4wJongVDXY7RaDRtrKQ9DReigtOB_A1tpV_u87fgCz6ZSc</recordid><startdate>19930806</startdate><enddate>19930806</enddate><creator>Maeda, Tomoo</creator><creator>Mackinnon, Susan E.</creator><creator>Best, Timothy J.</creator><creator>Evans, Peter J.</creator><creator>Hunter, Daniel A.</creator><creator>Rajiv Midha, R.T.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19930806</creationdate><title>Regeneration across ‘stepping-stone’ nerve grafts</title><author>Maeda, Tomoo ; Mackinnon, Susan E. ; Best, Timothy J. ; Evans, Peter J. ; Hunter, Daniel A. ; Rajiv Midha, R.T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-1399e2264007a10dfec972edd90a9a8c1dfbde88d663575f7066c95fa34504d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Weight - physiology</topic><topic>Conduit</topic><topic>Electrophysiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Isolated neuron and nerve. Neuroglia</topic><topic>Male</topic><topic>Nerve Fibers, Myelinated - physiology</topic><topic>Nerve graft</topic><topic>Nerve regeneration</topic><topic>Nerve Regeneration - physiology</topic><topic>Neurotropism</topic><topic>Peripheral nerve</topic><topic>Peripheral Nerves - anatomy & histology</topic><topic>Peripheral Nerves - physiology</topic><topic>Peripheral Nerves - transplantation</topic><topic>Rats</topic><topic>Rats, Inbred Lew</topic><topic>Sciatic Nerve - anatomy & histology</topic><topic>Sciatic Nerve - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maeda, Tomoo</creatorcontrib><creatorcontrib>Mackinnon, Susan E.</creatorcontrib><creatorcontrib>Best, Timothy J.</creatorcontrib><creatorcontrib>Evans, Peter J.</creatorcontrib><creatorcontrib>Hunter, Daniel A.</creatorcontrib><creatorcontrib>Rajiv Midha, R.T.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maeda, Tomoo</au><au>Mackinnon, Susan E.</au><au>Best, Timothy J.</au><au>Evans, Peter J.</au><au>Hunter, Daniel A.</au><au>Rajiv Midha, R.T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regeneration across ‘stepping-stone’ nerve grafts</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1993-08-06</date><risdate>1993</risdate><volume>618</volume><issue>2</issue><spage>196</spage><epage>202</epage><pages>196-202</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The ability of small nerve segments interposed between synthetic conduits to increase the total nerve gap distance across which successful nerve regeneration would occur was studied. Fifty adult male Lewis rats were randomized into five groups. In Group I a segment of resected sciatic nerve was repaired by a nerve graft. Group II had alternating silicone tubing/nerve graft/silicone tubing replacement of the resected nerve segment (single stepping stone group). Group III had silicone tubing/nerve graft/silicone tubing/nerve graft/silicone tubing repair of the nerve deficit (double stepping stone). Group IV had a single long silicone conduit repair. Group V control underwent a sham operation. Nerve regeneration was evaluated using walking track pattern analysis, electrophysiologic assessment and histomorphological evaluation. ‘Stepping stone nerve grafts’ enhanced regeneration across nerve gaps in comparison to a single long conduit, but were inferior to a single long nerve graft. In the repair of long nerve gaps, the use of multiple short conduits with interposed short nerve segments could provide a source of trophic factors to enhance regeneration.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>8374752</pmid><doi>10.1016/0006-8993(93)91266-U</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Body Weight - physiology Conduit Electrophysiology Fundamental and applied biological sciences. Psychology Isolated neuron and nerve. Neuroglia Male Nerve Fibers, Myelinated - physiology Nerve graft Nerve regeneration Nerve Regeneration - physiology Neurotropism Peripheral nerve Peripheral Nerves - anatomy & histology Peripheral Nerves - physiology Peripheral Nerves - transplantation Rats Rats, Inbred Lew Sciatic Nerve - anatomy & histology Sciatic Nerve - physiology Vertebrates: nervous system and sense organs |
| title | Regeneration across ‘stepping-stone’ nerve grafts |
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