Identification of a Calcium-Inducible, Epidermal-Specific Regulatory Element in the 3'-Flanking Region of the Human Keratin 1 Gene

Previous studies have shown that the process of epidermal differentiation is profoundly influenced by the level of intracellular calcium within keratinocytes. In this study we have identified a 249-bp region, located 7.9 kb downstream from the promoter of the human keratin 1 (HK1) gene, that is able...

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Veröffentlicht in:	Journal of investigative dermatology 1993-10, Vol.101 (4), p.506-513
Hauptverfasser:	Rothnagel, Joseph A, Greenhalgh, David A, Gagne, Todd A, Longley, Mary A, Roop, Dennis R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Biological and medical sciences Breast - cytology Breast - enzymology Calcium - pharmacology Cells, Cultured Chloramphenicol O-Acetyltransferase - metabolism Chromosome Mapping differentiation Epidermis - physiology Epithelial Cells Epithelium - enzymology expression Fibroblasts - enzymology Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation - drug effects Genes, Regulator Humans keratinocyte Keratinocytes - enzymology Keratins - genetics Molecular and cellular biology Molecular genetics Molecular Sequence Data Promoter Regions, Genetic Simian virus 40 - genetics transcription Transfection
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