Linkage relationships of the gene for apolipoprotein CII with loci on chromosome 19
Two common restriction fragment length polymorphisms detected with cloned gene probes for apolipoprotein CII (apo CII) have been used to study the inheritance of the gene in families segregating for loci on chromosome 19. Lod scores for APOC2 with the gene for complement component 3 (C3) exclude clo...
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| Veröffentlicht in: | Human genetics 1985, Vol.69 (1), p.39-43 |
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| container_title | Human genetics |
| container_volume | 69 |
| creator | DONALD, J. A WALLIS, S. C WILLIAMSON, R HUMPHRIES, S. E KESSLING, A TIPPETT, P ROBSON, E. B BALL, S DAVIES, K. E SCAMBLER, P BERG, K HEIBERG, A |
| description | Two common restriction fragment length polymorphisms detected with cloned gene probes for apolipoprotein CII (apo CII) have been used to study the inheritance of the gene in families segregating for loci on chromosome 19. Lod scores for APOC2 with the gene for complement component 3 (C3) exclude close linkage and give a maximum at a male recombination fraction of 0.25-0.30. Lod scores for APOC2 and FHC, the gene causing familial hypercholesterolaemia, are negative in males and suggest the genes may not be linked. However, it appears that APOC2 may be closely linked to the blood group loci Lutheran (Lu) and Secretor (Se), and probably less closely linked to Lewis (Le). These data are consistent with the gene order: FHC---C3---(Lu, Se, APOC2) |
| doi_str_mv | 10.1007/BF00295527 |
| format | Article |
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A ; WALLIS, S. C ; WILLIAMSON, R ; HUMPHRIES, S. E ; KESSLING, A ; TIPPETT, P ; ROBSON, E. B ; BALL, S ; DAVIES, K. E ; SCAMBLER, P ; BERG, K ; HEIBERG, A</creator><creatorcontrib>DONALD, J. A ; WALLIS, S. C ; WILLIAMSON, R ; HUMPHRIES, S. E ; KESSLING, A ; TIPPETT, P ; ROBSON, E. B ; BALL, S ; DAVIES, K. E ; SCAMBLER, P ; BERG, K ; HEIBERG, A</creatorcontrib><description>Two common restriction fragment length polymorphisms detected with cloned gene probes for apolipoprotein CII (apo CII) have been used to study the inheritance of the gene in families segregating for loci on chromosome 19. Lod scores for APOC2 with the gene for complement component 3 (C3) exclude close linkage and give a maximum at a male recombination fraction of 0.25-0.30. Lod scores for APOC2 and FHC, the gene causing familial hypercholesterolaemia, are negative in males and suggest the genes may not be linked. 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Biological and molecular evolution ; Human ; Humans ; Hyperlipoproteinemia Type II - genetics ; Male ; Pedigree ; Polymorphism, Genetic</subject><ispartof>Human genetics, 1985, Vol.69 (1), p.39-43</ispartof><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-71702abf4f025d979e50857e421effaee5e91185cfd5937e8f1327f3d89e3f693</citedby><cites>FETCH-LOGICAL-c311t-71702abf4f025d979e50857e421effaee5e91185cfd5937e8f1327f3d89e3f693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8460038$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3855405$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DONALD, J. A</creatorcontrib><creatorcontrib>WALLIS, S. C</creatorcontrib><creatorcontrib>WILLIAMSON, R</creatorcontrib><creatorcontrib>HUMPHRIES, S. E</creatorcontrib><creatorcontrib>KESSLING, A</creatorcontrib><creatorcontrib>TIPPETT, P</creatorcontrib><creatorcontrib>ROBSON, E. B</creatorcontrib><creatorcontrib>BALL, S</creatorcontrib><creatorcontrib>DAVIES, K. E</creatorcontrib><creatorcontrib>SCAMBLER, P</creatorcontrib><creatorcontrib>BERG, K</creatorcontrib><creatorcontrib>HEIBERG, A</creatorcontrib><title>Linkage relationships of the gene for apolipoprotein CII with loci on chromosome 19</title><title>Human genetics</title><addtitle>Hum Genet</addtitle><description>Two common restriction fragment length polymorphisms detected with cloned gene probes for apolipoprotein CII (apo CII) have been used to study the inheritance of the gene in families segregating for loci on chromosome 19. Lod scores for APOC2 with the gene for complement component 3 (C3) exclude close linkage and give a maximum at a male recombination fraction of 0.25-0.30. Lod scores for APOC2 and FHC, the gene causing familial hypercholesterolaemia, are negative in males and suggest the genes may not be linked. However, it appears that APOC2 may be closely linked to the blood group loci Lutheran (Lu) and Secretor (Se), and probably less closely linked to Lewis (Le). These data are consistent with the gene order: FHC---C3---(Lu, Se, APOC2)</description><subject>Apolipoprotein C-II</subject><subject>Apolipoproteins C - genetics</subject><subject>Biological and medical sciences</subject><subject>Blood Group Antigens - genetics</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, 19-20 - ultrastructure</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Complement C3 - genetics</subject><subject>DNA, Recombinant</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Linkage</subject><subject>Genetic Markers</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Human</subject><subject>Humans</subject><subject>Hyperlipoproteinemia Type II - genetics</subject><subject>Male</subject><subject>Pedigree</subject><subject>Polymorphism, Genetic</subject><issn>0340-6717</issn><issn>1432-1203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMFLwzAYxYMoc04v3oUcxINQ_ZI0S3PU4XQw8KCeS9Z-WaNtU5MO8b-3Y2Oe3uH9eDx-hFwyuGMA6v5xDsC1lFwdkTFLBU8YB3FMxiBSSKaKqVNyFuMnAJOayxEZiUzKFOSYvC1d-2XWSAPWpne-jZXrIvWW9hXSNbZIrQ_UdL52ne-C79G1dLZY0B_XV7T2haO-pUUVfOOjb5AyfU5OrKkjXuxzQj7mT--zl2T5-ryYPSyTQjDWJ8Mt4GZlUwtcllpplJBJhSlnaK1BlKgZy2RhS6mFwswywZUVZaZR2KkWE3Kz2x1ufW8w9nnjYoF1bVr0m5grqVPJ2Ra83YFF8DEGtHkXXGPCb84g3xrM_w0O8NV-dbNqsDyge2VDf73vTSxMbYNpCxcPWJZOAUQm_gBxV3a9</recordid><startdate>1985</startdate><enddate>1985</enddate><creator>DONALD, J. A</creator><creator>WALLIS, S. C</creator><creator>WILLIAMSON, R</creator><creator>HUMPHRIES, S. E</creator><creator>KESSLING, A</creator><creator>TIPPETT, P</creator><creator>ROBSON, E. B</creator><creator>BALL, S</creator><creator>DAVIES, K. E</creator><creator>SCAMBLER, P</creator><creator>BERG, K</creator><creator>HEIBERG, A</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1985</creationdate><title>Linkage relationships of the gene for apolipoprotein CII with loci on chromosome 19</title><author>DONALD, J. A ; WALLIS, S. C ; WILLIAMSON, R ; HUMPHRIES, S. E ; KESSLING, A ; TIPPETT, P ; ROBSON, E. B ; BALL, S ; DAVIES, K. 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Biological and molecular evolution</topic><topic>Human</topic><topic>Humans</topic><topic>Hyperlipoproteinemia Type II - genetics</topic><topic>Male</topic><topic>Pedigree</topic><topic>Polymorphism, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DONALD, J. A</creatorcontrib><creatorcontrib>WALLIS, S. C</creatorcontrib><creatorcontrib>WILLIAMSON, R</creatorcontrib><creatorcontrib>HUMPHRIES, S. E</creatorcontrib><creatorcontrib>KESSLING, A</creatorcontrib><creatorcontrib>TIPPETT, P</creatorcontrib><creatorcontrib>ROBSON, E. B</creatorcontrib><creatorcontrib>BALL, S</creatorcontrib><creatorcontrib>DAVIES, K. E</creatorcontrib><creatorcontrib>SCAMBLER, P</creatorcontrib><creatorcontrib>BERG, K</creatorcontrib><creatorcontrib>HEIBERG, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DONALD, J. A</au><au>WALLIS, S. C</au><au>WILLIAMSON, R</au><au>HUMPHRIES, S. E</au><au>KESSLING, A</au><au>TIPPETT, P</au><au>ROBSON, E. B</au><au>BALL, S</au><au>DAVIES, K. E</au><au>SCAMBLER, P</au><au>BERG, K</au><au>HEIBERG, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Linkage relationships of the gene for apolipoprotein CII with loci on chromosome 19</atitle><jtitle>Human genetics</jtitle><addtitle>Hum Genet</addtitle><date>1985</date><risdate>1985</risdate><volume>69</volume><issue>1</issue><spage>39</spage><epage>43</epage><pages>39-43</pages><issn>0340-6717</issn><eissn>1432-1203</eissn><coden>HUGEDQ</coden><abstract>Two common restriction fragment length polymorphisms detected with cloned gene probes for apolipoprotein CII (apo CII) have been used to study the inheritance of the gene in families segregating for loci on chromosome 19. Lod scores for APOC2 with the gene for complement component 3 (C3) exclude close linkage and give a maximum at a male recombination fraction of 0.25-0.30. Lod scores for APOC2 and FHC, the gene causing familial hypercholesterolaemia, are negative in males and suggest the genes may not be linked. However, it appears that APOC2 may be closely linked to the blood group loci Lutheran (Lu) and Secretor (Se), and probably less closely linked to Lewis (Le). These data are consistent with the gene order: FHC---C3---(Lu, Se, APOC2)</abstract><cop>Heidelberg</cop><cop>Berlin</cop><cop>New York, NY</cop><pub>Springer</pub><pmid>3855405</pmid><doi>10.1007/BF00295527</doi><tpages>5</tpages></addata></record> |
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| subjects | Apolipoprotein C-II Apolipoproteins C - genetics Biological and medical sciences Blood Group Antigens - genetics Chromosome Mapping Chromosomes, Human, 19-20 - ultrastructure Classical genetics, quantitative genetics, hybrids Complement C3 - genetics DNA, Recombinant Female Fundamental and applied biological sciences. Psychology Genetic Linkage Genetic Markers Genetics of eukaryotes. Biological and molecular evolution Human Humans Hyperlipoproteinemia Type II - genetics Male Pedigree Polymorphism, Genetic |
| title | Linkage relationships of the gene for apolipoprotein CII with loci on chromosome 19 |
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