Vaccination strategies against intracellular microbes
Leishmaniasis, malaria, tuberculosis, leprosy, typhoid and listeriosis are infections diseases which, together, cause enormous public health problems throughout the world. The etiologic agents of these diseases, Leishmania ssp., Plasmodium ssp., Mycobacterium tuberculosis, Mycobacterium leprae, Salm...
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| Veröffentlicht in: | FEMS immunology and medical microbiology 1993-08, Vol.7 (2), p.95-103 |
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| container_title | FEMS immunology and medical microbiology |
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| creator | Hess, Jürgen Kaufmann, Stefan H.E. |
| description | Leishmaniasis, malaria, tuberculosis, leprosy, typhoid and listeriosis are infections diseases which, together, cause enormous public health problems throughout the world. The etiologic agents of these diseases, Leishmania ssp., Plasmodium ssp., Mycobacterium tuberculosis, Mycobacterium leprae, Salmonella typhi/S. paratyphi or Listeria monocytogenes, respectively, are endowed with the capacity to utilize the intracellular habitat of various host cells, including macrophages, erythrocytes and liver cells. This intracellular habitat effectively protects them from antibody-mediated defence mechanisms, so that T lymphocytes are required for acquisition of antimicrobial protection. Protective immunity is best induced by viable vaccines, whereas soluble proteins are generally insufficient. In this review we will focus on immunity to tuberculosis and on the use of viable recombinant vaccines as multivalent carrier systems for the vaccination against various intracellular microbial infections. We will discuss new strategies to improve N, bovis BC and S. typhimurium aroA super(-) by genetic engineering, in order to evoke optimum protection. |
| doi_str_mv | 10.1111/j.1574-695X.1993.tb00387.x |
| format | Article |
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Psychology</subject><subject>Humans</subject><subject>Microbiology</subject><subject>Mycobacterium bovis</subject><subject>Salmonella typhimurium</subject><subject>T lymphocyte</subject><subject>T-Lymphocytes - immunology</subject><subject>Tuberculosis</subject><subject>Tuberculosis - prevention & control</subject><subject>Typhoid</subject><subject>Typhoid Fever - prevention & control</subject><subject>Typhoid-Paratyphoid Vaccines - immunology</subject><subject>Vaccination</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><subject>Vaccines, Synthetic - immunology</subject><issn>0928-8244</issn><issn>1574-695X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkFFLwzAQx4Moc04_gjBEfGu9NGmbCD7IcDqY-DLEt3BNk5HRddp0uH17U1b2KuYlcP_f5S4_Qm4oxDSc-1VM05xHmUw_Yyoli9sCgIk83p2Q4TE6JUOQiYhEwvk5ufB-BQBcAgzIQHCgnCVDkn6g1q7G1m3qsW8bbM3SGT_GJbrat2NXh5o2VbWtsBmvnW42hfGX5Mxi5c1Vf4_IYvq8mLxG8_eX2eRpHmkm0zSi0mZYJoCABSRU6pIiY4blwK3JZAg417bkAqilZZmYUEHJBM1sYS2yEbk7PPvVbL63xrdq7Xy3DNZms_UqTyXnNBF_gjSTXAieBfDhAIZ_eN8Yq74at8Zmryiozq1aqU6g6gSqzq3q3apdaL7up2yLtSmPrb3MkN_2OXqNlW2w1s4fMS4ZT3MI2OMB-3GV2f9jATWdvcmU_QLF8Zai</recordid><startdate>199308</startdate><enddate>199308</enddate><creator>Hess, Jürgen</creator><creator>Kaufmann, Stefan H.E.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>199308</creationdate><title>Vaccination strategies against intracellular microbes</title><author>Hess, Jürgen ; Kaufmann, Stefan H.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3955-19f6ad20a0ab0219cd1a33e3704fe6920a44cfd4801f1dd2e20aa93816fbffa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Applied microbiology</topic><topic>BCG Vaccine - immunology</topic><topic>Biological and medical sciences</topic><topic>Fundamental and applied biological sciences. 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The etiologic agents of these diseases, Leishmania ssp., Plasmodium ssp., Mycobacterium tuberculosis, Mycobacterium leprae, Salmonella typhi/S. paratyphi or Listeria monocytogenes, respectively, are endowed with the capacity to utilize the intracellular habitat of various host cells, including macrophages, erythrocytes and liver cells. This intracellular habitat effectively protects them from antibody-mediated defence mechanisms, so that T lymphocytes are required for acquisition of antimicrobial protection. Protective immunity is best induced by viable vaccines, whereas soluble proteins are generally insufficient. In this review we will focus on immunity to tuberculosis and on the use of viable recombinant vaccines as multivalent carrier systems for the vaccination against various intracellular microbial infections. 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| identifier | ISSN: 0928-8244 |
| ispartof | FEMS immunology and medical microbiology, 1993-08, Vol.7 (2), p.95-103 |
| issn | 0928-8244 1574-695X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75944128 |
| source | Oxford Journals Open Access Collection; MEDLINE; Wiley Online Library All Journals; Oxford University Press Journals Digital Archive Legacy |
| subjects | Animals Applied microbiology BCG Vaccine - immunology Biological and medical sciences Fundamental and applied biological sciences. Psychology Humans Microbiology Mycobacterium bovis Salmonella typhimurium T lymphocyte T-Lymphocytes - immunology Tuberculosis Tuberculosis - prevention & control Typhoid Typhoid Fever - prevention & control Typhoid-Paratyphoid Vaccines - immunology Vaccination Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Synthetic - immunology |
| title | Vaccination strategies against intracellular microbes |
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