Altered topoisomerase I activity and recombination activating gene expression in a human leukemia cell line resistant to doxorubicin

We examined the expression of the genes encoding topoisomerases I and II and those associated with V(D)J [variable(diversity)joining] recombination in two human T-cell acute lymphoblastic leukemia (T.ALL) cell lines, CEM and CEM/DOX. In CEM/JDOX cells, which are resistant to doxorubicin, the topoiso...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical pharmacology 1993-09, Vol.46 (5), p.851-861
Hauptverfasser:	Riou, Jean-François, Grondard, Lucile, Petitgenet, Odile, Abitbol, Marc, Lavelle, François
Format:	Artikel
Sprache:	eng
Schlagworte:	Amsacrine - pharmacology Antineoplastic agents Biological and medical sciences Camptothecin - pharmacology Cell Line - drug effects Cell Line - enzymology Cell Nucleus - enzymology Cell Survival - drug effects DNA Nucleotidyltransferases - metabolism DNA Topoisomerases, Type I - genetics DNA Topoisomerases, Type I - metabolism DNA Topoisomerases, Type II - metabolism Drug Resistance Gene Expression Regulation General aspects Genes, RAG-1 Humans Leukemia-Lymphoma, Adult T-Cell - genetics Medical sciences Pharmacology. Drug treatments Recombination, Genetic Topoisomerase II Inhibitors Transcriptional Activation VDJ Recombinases
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!