Improving Effects of FG-7080, a Serotonin Reuptake Inhibitor, on Scopolamine-Induced Performance Deficits of Memory Tasks in Rats
A novel serotonin reuptake inhibitor, (-)trans 4-(4-fluorophenyl)-3-(4-methoxyphenoxy-methyl)piperidine hydrochloride (FG-7080), was investigated for its effects on scopolamine-induced impairments in memory tasks of rats. In the radial-arm maze task, FG-7080 (3 mg/kg, p.o.) improved the impaired per...
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| Veröffentlicht in: | Japanese Journal of Pharmacology 1993, Vol.62(2), pp.203-206 |
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| container_title | Japanese Journal of Pharmacology |
| container_volume | 62 |
| creator | Miura, Naoyoshi Nakata, Naoki Tanaka, Yoshiaki Hiraga, Yoshihiro Ikeda, Yugo Ohata, Hisayuki Iwasaki, Tsuneo |
| description | A novel serotonin reuptake inhibitor, (-)trans 4-(4-fluorophenyl)-3-(4-methoxyphenoxy-methyl)piperidine hydrochloride (FG-7080), was investigated for its effects on scopolamine-induced impairments in memory tasks of rats. In the radial-arm maze task, FG-7080 (3 mg/kg, p.o.) improved the impaired performance. FG-7080 (1 mg/kg, p.o.) administered before the acquisition trial reduced the acquisition deficits in the passive avoidance task. Thus, the compound showed improving effects in the appetitive and aversive memory tasks. These findings suggest that FG-7080 may ameliorate the cognitive impairments caused by the cholinergic dysfunction. |
| doi_str_mv | 10.1254/jjp.62.203 |
| format | Article |
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These findings suggest that FG-7080 may ameliorate the cognitive impairments caused by the cholinergic dysfunction.</description><subject>Animals</subject><subject>Avoidance Learning - drug effects</subject><subject>Learning and memory</subject><subject>Male</subject><subject>Memory - drug effects</subject><subject>Piperidines - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Scopolamine</subject><subject>Scopolamine - antagonists & inhibitors</subject><subject>Serotonin reuptake inhibitor</subject><subject>Serotonin Uptake Inhibitors - pharmacology</subject><issn>0021-5198</issn><issn>1347-3506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1v1DAQxSMEKkvhwh3JJ07N4o_YsY-o7ZaVikC0nC2vd9x1mtjBTir1yH-OV1m4cpnR6D39Rm-mqt4TvCaUN5-6blwLuqaYvahWhDVtzTgWL6sVxpTUnCj5unqTc1dGiUlzVp1J1hJO5Kr6vR3GFJ98eEDXzoGdMooObW7qFkt8gQy6gxSnGHxAP2AeJ_MIaBsOfuenmC5QDOjOxjH2ZvAB6m3Yzxb26DskF9NgggV0Bc5bv3C_whDTM7o3-TGjI9JM-W31ypk-w7tTP69-bq7vL7_Ut99utpefb-uOqWaqpSPgMNkz7nbKAXFWcCkwb1pMDBXKOemowIRK2gjL95aDBUIJ2B2XnAt2Xn1cuCXvrxnypAefLfS9CRDnrFuuGiIV-6-RCNmoRrXF-OFknHcD7PWY_GDSsz4dt-ibRS-it6aPoS9H0l2cUyhJtXWi6-LYa6IU0xgLiqkuCTQunzwWIRlnRBXQ1QLq8mQe4N8ikyZv-0IcD5koTrSgmi7lSPgr24NJGgL7A24UqKc</recordid><startdate>19930101</startdate><enddate>19930101</enddate><creator>Miura, Naoyoshi</creator><creator>Nakata, Naoki</creator><creator>Tanaka, Yoshiaki</creator><creator>Hiraga, Yoshihiro</creator><creator>Ikeda, Yugo</creator><creator>Ohata, Hisayuki</creator><creator>Iwasaki, Tsuneo</creator><general>The Japanese Pharmacological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19930101</creationdate><title>Improving Effects of FG-7080, a Serotonin Reuptake Inhibitor, on Scopolamine-Induced Performance Deficits of Memory Tasks in Rats</title><author>Miura, Naoyoshi ; 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| ispartof | The Japanese Journal of Pharmacology, 1993, Vol.62(2), pp.203-206 |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Avoidance Learning - drug effects Learning and memory Male Memory - drug effects Piperidines - pharmacology Rats Rats, Wistar Scopolamine Scopolamine - antagonists & inhibitors Serotonin reuptake inhibitor Serotonin Uptake Inhibitors - pharmacology |
| title | Improving Effects of FG-7080, a Serotonin Reuptake Inhibitor, on Scopolamine-Induced Performance Deficits of Memory Tasks in Rats |
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