Cytotoxic Sesquiterpenes from Nardostachys chinensis
Five cytostatic sesquiterpenes, desoxo-narchinol-A (1), nardosinone (2), debilon (3), nardosinonediol (4) and kanshone A (5), were isolated from the roots and rhizomes of Nardostachys chinensis (Valerianaceae). The steric structure of 1 was determined by nuclear Overhauser effects (NOEs) and the exc...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1993/06/15, Vol.41(6), pp.1183-1184 |
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| container_title | Chemical & pharmaceutical bulletin |
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| creator | ITOKAWA, Hideji MASUYAMA, Koichi MORITA, Hiroshi TAKEYA, Koichi |
| description | Five cytostatic sesquiterpenes, desoxo-narchinol-A (1), nardosinone (2), debilon (3), nardosinonediol (4) and kanshone A (5), were isolated from the roots and rhizomes of Nardostachys chinensis (Valerianaceae). The steric structure of 1 was determined by nuclear Overhauser effects (NOEs) and the exciton chirality method. All five showed cytotoxic activity against P-388 cells and the structure-activity relationship of 1 was also discussed. |
| doi_str_mv | 10.1248/cpb.41.1183 |
| format | Article |
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The steric structure of 1 was determined by nuclear Overhauser effects (NOEs) and the exciton chirality method. All five showed cytotoxic activity against P-388 cells and the structure-activity relationship of 1 was also discussed.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.41.1183</identifier><identifier>PMID: 8370115</identifier><identifier>CODEN: CPBTAL</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Animals ; Biological and medical sciences ; Cell Death - drug effects ; cytotoxic activity ; desoxo-narchinol-A ; General pharmacology ; Magnetic Resonance Spectroscopy ; Medical sciences ; Mice ; Nardostachys chinensis ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. 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Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plants, Medicinal - chemistry</topic><topic>sesquiterpene</topic><topic>Sesquiterpenes - chemistry</topic><topic>Sesquiterpenes - isolation & purification</topic><topic>Sesquiterpenes - pharmacology</topic><topic>Tumor Cells, Cultured</topic><topic>Valerianaceae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ITOKAWA, Hideji</creatorcontrib><creatorcontrib>MASUYAMA, Koichi</creatorcontrib><creatorcontrib>MORITA, Hiroshi</creatorcontrib><creatorcontrib>TAKEYA, Koichi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ITOKAWA, Hideji</au><au>MASUYAMA, Koichi</au><au>MORITA, Hiroshi</au><au>TAKEYA, Koichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytotoxic Sesquiterpenes from Nardostachys chinensis</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>1993</date><risdate>1993</risdate><volume>41</volume><issue>6</issue><spage>1183</spage><epage>1184</epage><pages>1183-1184</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><coden>CPBTAL</coden><abstract>Five cytostatic sesquiterpenes, desoxo-narchinol-A (1), nardosinone (2), debilon (3), nardosinonediol (4) and kanshone A (5), were isolated from the roots and rhizomes of Nardostachys chinensis (Valerianaceae). The steric structure of 1 was determined by nuclear Overhauser effects (NOEs) and the exciton chirality method. All five showed cytotoxic activity against P-388 cells and the structure-activity relationship of 1 was also discussed.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>8370115</pmid><doi>10.1248/cpb.41.1183</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Chemical and Pharmaceutical Bulletin, 1993/06/15, Vol.41(6), pp.1183-1184 |
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| language | eng |
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| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Biological and medical sciences Cell Death - drug effects cytotoxic activity desoxo-narchinol-A General pharmacology Magnetic Resonance Spectroscopy Medical sciences Mice Nardostachys chinensis Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry sesquiterpene Sesquiterpenes - chemistry Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology Tumor Cells, Cultured Valerianaceae |
| title | Cytotoxic Sesquiterpenes from Nardostachys chinensis |
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