Evidence for two DNA repair enzymes for 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in human cells

Two DNA repair enzymes for 8-hydroxyguanine (also known as 7,8-dihydro-8-oxoguanine; OH8Gua, oxo8Gua) have been identified in human HeLa cell nuclear extract. One is OH8Gua-glycosylase and the other is OH8Gua-endonuclease that lacks OH8Gua-glycosylase activity. They were separated by heparin-Sepharo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 1993-09, Vol.268 (26), p.19416-19421
Hauptverfasser:	BESSHO, T, TANO, K, KASAI, H, OHTSUKA, E, NISHIMURA, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological and medical sciences Cell Nucleus - enzymology Chromatography, Affinity Chromatography, High Pressure Liquid DNA Repair DNA-Formamidopyrimidine Glycosylase Fundamental and applied biological sciences. Psychology Guanine - analogs & derivatives Guanine - metabolism HeLa Cells Humans Molecular and cellular biology Molecular genetics Molecular Sequence Data Mutagenesis. Repair N-Glycosyl Hydrolases - isolation & purification N-Glycosyl Hydrolases - metabolism Oligodeoxyribonucleotides Substrate Specificity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!