Portal endotoxin and cytokine responses during abdominal aortic surgery
Interleukin-6 (IL-6) is a major marker of tissue injury. Surgery induces a systemic IL-6 response related to the magnitude of the operation. An exaggerated IL-6 response is associated with the development of major complications after aortic aneurysm repair. Endotoxemia is a potent stimulus for cytok...
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| Veröffentlicht in: | The American journal of surgery 1993-09, Vol.166 (3), p.248-251 |
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| creator | Baigrie, Robert J. Lamont, Peter M. Whiting, Sarah Morris, Peter J. |
| description | Interleukin-6 (IL-6) is a major marker of tissue injury. Surgery induces a systemic IL-6 response related to the magnitude of the operation. An exaggerated IL-6 response is associated with the development of major complications after aortic aneurysm repair. Endotoxemia is a potent stimulus for cytokine release and may occur during aortic surgery. This study attempted to examine whether the observed IL-6 response during abdominal aortic surgery is related to the development of portal endotoxemia.
Serial samples of inferior mesenteric and systemic venous blood were obtained before, during, and after aortic cross-clamping in eight patients undergoing elective aortic aneurysm surgery.
Portal endotoxemia was detected in only five ofthe eight patients during the surgery, and there was no correlation with the IL-6 response. Both portal and systemic IL-6 levels rose during the course of surgery, but, by the time of abdominal wound closure, the mean portal IL-6 levels were eight times higher than the systemic IL-6 levels.
These results suggest that the portal circulationdraining the colon is a major source of the previously observed systemic IL-6 response to aortic surgery. The IL-6 response is not clearly related to portal endotoxemia but may reflect occult cellular injury in the colon occurring during surgery. |
| doi_str_mv | 10.1016/S0002-9610(05)80967-5 |
| format | Article |
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Serial samples of inferior mesenteric and systemic venous blood were obtained before, during, and after aortic cross-clamping in eight patients undergoing elective aortic aneurysm surgery.
Portal endotoxemia was detected in only five ofthe eight patients during the surgery, and there was no correlation with the IL-6 response. Both portal and systemic IL-6 levels rose during the course of surgery, but, by the time of abdominal wound closure, the mean portal IL-6 levels were eight times higher than the systemic IL-6 levels.
These results suggest that the portal circulationdraining the colon is a major source of the previously observed systemic IL-6 response to aortic surgery. The IL-6 response is not clearly related to portal endotoxemia but may reflect occult cellular injury in the colon occurring during surgery.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/S0002-9610(05)80967-5</identifier><identifier>PMID: 8368435</identifier><identifier>CODEN: AJSUAB</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Abdomen ; Aged ; Aorta ; Aorta, Abdominal - surgery ; Aortic aneurysms ; Biological and medical sciences ; Colon ; Complications ; Constriction ; Cytokines ; Cytokines - blood ; Endotoxemia ; Endotoxins ; Endotoxins - blood ; Humans ; Interleukin 6 ; Interleukin-6 - blood ; Interleukins ; Medical sciences ; Middle Aged ; Portal System ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels ; Wound healing</subject><ispartof>The American journal of surgery, 1993-09, Vol.166 (3), p.248-251</ispartof><rights>1993 Reed Publishing USA</rights><rights>1993 INIST-CNRS</rights><rights>1993. Reed Publishing USA</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-f8b6a8791c46d5dfa2e11738782398342583523f18055bfde620f3dc9d79f90a3</citedby><cites>FETCH-LOGICAL-c512t-f8b6a8791c46d5dfa2e11738782398342583523f18055bfde620f3dc9d79f90a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2847458018?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994,64384,64386,64388,72240</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4918989$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8368435$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baigrie, Robert J.</creatorcontrib><creatorcontrib>Lamont, Peter M.</creatorcontrib><creatorcontrib>Whiting, Sarah</creatorcontrib><creatorcontrib>Morris, Peter J.</creatorcontrib><title>Portal endotoxin and cytokine responses during abdominal aortic surgery</title><title>The American journal of surgery</title><addtitle>Am J Surg</addtitle><description>Interleukin-6 (IL-6) is a major marker of tissue injury. Surgery induces a systemic IL-6 response related to the magnitude of the operation. An exaggerated IL-6 response is associated with the development of major complications after aortic aneurysm repair. Endotoxemia is a potent stimulus for cytokine release and may occur during aortic surgery. This study attempted to examine whether the observed IL-6 response during abdominal aortic surgery is related to the development of portal endotoxemia.
Serial samples of inferior mesenteric and systemic venous blood were obtained before, during, and after aortic cross-clamping in eight patients undergoing elective aortic aneurysm surgery.
Portal endotoxemia was detected in only five ofthe eight patients during the surgery, and there was no correlation with the IL-6 response. Both portal and systemic IL-6 levels rose during the course of surgery, but, by the time of abdominal wound closure, the mean portal IL-6 levels were eight times higher than the systemic IL-6 levels.
These results suggest that the portal circulationdraining the colon is a major source of the previously observed systemic IL-6 response to aortic surgery. The IL-6 response is not clearly related to portal endotoxemia but may reflect occult cellular injury in the colon occurring during surgery.</description><subject>Abdomen</subject><subject>Aged</subject><subject>Aorta</subject><subject>Aorta, Abdominal - surgery</subject><subject>Aortic aneurysms</subject><subject>Biological and medical sciences</subject><subject>Colon</subject><subject>Complications</subject><subject>Constriction</subject><subject>Cytokines</subject><subject>Cytokines - blood</subject><subject>Endotoxemia</subject><subject>Endotoxins</subject><subject>Endotoxins - blood</subject><subject>Humans</subject><subject>Interleukin 6</subject><subject>Interleukin-6 - blood</subject><subject>Interleukins</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Portal System</subject><subject>Surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</subject><subject>Wound healing</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkNFKHDEUhkNR7LrtIwgDirQXY5PJZObkqhSpqyBUaHsdssmJRGeTNZkp7ts3usteeGNuDuF8_-HnI-SE0QtGWfftN6W0qWXH6BcqvgKVXV-LD2TGoJc1A-AHZLZHPpLjnB_Kl7GWH5Ej4B20XMzI4i6mUQ8VBhvH-OxDpYOtzGaMjz5glTCvY8iYKzslH-4rvbRx5UNJ6BL0pspTuse0-UQOnR4yft7NOfl79fPP5XV9-2txc_njtjaCNWPtYNnpUpCZtrPCOt0gYz2HHhougbeNAC4a7hhQIZbOYtdQx62RtpdOUs3n5Hx7d53i04R5VCufDQ6DDhinrHohOfDy5uT0DfgQp1SKZ9VA27cCKINCiS1lUsw5oVPr5Fc6bRSj6kWzetWsXhwqKtSrZiVK7mR3fVqu0O5TO69lf7bb62z04JIOxuc91koGEmTBvm8xLMr-eUwqG4_BoPUJzahs9O8U-Q9epZgr</recordid><startdate>19930901</startdate><enddate>19930901</enddate><creator>Baigrie, Robert J.</creator><creator>Lamont, Peter M.</creator><creator>Whiting, Sarah</creator><creator>Morris, Peter J.</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>19930901</creationdate><title>Portal endotoxin and cytokine responses during abdominal aortic surgery</title><author>Baigrie, Robert J. ; Lamont, Peter M. ; Whiting, Sarah ; Morris, Peter J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-f8b6a8791c46d5dfa2e11738782398342583523f18055bfde620f3dc9d79f90a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Abdomen</topic><topic>Aged</topic><topic>Aorta</topic><topic>Aorta, Abdominal - surgery</topic><topic>Aortic aneurysms</topic><topic>Biological and medical sciences</topic><topic>Colon</topic><topic>Complications</topic><topic>Constriction</topic><topic>Cytokines</topic><topic>Cytokines - blood</topic><topic>Endotoxemia</topic><topic>Endotoxins</topic><topic>Endotoxins - blood</topic><topic>Humans</topic><topic>Interleukin 6</topic><topic>Interleukin-6 - blood</topic><topic>Interleukins</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Portal System</topic><topic>Surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baigrie, Robert J.</creatorcontrib><creatorcontrib>Lamont, Peter M.</creatorcontrib><creatorcontrib>Whiting, Sarah</creatorcontrib><creatorcontrib>Morris, Peter J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baigrie, Robert J.</au><au>Lamont, Peter M.</au><au>Whiting, Sarah</au><au>Morris, Peter J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Portal endotoxin and cytokine responses during abdominal aortic surgery</atitle><jtitle>The American journal of surgery</jtitle><addtitle>Am J Surg</addtitle><date>1993-09-01</date><risdate>1993</risdate><volume>166</volume><issue>3</issue><spage>248</spage><epage>251</epage><pages>248-251</pages><issn>0002-9610</issn><eissn>1879-1883</eissn><coden>AJSUAB</coden><abstract>Interleukin-6 (IL-6) is a major marker of tissue injury. Surgery induces a systemic IL-6 response related to the magnitude of the operation. An exaggerated IL-6 response is associated with the development of major complications after aortic aneurysm repair. Endotoxemia is a potent stimulus for cytokine release and may occur during aortic surgery. This study attempted to examine whether the observed IL-6 response during abdominal aortic surgery is related to the development of portal endotoxemia.
Serial samples of inferior mesenteric and systemic venous blood were obtained before, during, and after aortic cross-clamping in eight patients undergoing elective aortic aneurysm surgery.
Portal endotoxemia was detected in only five ofthe eight patients during the surgery, and there was no correlation with the IL-6 response. Both portal and systemic IL-6 levels rose during the course of surgery, but, by the time of abdominal wound closure, the mean portal IL-6 levels were eight times higher than the systemic IL-6 levels.
These results suggest that the portal circulationdraining the colon is a major source of the previously observed systemic IL-6 response to aortic surgery. The IL-6 response is not clearly related to portal endotoxemia but may reflect occult cellular injury in the colon occurring during surgery.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8368435</pmid><doi>10.1016/S0002-9610(05)80967-5</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0002-9610 |
| ispartof | The American journal of surgery, 1993-09, Vol.166 (3), p.248-251 |
| issn | 0002-9610 1879-1883 |
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| subjects | Abdomen Aged Aorta Aorta, Abdominal - surgery Aortic aneurysms Biological and medical sciences Colon Complications Constriction Cytokines Cytokines - blood Endotoxemia Endotoxins Endotoxins - blood Humans Interleukin 6 Interleukin-6 - blood Interleukins Medical sciences Middle Aged Portal System Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels Wound healing |
| title | Portal endotoxin and cytokine responses during abdominal aortic surgery |
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