Effect of Benidipine Hydrochloride (KW-3049), on Cerebral Ischemia Induced by Bilateral Occlusion of the Common Carotid Arteries in Rats

The effect of benidipine on experimental cerebral ischemia was investigated in rats subjected to occlusion of the bilateral common carotid arteries. Benidipine (30 μg/kg, i.p.) improved neurological symptoms such as ataxia, convulsion and loss of righting reflex, and prolonged survival time after oc...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 1993/05/15, Vol.16(5), pp.475-479
Hauptverfasser:	SHIRAKURA, Shiro, KARASAWA, Akira, KUBO, Kazuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals Behavior, Animal - drug effects benidipine Biological and medical sciences Brain - pathology Brain Chemistry - drug effects Brain Ischemia - drug therapy Brain Ischemia - pathology Ca2+-antagonist Calcium Channel Blockers - therapeutic use Carotid Artery, Common - physiology cerebral ischemia Dihydropyridines - therapeutic use Lactates - metabolism Lactic Acid Male Medical sciences Neuropharmacology Neuroprotective agent Nicardipine - therapeutic use Nifedipine - therapeutic use occlusion Pharmacology. Drug treatments Phosphocreatine - metabolism Potassium - metabolism Rats Rats, Wistar Sodium - metabolism Verapamil - therapeutic use
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