Disposition kinetics of ML-1035 sulfoxide enantiomers and the prochiral sulfide in rats

ML‐1035, 4‐amino‐5‐chloro‐2‐[2‐(methylsulfinyl)ethoxy]‐N‐[2‐(diethylamino)ethyl]benzamide, is a sulfoxide compound and a racemic gastroprokinetic agent with a chiral center at the sulfur atom. We have investigated the disposition kinetics of (R)‐ML‐1035 sulfoxide (R) and (S)‐ML‐1035 sulfoxide (S) af...

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Veröffentlicht in:	Chirality (New York, N.Y.) N.Y.), 1993, Vol.5 (6), p.428-435
Hauptverfasser:	Kuo, Be-Sheng, Poole, James C., Mandagere, Arun K., Hwang, Kin-Kai
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antiemetics - administration & dosage Antiemetics - chemistry Antiemetics - pharmacokinetics benzamides Biological and medical sciences chiral sulfoxidation Chromatography, High Pressure Liquid Digestive system enantiomeric pharmacokinetics gastroprokinetic agents Injections, Intravenous Male Medical sciences Metoclopramide - administration & dosage Metoclopramide - analogs & derivatives Metoclopramide - chemistry Metoclopramide - pharmacokinetics Pharmacology. Drug treatments prochirality Rats Rats, Sprague-Dawley Stereoisomerism
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