Stereospecific actions of the inhalation anesthetic isoflurane at the GABAA receptor complex

The inhalation anesthetic isoflurane stereoselectively modulates ligand binding to the GABAA receptor complex. The (+)-isomer of isoflurane was more potent and efficacious than the (-)-isomer in enhancing [3H]flunitrazepam binding to benzodiazepine receptors. For example, concentration effect curves...

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Veröffentlicht in:	Brain research 1993-06, Vol.615 (1), p.101-106
Hauptverfasser:	MOODY, E. J, HARRIS, B. D, SKOLNICK, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetics. Neuromuscular blocking agents Animals Biological and medical sciences Bridged Bicyclo Compounds - metabolism Bridged Bicyclo Compounds, Heterocyclic Chlorides - metabolism Flunitrazepam - metabolism In Vitro Techniques Isoflurane - pharmacology Male Medical sciences Mice Neuropharmacology Pharmacology. Drug treatments Receptors, GABA-A - drug effects Stereoisomerism Sulfur Radioisotopes
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