Binding and cytotoxicity characteristics of the bispecific murine monoclonal antibody 2B1

Bispecific monoclonal antibodies (BsmAb) with specificity for tumor Ag and effector cell trigger molecules have been shown to redirect the cytotoxicity of several peripheral blood mononuclear cell populations against relevant tumor. The BsmAb, 2B1, binds to the extracellular domain of the c-erbB-2 g...

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Veröffentlicht in:	The Journal of immunology (1950) 1993-09, Vol.151 (5), p.2877-2886
Hauptverfasser:	Weiner, LM, Holmes, M, Richeson, A, Godwin, A, Adams, GP, Hsieh-Ma, ST, Ring, DB, Alpaugh, RK
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, immunoglobulins Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use Antibody Specificity Antigens, Neoplasm - immunology Biological and medical sciences Cytotoxicity, Immunologic Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunoglobulin G - immunology Killer Cells, Lymphokine-Activated - immunology Mice Molecular immunology Monoclonal antibodies Proto-Oncogene Proteins - genetics Proto-Oncogenes Receptor, ErbB-2 Receptors, IgG - analysis Tumor Cells, Cultured
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