Prenatal detection of neuroblastoma : a ten-year experience from the Dana-Farber cancer institute and children's hospital
To assess the relative frequency of, the clinical and pathological correlates in, and the prognosis of the subset of infants with neuroblastoma who were identified initially by prenatal ultrasonography. Retrospective review of all patients with neuroblastoma evaluated between 1982 and 1992. Large, u...
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| Veröffentlicht in: | Pediatrics (Evanston) 1993-09, Vol.92 (3), p.358-364 |
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| container_title | Pediatrics (Evanston) |
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| creator | HO, P. T. C ESTROFF, J. A KOZAKEWICH, H SHAMBERGER, R. C LILLEHEI, C. W GRIER, H. E DILLER, L |
| description | To assess the relative frequency of, the clinical and pathological correlates in, and the prognosis of the subset of infants with neuroblastoma who were identified initially by prenatal ultrasonography.
Retrospective review of all patients with neuroblastoma evaluated between 1982 and 1992.
Large, urban, tertiary care children's hospital in Boston, Massachusetts.
Eleven infants with neuroblastoma initially detected with prenatal sonograms were identified.
Nine patients had adrenal tumors; two had thoracic paraspinal tumors. Typical diagnostic evidence for neuroblastoma including a palpable abdominal mass and elevations in urinary catecholamines were not commonly seen postnatally. These patients had multiple favorable prognostic indicators including low stage of disease (10/11), favorable biological markers including cellular DNA content (5/5) and N-myc oncogene copy number (5/5), and histopathology suggestive for neuroblastoma in situ (7/11). All patients were treated by surgical resection. One patient exhibited progression of disease postoperatively, but demonstrated a complete clinical response to multiagent chemotherapy. Overall survival in our population was excellent with no deaths seen at a mean follow-up of 37 months (range 3 to 120 months).
Patients with neuroblastoma identified by prenatal ultrasonography generally, although not exclusively, follow a clinically favorable course in which surgical resection is curative. Chemotherapy is not indicated unless substantial progression of disease occurs. |
| doi_str_mv | 10.1542/peds.92.3.358 |
| format | Article |
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Retrospective review of all patients with neuroblastoma evaluated between 1982 and 1992.
Large, urban, tertiary care children's hospital in Boston, Massachusetts.
Eleven infants with neuroblastoma initially detected with prenatal sonograms were identified.
Nine patients had adrenal tumors; two had thoracic paraspinal tumors. Typical diagnostic evidence for neuroblastoma including a palpable abdominal mass and elevations in urinary catecholamines were not commonly seen postnatally. These patients had multiple favorable prognostic indicators including low stage of disease (10/11), favorable biological markers including cellular DNA content (5/5) and N-myc oncogene copy number (5/5), and histopathology suggestive for neuroblastoma in situ (7/11). All patients were treated by surgical resection. One patient exhibited progression of disease postoperatively, but demonstrated a complete clinical response to multiagent chemotherapy. Overall survival in our population was excellent with no deaths seen at a mean follow-up of 37 months (range 3 to 120 months).
Patients with neuroblastoma identified by prenatal ultrasonography generally, although not exclusively, follow a clinically favorable course in which surgical resection is curative. Chemotherapy is not indicated unless substantial progression of disease occurs.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.92.3.358</identifier><identifier>PMID: 8361790</identifier><identifier>CODEN: PEDIAU</identifier><language>eng</language><publisher>Elk Grove Village, IL: American Academy of Pediatrics</publisher><subject>Adrenal Gland Neoplasms - congenital ; Adrenal Gland Neoplasms - diagnostic imaging ; Adrenal Gland Neoplasms - epidemiology ; Babies ; Biological and medical sciences ; Boston - epidemiology ; Cancer ; Diagnosis ; Female ; Fetal Diseases - diagnostic imaging ; Fetal Diseases - epidemiology ; Follow-Up Studies ; Gynecology. Andrology. Obstetrics ; Humans ; Infant, Newborn ; Management. Prenatal diagnosis ; Medical sciences ; Medical screening ; Methods ; Neuroblastoma ; Neuroblastoma - congenital ; Neuroblastoma - diagnostic imaging ; Neuroblastoma - epidemiology ; Pediatric tumors ; Pediatrics ; Pregnancy ; Pregnancy. Fetus. Placenta ; Prenatal diagnosis ; Prognosis ; Retrospective Studies ; Time Factors ; Tumors in children ; Ultrasonography, Prenatal</subject><ispartof>Pediatrics (Evanston), 1993-09, Vol.92 (3), p.358-364</ispartof><rights>1994 INIST-CNRS</rights><rights>COPYRIGHT 1993 American Academy of Pediatrics</rights><rights>Copyright American Academy of Pediatrics Sep 1993</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c296t-93539a662d6ce6dc2d4f14be654bcf71f177576c9b592f0ac4d8a7ee6b8413123</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3754375$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8361790$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HO, P. T. C</creatorcontrib><creatorcontrib>ESTROFF, J. A</creatorcontrib><creatorcontrib>KOZAKEWICH, H</creatorcontrib><creatorcontrib>SHAMBERGER, R. C</creatorcontrib><creatorcontrib>LILLEHEI, C. W</creatorcontrib><creatorcontrib>GRIER, H. E</creatorcontrib><creatorcontrib>DILLER, L</creatorcontrib><title>Prenatal detection of neuroblastoma : a ten-year experience from the Dana-Farber cancer institute and children's hospital</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>To assess the relative frequency of, the clinical and pathological correlates in, and the prognosis of the subset of infants with neuroblastoma who were identified initially by prenatal ultrasonography.
Retrospective review of all patients with neuroblastoma evaluated between 1982 and 1992.
Large, urban, tertiary care children's hospital in Boston, Massachusetts.
Eleven infants with neuroblastoma initially detected with prenatal sonograms were identified.
Nine patients had adrenal tumors; two had thoracic paraspinal tumors. Typical diagnostic evidence for neuroblastoma including a palpable abdominal mass and elevations in urinary catecholamines were not commonly seen postnatally. These patients had multiple favorable prognostic indicators including low stage of disease (10/11), favorable biological markers including cellular DNA content (5/5) and N-myc oncogene copy number (5/5), and histopathology suggestive for neuroblastoma in situ (7/11). All patients were treated by surgical resection. One patient exhibited progression of disease postoperatively, but demonstrated a complete clinical response to multiagent chemotherapy. Overall survival in our population was excellent with no deaths seen at a mean follow-up of 37 months (range 3 to 120 months).
Patients with neuroblastoma identified by prenatal ultrasonography generally, although not exclusively, follow a clinically favorable course in which surgical resection is curative. Chemotherapy is not indicated unless substantial progression of disease occurs.</description><subject>Adrenal Gland Neoplasms - congenital</subject><subject>Adrenal Gland Neoplasms - diagnostic imaging</subject><subject>Adrenal Gland Neoplasms - epidemiology</subject><subject>Babies</subject><subject>Biological and medical sciences</subject><subject>Boston - epidemiology</subject><subject>Cancer</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Fetal Diseases - diagnostic imaging</subject><subject>Fetal Diseases - epidemiology</subject><subject>Follow-Up Studies</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Management. Prenatal diagnosis</subject><subject>Medical sciences</subject><subject>Medical screening</subject><subject>Methods</subject><subject>Neuroblastoma</subject><subject>Neuroblastoma - congenital</subject><subject>Neuroblastoma - diagnostic imaging</subject><subject>Neuroblastoma - epidemiology</subject><subject>Pediatric tumors</subject><subject>Pediatrics</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Prenatal diagnosis</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Time Factors</subject><subject>Tumors in children</subject><subject>Ultrasonography, Prenatal</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc2LFDEQxYMo67h69CgEEb3YY767s7dldFVYWA96Dul09U4v6aRN0rDz35thhj14KOrwftR71EPoLSVbKgX7ssCQt5pt-ZbL7hnaUKK7RrBWPkcbQjhtBCHyJXqV8wMhRMiWXaCLjivaarJBh18Jgi3W4wEKuDLFgOOIA6wp9t7mEmeLr7DFBUJzAJswPC6QJggO8JjijMse8FcbbHNjUw8JO1ulhKeQy1TWAtiGAbv95Ifq9CnjfczLVA1foxej9RnenPcl-nPz7ffuR3N79_3n7vq2cUyr0mguubZKsUE5UINjgxip6EFJ0buxpSNtW9kqp3up2UisE0NnWwDVd4Jyyvgl-ni6u6T4d4VczDxlB97bAHHNppVHC8Ur-P4_8CGuKdRshrGOc6K6rkKfT9C99WCm4GIo8Fhc9B7uwdTkuztzTQXXQnSi4s0JdynmnGA0S5pmmw6GEnOszxzrM5oZbmp9lX93zrD2MwxP9Lmvqn846zY768dUnz3lJ4y3UtTh_wA58aLf</recordid><startdate>199309</startdate><enddate>199309</enddate><creator>HO, P. T. C</creator><creator>ESTROFF, J. A</creator><creator>KOZAKEWICH, H</creator><creator>SHAMBERGER, R. C</creator><creator>LILLEHEI, C. W</creator><creator>GRIER, H. E</creator><creator>DILLER, L</creator><general>American Academy of Pediatrics</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>199309</creationdate><title>Prenatal detection of neuroblastoma : a ten-year experience from the Dana-Farber cancer institute and children's hospital</title><author>HO, P. T. C ; ESTROFF, J. A ; KOZAKEWICH, H ; SHAMBERGER, R. C ; LILLEHEI, C. W ; GRIER, H. E ; DILLER, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c296t-93539a662d6ce6dc2d4f14be654bcf71f177576c9b592f0ac4d8a7ee6b8413123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adrenal Gland Neoplasms - congenital</topic><topic>Adrenal Gland Neoplasms - diagnostic imaging</topic><topic>Adrenal Gland Neoplasms - epidemiology</topic><topic>Babies</topic><topic>Biological and medical sciences</topic><topic>Boston - epidemiology</topic><topic>Cancer</topic><topic>Diagnosis</topic><topic>Female</topic><topic>Fetal Diseases - diagnostic imaging</topic><topic>Fetal Diseases - epidemiology</topic><topic>Follow-Up Studies</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Management. Prenatal diagnosis</topic><topic>Medical sciences</topic><topic>Medical screening</topic><topic>Methods</topic><topic>Neuroblastoma</topic><topic>Neuroblastoma - congenital</topic><topic>Neuroblastoma - diagnostic imaging</topic><topic>Neuroblastoma - epidemiology</topic><topic>Pediatric tumors</topic><topic>Pediatrics</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Prenatal diagnosis</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Time Factors</topic><topic>Tumors in children</topic><topic>Ultrasonography, Prenatal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HO, P. T. C</creatorcontrib><creatorcontrib>ESTROFF, J. A</creatorcontrib><creatorcontrib>KOZAKEWICH, H</creatorcontrib><creatorcontrib>SHAMBERGER, R. C</creatorcontrib><creatorcontrib>LILLEHEI, C. W</creatorcontrib><creatorcontrib>GRIER, H. E</creatorcontrib><creatorcontrib>DILLER, L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HO, P. T. C</au><au>ESTROFF, J. A</au><au>KOZAKEWICH, H</au><au>SHAMBERGER, R. C</au><au>LILLEHEI, C. W</au><au>GRIER, H. E</au><au>DILLER, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prenatal detection of neuroblastoma : a ten-year experience from the Dana-Farber cancer institute and children's hospital</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>1993-09</date><risdate>1993</risdate><volume>92</volume><issue>3</issue><spage>358</spage><epage>364</epage><pages>358-364</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><coden>PEDIAU</coden><abstract>To assess the relative frequency of, the clinical and pathological correlates in, and the prognosis of the subset of infants with neuroblastoma who were identified initially by prenatal ultrasonography.
Retrospective review of all patients with neuroblastoma evaluated between 1982 and 1992.
Large, urban, tertiary care children's hospital in Boston, Massachusetts.
Eleven infants with neuroblastoma initially detected with prenatal sonograms were identified.
Nine patients had adrenal tumors; two had thoracic paraspinal tumors. Typical diagnostic evidence for neuroblastoma including a palpable abdominal mass and elevations in urinary catecholamines were not commonly seen postnatally. These patients had multiple favorable prognostic indicators including low stage of disease (10/11), favorable biological markers including cellular DNA content (5/5) and N-myc oncogene copy number (5/5), and histopathology suggestive for neuroblastoma in situ (7/11). All patients were treated by surgical resection. One patient exhibited progression of disease postoperatively, but demonstrated a complete clinical response to multiagent chemotherapy. Overall survival in our population was excellent with no deaths seen at a mean follow-up of 37 months (range 3 to 120 months).
Patients with neuroblastoma identified by prenatal ultrasonography generally, although not exclusively, follow a clinically favorable course in which surgical resection is curative. Chemotherapy is not indicated unless substantial progression of disease occurs.</abstract><cop>Elk Grove Village, IL</cop><pub>American Academy of Pediatrics</pub><pmid>8361790</pmid><doi>10.1542/peds.92.3.358</doi><tpages>7</tpages></addata></record> |
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| ispartof | Pediatrics (Evanston), 1993-09, Vol.92 (3), p.358-364 |
| issn | 0031-4005 1098-4275 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adrenal Gland Neoplasms - congenital Adrenal Gland Neoplasms - diagnostic imaging Adrenal Gland Neoplasms - epidemiology Babies Biological and medical sciences Boston - epidemiology Cancer Diagnosis Female Fetal Diseases - diagnostic imaging Fetal Diseases - epidemiology Follow-Up Studies Gynecology. Andrology. Obstetrics Humans Infant, Newborn Management. Prenatal diagnosis Medical sciences Medical screening Methods Neuroblastoma Neuroblastoma - congenital Neuroblastoma - diagnostic imaging Neuroblastoma - epidemiology Pediatric tumors Pediatrics Pregnancy Pregnancy. Fetus. Placenta Prenatal diagnosis Prognosis Retrospective Studies Time Factors Tumors in children Ultrasonography, Prenatal |
| title | Prenatal detection of neuroblastoma : a ten-year experience from the Dana-Farber cancer institute and children's hospital |
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