REGIONAL DISTRIBUTION AND ELIMINATION KINETICS OF IMIPRAMINE IN RAT BRAIN
The elimination of imipramine (IMP) from the brain regions was investigated in rats after a single intraperitoneal administration. The levels of IMP (ng/g wet tissue) in the brain regions reached concentrations approximately 30-fold higher than the plasma level 0.5 h after the administration. Brain...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1984/11/25, Vol.32(11), pp.4678-4681 |
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| container_end_page | 4681 |
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| container_issue | 11 |
| container_start_page | 4678 |
| container_title | Chemical & pharmaceutical bulletin |
| container_volume | 32 |
| creator | Masada, Mikio Suzuki, Kazutoshi Kikuta, Sadao Yamashita, Shinji Nakanishi, Kunio Nadai, Tanekazu Igarashi, Yoshio Noguchi, Takuro |
| description | The elimination of imipramine (IMP) from the brain regions was investigated in rats after a single intraperitoneal administration. The levels of IMP (ng/g wet tissue) in the brain regions reached concentrations approximately 30-fold higher than the plasma level 0.5 h after the administration. Brain regions could be divided into two classes as to IMP elimination : IMP in the cerebellum, mid-brain and medulla, striatum, posterior cortex and frontal cortex was eliminated in a monoexponential manner the similar to the plasma level while the disappearance in the hypothalamus, thalamus, hippocampus and nucleus accumbens followed a biexponential profile. |
| doi_str_mv | 10.1248/cpb.32.4678 |
| format | Article |
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The levels of IMP (ng/g wet tissue) in the brain regions reached concentrations approximately 30-fold higher than the plasma level 0.5 h after the administration. Brain regions could be divided into two classes as to IMP elimination : IMP in the cerebellum, mid-brain and medulla, striatum, posterior cortex and frontal cortex was eliminated in a monoexponential manner the similar to the plasma level while the disappearance in the hypothalamus, thalamus, hippocampus and nucleus accumbens followed a biexponential profile.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.32.4678</identifier><identifier>PMID: 6532564</identifier><identifier>CODEN: CPBTAL</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Animals ; Biological and medical sciences ; Brain - metabolism ; Imipramine - metabolism ; intraperitoneal dose ; Kinetics ; Male ; Medical sciences ; Neuropharmacology ; Pharmacology. Drug treatments ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. 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Pharm. Bull.</addtitle><description>The elimination of imipramine (IMP) from the brain regions was investigated in rats after a single intraperitoneal administration. The levels of IMP (ng/g wet tissue) in the brain regions reached concentrations approximately 30-fold higher than the plasma level 0.5 h after the administration. Brain regions could be divided into two classes as to IMP elimination : IMP in the cerebellum, mid-brain and medulla, striatum, posterior cortex and frontal cortex was eliminated in a monoexponential manner the similar to the plasma level while the disappearance in the hypothalamus, thalamus, hippocampus and nucleus accumbens followed a biexponential profile.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Imipramine - metabolism</subject><subject>intraperitoneal dose</subject><subject>Kinetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Tissue Distribution</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtPwkAUhSdGg4iuXJt0YdyY4rynXRYoOBGLKWU9mQ5ThZSHHVj4722lwc29ufd8OSc5ANwj2EeYBi9mn_cJ7lMuggvQRYQKn2FMLkEXQhj6mHByDW6cW0OIGRSkAzqcEcw47QKZxhM5S6KpN5LzLJWDRVafXpSMvHgq32US_d1vMokzOZx7s7FXfz_SqJZiTyZeGmXeII1kcguuCl06e9fuHliM42z46k9nEzmMpr5hXBz8ghoO7RIVhjNKaSEEypchZIHJMUe5RqzQQjNEbc5JyLVmkFqLoA0Zt3pJSQ88nXz31e77aN1BbVbO2LLUW7s7OiVYSGgoUA0-n0BT7ZyrbKH21Wqjqx-FoGqKU3VximDVFFfTD63tMd_Y5Zltm6r1x1bXzuiyqPTWrNwZCygKWAhrbHzC1u6gP-1Z19VhZUrbRKKQBU0sQu1s8v-BL10puyW_CKyGvQ</recordid><startdate>19840101</startdate><enddate>19840101</enddate><creator>Masada, Mikio</creator><creator>Suzuki, Kazutoshi</creator><creator>Kikuta, Sadao</creator><creator>Yamashita, Shinji</creator><creator>Nakanishi, Kunio</creator><creator>Nadai, Tanekazu</creator><creator>Igarashi, Yoshio</creator><creator>Noguchi, Takuro</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19840101</creationdate><title>REGIONAL DISTRIBUTION AND ELIMINATION KINETICS OF IMIPRAMINE IN RAT BRAIN</title><author>Masada, Mikio ; Suzuki, Kazutoshi ; Kikuta, Sadao ; Yamashita, Shinji ; Nakanishi, Kunio ; Nadai, Tanekazu ; Igarashi, Yoshio ; Noguchi, Takuro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c567t-f4c60ed1fc65444f771bd9058cb261ba15fa7a514eb6396aa504ee10e956ead43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Imipramine - metabolism</topic><topic>intraperitoneal dose</topic><topic>Kinetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Masada, Mikio</creatorcontrib><creatorcontrib>Suzuki, Kazutoshi</creatorcontrib><creatorcontrib>Kikuta, Sadao</creatorcontrib><creatorcontrib>Yamashita, Shinji</creatorcontrib><creatorcontrib>Nakanishi, Kunio</creatorcontrib><creatorcontrib>Nadai, Tanekazu</creatorcontrib><creatorcontrib>Igarashi, Yoshio</creatorcontrib><creatorcontrib>Noguchi, Takuro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Masada, Mikio</au><au>Suzuki, Kazutoshi</au><au>Kikuta, Sadao</au><au>Yamashita, Shinji</au><au>Nakanishi, Kunio</au><au>Nadai, Tanekazu</au><au>Igarashi, Yoshio</au><au>Noguchi, Takuro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>REGIONAL DISTRIBUTION AND ELIMINATION KINETICS OF IMIPRAMINE IN RAT BRAIN</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>1984-01-01</date><risdate>1984</risdate><volume>32</volume><issue>11</issue><spage>4678</spage><epage>4681</epage><pages>4678-4681</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><coden>CPBTAL</coden><abstract>The elimination of imipramine (IMP) from the brain regions was investigated in rats after a single intraperitoneal administration. The levels of IMP (ng/g wet tissue) in the brain regions reached concentrations approximately 30-fold higher than the plasma level 0.5 h after the administration. Brain regions could be divided into two classes as to IMP elimination : IMP in the cerebellum, mid-brain and medulla, striatum, posterior cortex and frontal cortex was eliminated in a monoexponential manner the similar to the plasma level while the disappearance in the hypothalamus, thalamus, hippocampus and nucleus accumbens followed a biexponential profile.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>6532564</pmid><doi>10.1248/cpb.32.4678</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Chemical and Pharmaceutical Bulletin, 1984/11/25, Vol.32(11), pp.4678-4681 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Free Full-Text Journals in Chemistry |
| subjects | Animals Biological and medical sciences Brain - metabolism Imipramine - metabolism intraperitoneal dose Kinetics Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Inbred Strains Tissue Distribution |
| title | REGIONAL DISTRIBUTION AND ELIMINATION KINETICS OF IMIPRAMINE IN RAT BRAIN |
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