Effects of Pentoxyfilline and Heparin on Reperfusion Injury Island Skin Flaps in Rats Exposed to Tobacco

Background Ischemia-reperfusion injury is believed to be a major cause of transferred skin flap failure. Cigarette smoking is known to be associated with endogenous antioxidant depletion, hypercoagulability, and cutaneous vasoconstriction. This investigation was carried out to study possible effects...

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Veröffentlicht in:	The Journal of surgical research 2010-11, Vol.164 (1), p.139-145
Hauptverfasser:	Freitas, Frederico A.S., M.D., Ph.D, Piccinato, Carlos E., M.D., Ph.D, Cherri, Jesualdo, M.D., Ph.D, Marchesan, Werther G., M.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Addictive behaviors Adult and adolescent clinical studies Animals Anticoagulants - pharmacology Biological and medical sciences Dermatologic Surgical Procedures Drug Therapy, Combination Free Radical Scavengers - pharmacology General aspects heparin Heparin - pharmacology ischemia Male Malondialdehyde - blood Medical sciences Necrosis Oxidative Stress - drug effects Pentoxifylline - pharmacology pentoxyfilline Peroxidase - blood Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Rats Rats, Wistar reperfusion Reperfusion Injury - drug therapy Skin - blood supply Skin - drug effects Surgery Surgical Flaps - blood supply Surgical Flaps - pathology Tobacco Smoke Pollution - adverse effects Tobacco smoking tobacco, flaps Tobacco, tobacco smoking Toxicology Vasoconstriction - drug effects Vasoconstriction - physiology
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