Intrauterine Inflammation as a Risk Factor for Persistent Ductus Arteriosus Patency after Cyclooxygenase Inhibition in Extremely Low Birth Weight Infants
Objectives To test the hypothesis that intrauterine inflammation increases prostaglandin production and may be a risk factor for persistent ductus arteriosus after therapy with indomethacin, a nonselective cyclooxygenase inhibitor. Study design Indomethacin therapy was started after confirming ductu...
Gespeichert in:
Veröffentlicht in: | The Journal of pediatrics 2010-11, Vol.157 (5), p.745-750.e1 |
---|---|
Hauptverfasser: | , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 750.e1 |
---|---|
container_issue | 5 |
container_start_page | 745 |
container_title | The Journal of pediatrics |
container_volume | 157 |
creator | Kim, Eun Sun, MD Kim, Ee-Kyung, MD Choi, Chang Won, MD Kim, Han-Suk, MD Kim, Beyong Il, MD Choi, Jung-Hwan, MD Park, Joong Shin, MD Moon, Kyung Chul, MD |
description | Objectives To test the hypothesis that intrauterine inflammation increases prostaglandin production and may be a risk factor for persistent ductus arteriosus after therapy with indomethacin, a nonselective cyclooxygenase inhibitor. Study design Indomethacin therapy was started after confirming ductus arteriosus within 24 hours after birth in extremely low birth weight infants. After one cycle of therapy, infants with closed ductus were classified as responders, and those with patent ductus were classified as nonresponders. Multiple logistic regression analysis was used to determine important perinatal factors associated with persistent ductus arteriosus. Immunohistochemistry with cyclooxygenase antibodies and radioimmunoassay by 6-keto prostaglandin F1α kit were used to determine the relationship between intrauterine inflammation and ductal patency. Results Forty-one infants were responders, and 37 infants were nonresponders. Responders were frequently small for gestational age; nonresponders frequently had lower gestational age, respiratory distress syndrome, and intrauterine inflammation. By multiple logistic regression analysis, respiratory distress syndrome and intrauterine inflammation were more frequent in nonresponders. Cyclooxygenase-1 expression in the umbilical arteries and plasma 6-keto prostaglandin F1α levels were higher in nonresponders. Conclusions Respiratory distress syndrome and intrauterine inflammation were independent risk factors for persistent ductus arteriosus after indomethacin therapy in extremely low-birth weight infants. Intrauterine inflammation may have a negative influence on ductus arteriosus closure via increased cyclooxygenase-1 activity. |
doi_str_mv | 10.1016/j.jpeds.2010.05.020 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_759325181</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022347610004233</els_id><sourcerecordid>759325181</sourcerecordid><originalsourceid>FETCH-LOGICAL-c443t-ac9ef96ed91f8067706336d21dc13fea8bd624e15bceabb81ffa44a4f5668ee43</originalsourceid><addsrcrecordid>eNqFUstuFDEQHCEQCYEvQEK-IE672GPP6wBSWBJYaSUiHuJoeTztrDcz9uL2QOZT-Fs82QUkLhwsW-2q6lZVZ9lTRpeMsvLlbrnbQ4fLnKYKLZY0p_eyU0abalHWnN_PTinN8wUXVXmSPULcUUobQenD7CSnRVNz1pxmP9cuBjVGCNYBWTvTq2FQ0XpHFBJFPlq8IZdKRx-ISecKAlqM4CJ5O-o4IjkPM9ljel6p9KEnokwqkdWke-9vp2twCmftrW3tnbJ15OI2Bhign8jG_yBvbIhb8hXs9TbOQygX8XH2wKge4cnxPsu-XF58Xr1fbD68W6_ONwstBI8LpRswTQldw0xNy6qiJedll7NOM25A1W1X5gJY0WpQbVszY5QQSpiiLGsAwc-yFwfdffDfRsAoB4sa-l458CPKqmh4XrCaJSQ_IHXwiAGM3Ac7qDBJRuUcidzJu0jkHImkhUyRJNazo_7YDtD94fzOIAGeHwEKtepNUE5b_IvjvGJczEKvDjhIbny3ECRqm_yGzgbQUXbe_meQ1__wdW-dTS1vYALc-TG4ZLRkEnNJ5ad5e-blYWlvRJqC_wIrJsN2</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>759325181</pqid></control><display><type>article</type><title>Intrauterine Inflammation as a Risk Factor for Persistent Ductus Arteriosus Patency after Cyclooxygenase Inhibition in Extremely Low Birth Weight Infants</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Kim, Eun Sun, MD ; Kim, Ee-Kyung, MD ; Choi, Chang Won, MD ; Kim, Han-Suk, MD ; Kim, Beyong Il, MD ; Choi, Jung-Hwan, MD ; Park, Joong Shin, MD ; Moon, Kyung Chul, MD</creator><creatorcontrib>Kim, Eun Sun, MD ; Kim, Ee-Kyung, MD ; Choi, Chang Won, MD ; Kim, Han-Suk, MD ; Kim, Beyong Il, MD ; Choi, Jung-Hwan, MD ; Park, Joong Shin, MD ; Moon, Kyung Chul, MD</creatorcontrib><description>Objectives To test the hypothesis that intrauterine inflammation increases prostaglandin production and may be a risk factor for persistent ductus arteriosus after therapy with indomethacin, a nonselective cyclooxygenase inhibitor. Study design Indomethacin therapy was started after confirming ductus arteriosus within 24 hours after birth in extremely low birth weight infants. After one cycle of therapy, infants with closed ductus were classified as responders, and those with patent ductus were classified as nonresponders. Multiple logistic regression analysis was used to determine important perinatal factors associated with persistent ductus arteriosus. Immunohistochemistry with cyclooxygenase antibodies and radioimmunoassay by 6-keto prostaglandin F1α kit were used to determine the relationship between intrauterine inflammation and ductal patency. Results Forty-one infants were responders, and 37 infants were nonresponders. Responders were frequently small for gestational age; nonresponders frequently had lower gestational age, respiratory distress syndrome, and intrauterine inflammation. By multiple logistic regression analysis, respiratory distress syndrome and intrauterine inflammation were more frequent in nonresponders. Cyclooxygenase-1 expression in the umbilical arteries and plasma 6-keto prostaglandin F1α levels were higher in nonresponders. Conclusions Respiratory distress syndrome and intrauterine inflammation were independent risk factors for persistent ductus arteriosus after indomethacin therapy in extremely low-birth weight infants. Intrauterine inflammation may have a negative influence on ductus arteriosus closure via increased cyclooxygenase-1 activity.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/j.jpeds.2010.05.020</identifier><identifier>PMID: 20598319</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>Maryland Heights, MO: Mosby, Inc</publisher><subject>Biological and medical sciences ; Cardiology. Vascular system ; Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava ; Cyclooxygenase Inhibitors - therapeutic use ; Ductus Arteriosus, Patent - drug therapy ; Ductus Arteriosus, Patent - epidemiology ; Ductus Arteriosus, Patent - etiology ; Epidemiology ; Female ; Fetal Diseases ; General aspects ; Heart ; Humans ; Indomethacin - therapeutic use ; Infant, Extremely Low Birth Weight ; Infant, Newborn ; Inflammation - complications ; Male ; Medical sciences ; Pediatrics ; Pilot Projects ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk Factors ; Treatment Failure</subject><ispartof>The Journal of pediatrics, 2010-11, Vol.157 (5), p.745-750.e1</ispartof><rights>Mosby, Inc.</rights><rights>2010 Mosby, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Mosby, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-ac9ef96ed91f8067706336d21dc13fea8bd624e15bceabb81ffa44a4f5668ee43</citedby><cites>FETCH-LOGICAL-c443t-ac9ef96ed91f8067706336d21dc13fea8bd624e15bceabb81ffa44a4f5668ee43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpeds.2010.05.020$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23371340$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20598319$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Eun Sun, MD</creatorcontrib><creatorcontrib>Kim, Ee-Kyung, MD</creatorcontrib><creatorcontrib>Choi, Chang Won, MD</creatorcontrib><creatorcontrib>Kim, Han-Suk, MD</creatorcontrib><creatorcontrib>Kim, Beyong Il, MD</creatorcontrib><creatorcontrib>Choi, Jung-Hwan, MD</creatorcontrib><creatorcontrib>Park, Joong Shin, MD</creatorcontrib><creatorcontrib>Moon, Kyung Chul, MD</creatorcontrib><title>Intrauterine Inflammation as a Risk Factor for Persistent Ductus Arteriosus Patency after Cyclooxygenase Inhibition in Extremely Low Birth Weight Infants</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>Objectives To test the hypothesis that intrauterine inflammation increases prostaglandin production and may be a risk factor for persistent ductus arteriosus after therapy with indomethacin, a nonselective cyclooxygenase inhibitor. Study design Indomethacin therapy was started after confirming ductus arteriosus within 24 hours after birth in extremely low birth weight infants. After one cycle of therapy, infants with closed ductus were classified as responders, and those with patent ductus were classified as nonresponders. Multiple logistic regression analysis was used to determine important perinatal factors associated with persistent ductus arteriosus. Immunohistochemistry with cyclooxygenase antibodies and radioimmunoassay by 6-keto prostaglandin F1α kit were used to determine the relationship between intrauterine inflammation and ductal patency. Results Forty-one infants were responders, and 37 infants were nonresponders. Responders were frequently small for gestational age; nonresponders frequently had lower gestational age, respiratory distress syndrome, and intrauterine inflammation. By multiple logistic regression analysis, respiratory distress syndrome and intrauterine inflammation were more frequent in nonresponders. Cyclooxygenase-1 expression in the umbilical arteries and plasma 6-keto prostaglandin F1α levels were higher in nonresponders. Conclusions Respiratory distress syndrome and intrauterine inflammation were independent risk factors for persistent ductus arteriosus after indomethacin therapy in extremely low-birth weight infants. Intrauterine inflammation may have a negative influence on ductus arteriosus closure via increased cyclooxygenase-1 activity.</description><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava</subject><subject>Cyclooxygenase Inhibitors - therapeutic use</subject><subject>Ductus Arteriosus, Patent - drug therapy</subject><subject>Ductus Arteriosus, Patent - epidemiology</subject><subject>Ductus Arteriosus, Patent - etiology</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Fetal Diseases</subject><subject>General aspects</subject><subject>Heart</subject><subject>Humans</subject><subject>Indomethacin - therapeutic use</subject><subject>Infant, Extremely Low Birth Weight</subject><subject>Infant, Newborn</subject><subject>Inflammation - complications</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pediatrics</subject><subject>Pilot Projects</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Risk Factors</subject><subject>Treatment Failure</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUstuFDEQHCEQCYEvQEK-IE672GPP6wBSWBJYaSUiHuJoeTztrDcz9uL2QOZT-Fs82QUkLhwsW-2q6lZVZ9lTRpeMsvLlbrnbQ4fLnKYKLZY0p_eyU0abalHWnN_PTinN8wUXVXmSPULcUUobQenD7CSnRVNz1pxmP9cuBjVGCNYBWTvTq2FQ0XpHFBJFPlq8IZdKRx-ISecKAlqM4CJ5O-o4IjkPM9ljel6p9KEnokwqkdWke-9vp2twCmftrW3tnbJ15OI2Bhign8jG_yBvbIhb8hXs9TbOQygX8XH2wKge4cnxPsu-XF58Xr1fbD68W6_ONwstBI8LpRswTQldw0xNy6qiJedll7NOM25A1W1X5gJY0WpQbVszY5QQSpiiLGsAwc-yFwfdffDfRsAoB4sa-l458CPKqmh4XrCaJSQ_IHXwiAGM3Ac7qDBJRuUcidzJu0jkHImkhUyRJNazo_7YDtD94fzOIAGeHwEKtepNUE5b_IvjvGJczEKvDjhIbny3ECRqm_yGzgbQUXbe_meQ1__wdW-dTS1vYALc-TG4ZLRkEnNJ5ad5e-blYWlvRJqC_wIrJsN2</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>Kim, Eun Sun, MD</creator><creator>Kim, Ee-Kyung, MD</creator><creator>Choi, Chang Won, MD</creator><creator>Kim, Han-Suk, MD</creator><creator>Kim, Beyong Il, MD</creator><creator>Choi, Jung-Hwan, MD</creator><creator>Park, Joong Shin, MD</creator><creator>Moon, Kyung Chul, MD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20101101</creationdate><title>Intrauterine Inflammation as a Risk Factor for Persistent Ductus Arteriosus Patency after Cyclooxygenase Inhibition in Extremely Low Birth Weight Infants</title><author>Kim, Eun Sun, MD ; Kim, Ee-Kyung, MD ; Choi, Chang Won, MD ; Kim, Han-Suk, MD ; Kim, Beyong Il, MD ; Choi, Jung-Hwan, MD ; Park, Joong Shin, MD ; Moon, Kyung Chul, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-ac9ef96ed91f8067706336d21dc13fea8bd624e15bceabb81ffa44a4f5668ee43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava</topic><topic>Cyclooxygenase Inhibitors - therapeutic use</topic><topic>Ductus Arteriosus, Patent - drug therapy</topic><topic>Ductus Arteriosus, Patent - epidemiology</topic><topic>Ductus Arteriosus, Patent - etiology</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Fetal Diseases</topic><topic>General aspects</topic><topic>Heart</topic><topic>Humans</topic><topic>Indomethacin - therapeutic use</topic><topic>Infant, Extremely Low Birth Weight</topic><topic>Infant, Newborn</topic><topic>Inflammation - complications</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pediatrics</topic><topic>Pilot Projects</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Risk Factors</topic><topic>Treatment Failure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Eun Sun, MD</creatorcontrib><creatorcontrib>Kim, Ee-Kyung, MD</creatorcontrib><creatorcontrib>Choi, Chang Won, MD</creatorcontrib><creatorcontrib>Kim, Han-Suk, MD</creatorcontrib><creatorcontrib>Kim, Beyong Il, MD</creatorcontrib><creatorcontrib>Choi, Jung-Hwan, MD</creatorcontrib><creatorcontrib>Park, Joong Shin, MD</creatorcontrib><creatorcontrib>Moon, Kyung Chul, MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Eun Sun, MD</au><au>Kim, Ee-Kyung, MD</au><au>Choi, Chang Won, MD</au><au>Kim, Han-Suk, MD</au><au>Kim, Beyong Il, MD</au><au>Choi, Jung-Hwan, MD</au><au>Park, Joong Shin, MD</au><au>Moon, Kyung Chul, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intrauterine Inflammation as a Risk Factor for Persistent Ductus Arteriosus Patency after Cyclooxygenase Inhibition in Extremely Low Birth Weight Infants</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>2010-11-01</date><risdate>2010</risdate><volume>157</volume><issue>5</issue><spage>745</spage><epage>750.e1</epage><pages>745-750.e1</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>Objectives To test the hypothesis that intrauterine inflammation increases prostaglandin production and may be a risk factor for persistent ductus arteriosus after therapy with indomethacin, a nonselective cyclooxygenase inhibitor. Study design Indomethacin therapy was started after confirming ductus arteriosus within 24 hours after birth in extremely low birth weight infants. After one cycle of therapy, infants with closed ductus were classified as responders, and those with patent ductus were classified as nonresponders. Multiple logistic regression analysis was used to determine important perinatal factors associated with persistent ductus arteriosus. Immunohistochemistry with cyclooxygenase antibodies and radioimmunoassay by 6-keto prostaglandin F1α kit were used to determine the relationship between intrauterine inflammation and ductal patency. Results Forty-one infants were responders, and 37 infants were nonresponders. Responders were frequently small for gestational age; nonresponders frequently had lower gestational age, respiratory distress syndrome, and intrauterine inflammation. By multiple logistic regression analysis, respiratory distress syndrome and intrauterine inflammation were more frequent in nonresponders. Cyclooxygenase-1 expression in the umbilical arteries and plasma 6-keto prostaglandin F1α levels were higher in nonresponders. Conclusions Respiratory distress syndrome and intrauterine inflammation were independent risk factors for persistent ductus arteriosus after indomethacin therapy in extremely low-birth weight infants. Intrauterine inflammation may have a negative influence on ductus arteriosus closure via increased cyclooxygenase-1 activity.</abstract><cop>Maryland Heights, MO</cop><pub>Mosby, Inc</pub><pmid>20598319</pmid><doi>10.1016/j.jpeds.2010.05.020</doi><tpages>6</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0022-3476 |
ispartof | The Journal of pediatrics, 2010-11, Vol.157 (5), p.745-750.e1 |
issn | 0022-3476 1097-6833 |
language | eng |
recordid | cdi_proquest_miscellaneous_759325181 |
source | MEDLINE; Elsevier ScienceDirect Journals Complete |
subjects | Biological and medical sciences Cardiology. Vascular system Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava Cyclooxygenase Inhibitors - therapeutic use Ductus Arteriosus, Patent - drug therapy Ductus Arteriosus, Patent - epidemiology Ductus Arteriosus, Patent - etiology Epidemiology Female Fetal Diseases General aspects Heart Humans Indomethacin - therapeutic use Infant, Extremely Low Birth Weight Infant, Newborn Inflammation - complications Male Medical sciences Pediatrics Pilot Projects Public health. Hygiene Public health. Hygiene-occupational medicine Risk Factors Treatment Failure |
title | Intrauterine Inflammation as a Risk Factor for Persistent Ductus Arteriosus Patency after Cyclooxygenase Inhibition in Extremely Low Birth Weight Infants |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T18%3A13%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Intrauterine%20Inflammation%20as%20a%20Risk%20Factor%20for%20Persistent%20Ductus%20Arteriosus%20Patency%20after%20Cyclooxygenase%20Inhibition%20in%20Extremely%20Low%20Birth%20Weight%20Infants&rft.jtitle=The%20Journal%20of%20pediatrics&rft.au=Kim,%20Eun%20Sun,%20MD&rft.date=2010-11-01&rft.volume=157&rft.issue=5&rft.spage=745&rft.epage=750.e1&rft.pages=745-750.e1&rft.issn=0022-3476&rft.eissn=1097-6833&rft.coden=JOPDAB&rft_id=info:doi/10.1016/j.jpeds.2010.05.020&rft_dat=%3Cproquest_cross%3E759325181%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=759325181&rft_id=info:pmid/20598319&rft_els_id=S0022347610004233&rfr_iscdi=true |