Immunohistochemical expression of p16(INK4A) protein as a helpful marker of a subset of potentially malignant oral epithelial lesions: study on a series with long-term follow-up
To examine a group of lesions that progressed to oral squamous cell carcinoma (OSCC) to determine whether p16(INK4A) expression is an early finding during malignant transformation, and whether immunohistochemical evaluation of p16(INK4A) is an appropriate prognostic marker. Twenty cases of OSCC we...
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| Veröffentlicht in: | Histopathology 2010-10, Vol.57 (4), p.528-534 |
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| container_title | Histopathology |
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| creator | Montebugnoli, Lucio Cervellati, Fabio Cocchi, Roberto Farnedi, Anna Pennesi, Maria Gabriella Flamminio, Federica Foschini, Maria Pia |
| description | To examine a group of lesions that progressed to oral squamous cell carcinoma (OSCC) to determine whether p16(INK4A) expression is an early finding during malignant transformation, and whether immunohistochemical evaluation of p16(INK4A) is an appropriate prognostic marker.
Twenty cases of OSCC were investigated. All cases had had a biopsy on the same site as OSCC performed at least 1year before OSCC (range 1-11years; mean 3.15±3.1years). Twenty specimens from normal oral mucosa served as controls. p16(INK4A) expression was evaluated by immunohistochemical analysis and cases showing >5% of stained cells were defined as 'positive'. All 20 control cases were negative for p16(INK4A) . Oral lesions were p16(INK4A) -positive in nine cases and negative in 11. No significant relationship was found between p16(INK4A) positivity and the presence/absence of dysplasia. Among OSCC, nine tumours showed p16(INK4A) positivity and 11 showed negativity. A significant relationship (χ(2)=7.1; P |
| doi_str_mv | 10.1111/j.1365-2559.2010.03671.x |
| format | Article |
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Twenty cases of OSCC were investigated. All cases had had a biopsy on the same site as OSCC performed at least 1year before OSCC (range 1-11years; mean 3.15±3.1years). Twenty specimens from normal oral mucosa served as controls. p16(INK4A) expression was evaluated by immunohistochemical analysis and cases showing >5% of stained cells were defined as 'positive'. All 20 control cases were negative for p16(INK4A) . Oral lesions were p16(INK4A) -positive in nine cases and negative in 11. No significant relationship was found between p16(INK4A) positivity and the presence/absence of dysplasia. Among OSCC, nine tumours showed p16(INK4A) positivity and 11 showed negativity. A significant relationship (χ(2)=7.1; P<0.01) was found between the presence/absence of p16(INK4A) staining in OSCC and the presence/absence of p16(INK4A) staining in lesions preceding OSCC.
p16(INK4A) immunohistochemistry has a potential role in detecting a subset of p16(INK4A) -positive lesions with malignant potential.</description><identifier>EISSN: 1365-2559</identifier><identifier>DOI: 10.1111/j.1365-2559.2010.03671.x</identifier><identifier>PMID: 20955378</identifier><language>eng</language><publisher>England</publisher><subject>Aged ; Aged, 80 and over ; Biomarkers, Tumor - analysis ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - pathology ; Cyclin-Dependent Kinase Inhibitor p16 - biosynthesis ; Female ; Follow-Up Studies ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Mouth Neoplasms - metabolism ; Mouth Neoplasms - pathology ; Precancerous Conditions - metabolism ; Precancerous Conditions - pathology</subject><ispartof>Histopathology, 2010-10, Vol.57 (4), p.528-534</ispartof><rights>2010 Blackwell Publishing Limited.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20955378$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Montebugnoli, Lucio</creatorcontrib><creatorcontrib>Cervellati, Fabio</creatorcontrib><creatorcontrib>Cocchi, Roberto</creatorcontrib><creatorcontrib>Farnedi, Anna</creatorcontrib><creatorcontrib>Pennesi, Maria Gabriella</creatorcontrib><creatorcontrib>Flamminio, Federica</creatorcontrib><creatorcontrib>Foschini, Maria Pia</creatorcontrib><title>Immunohistochemical expression of p16(INK4A) protein as a helpful marker of a subset of potentially malignant oral epithelial lesions: study on a series with long-term follow-up</title><title>Histopathology</title><addtitle>Histopathology</addtitle><description>To examine a group of lesions that progressed to oral squamous cell carcinoma (OSCC) to determine whether p16(INK4A) expression is an early finding during malignant transformation, and whether immunohistochemical evaluation of p16(INK4A) is an appropriate prognostic marker.
Twenty cases of OSCC were investigated. All cases had had a biopsy on the same site as OSCC performed at least 1year before OSCC (range 1-11years; mean 3.15±3.1years). Twenty specimens from normal oral mucosa served as controls. p16(INK4A) expression was evaluated by immunohistochemical analysis and cases showing >5% of stained cells were defined as 'positive'. All 20 control cases were negative for p16(INK4A) . Oral lesions were p16(INK4A) -positive in nine cases and negative in 11. No significant relationship was found between p16(INK4A) positivity and the presence/absence of dysplasia. Among OSCC, nine tumours showed p16(INK4A) positivity and 11 showed negativity. A significant relationship (χ(2)=7.1; P<0.01) was found between the presence/absence of p16(INK4A) staining in OSCC and the presence/absence of p16(INK4A) staining in lesions preceding OSCC.
p16(INK4A) immunohistochemistry has a potential role in detecting a subset of p16(INK4A) -positive lesions with malignant potential.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cyclin-Dependent Kinase Inhibitor p16 - biosynthesis</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - metabolism</subject><subject>Mouth Neoplasms - pathology</subject><subject>Precancerous Conditions - metabolism</subject><subject>Precancerous Conditions - pathology</subject><issn>1365-2559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtOwzAQRS0kREvhF5B3wCLBduIkZldVPCoq2MC6spNJ6-LEIXbU9rP4Q1xesxlp7pk7mosQpiSmoW42MU0yHjHORcxImJIky2m8O0Ljf2GETp3bEELzhLETNGJEcJ7kxRh9zptmaO1aO2_LNTS6lAbDruvBOW1bbGvc0exq_vyUTq9x11sPusXSYYnXYLp6MLiR_Tv0B1JiNygH_nsrkK3X0ph9IIxetbINQn-w77QPy0HDBg5X3C12fqj2OBwMHtBrcHgbIGxsu4o89A2urTF2Gw3dGTqupXFw_tsn6O3-7nX2GC1eHuaz6SLqKOM-ohVQkRBSKVVRwkIUhKtUcZFLUkmVc66UKFMuGRR5KjORVUVZMF6rNKtSUSQTdPnjG57-GMD5ZaNdCcbIFuzgljkXCUt5KgJ58UsOqoFq2fU6ZLJf_qWcfAGQy4H4</recordid><startdate>201010</startdate><enddate>201010</enddate><creator>Montebugnoli, Lucio</creator><creator>Cervellati, Fabio</creator><creator>Cocchi, Roberto</creator><creator>Farnedi, Anna</creator><creator>Pennesi, Maria Gabriella</creator><creator>Flamminio, Federica</creator><creator>Foschini, Maria Pia</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201010</creationdate><title>Immunohistochemical expression of p16(INK4A) protein as a helpful marker of a subset of potentially malignant oral epithelial lesions: study on a series with long-term follow-up</title><author>Montebugnoli, Lucio ; Cervellati, Fabio ; Cocchi, Roberto ; Farnedi, Anna ; Pennesi, Maria Gabriella ; Flamminio, Federica ; Foschini, Maria Pia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p125t-1de19300dbbd10213605b4b597a0dab755bb9c45a2e874a696d8c825fb46d4983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Cyclin-Dependent Kinase Inhibitor p16 - biosynthesis</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - metabolism</topic><topic>Mouth Neoplasms - pathology</topic><topic>Precancerous Conditions - metabolism</topic><topic>Precancerous Conditions - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Montebugnoli, Lucio</creatorcontrib><creatorcontrib>Cervellati, Fabio</creatorcontrib><creatorcontrib>Cocchi, Roberto</creatorcontrib><creatorcontrib>Farnedi, Anna</creatorcontrib><creatorcontrib>Pennesi, Maria Gabriella</creatorcontrib><creatorcontrib>Flamminio, Federica</creatorcontrib><creatorcontrib>Foschini, Maria Pia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Histopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Montebugnoli, Lucio</au><au>Cervellati, Fabio</au><au>Cocchi, Roberto</au><au>Farnedi, Anna</au><au>Pennesi, Maria Gabriella</au><au>Flamminio, Federica</au><au>Foschini, Maria Pia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunohistochemical expression of p16(INK4A) protein as a helpful marker of a subset of potentially malignant oral epithelial lesions: study on a series with long-term follow-up</atitle><jtitle>Histopathology</jtitle><addtitle>Histopathology</addtitle><date>2010-10</date><risdate>2010</risdate><volume>57</volume><issue>4</issue><spage>528</spage><epage>534</epage><pages>528-534</pages><eissn>1365-2559</eissn><abstract>To examine a group of lesions that progressed to oral squamous cell carcinoma (OSCC) to determine whether p16(INK4A) expression is an early finding during malignant transformation, and whether immunohistochemical evaluation of p16(INK4A) is an appropriate prognostic marker.
Twenty cases of OSCC were investigated. All cases had had a biopsy on the same site as OSCC performed at least 1year before OSCC (range 1-11years; mean 3.15±3.1years). Twenty specimens from normal oral mucosa served as controls. p16(INK4A) expression was evaluated by immunohistochemical analysis and cases showing >5% of stained cells were defined as 'positive'. All 20 control cases were negative for p16(INK4A) . Oral lesions were p16(INK4A) -positive in nine cases and negative in 11. No significant relationship was found between p16(INK4A) positivity and the presence/absence of dysplasia. Among OSCC, nine tumours showed p16(INK4A) positivity and 11 showed negativity. A significant relationship (χ(2)=7.1; P<0.01) was found between the presence/absence of p16(INK4A) staining in OSCC and the presence/absence of p16(INK4A) staining in lesions preceding OSCC.
p16(INK4A) immunohistochemistry has a potential role in detecting a subset of p16(INK4A) -positive lesions with malignant potential.</abstract><cop>England</cop><pmid>20955378</pmid><doi>10.1111/j.1365-2559.2010.03671.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Biomarkers, Tumor - analysis Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cyclin-Dependent Kinase Inhibitor p16 - biosynthesis Female Follow-Up Studies Humans Immunohistochemistry Male Middle Aged Mouth Neoplasms - metabolism Mouth Neoplasms - pathology Precancerous Conditions - metabolism Precancerous Conditions - pathology |
| title | Immunohistochemical expression of p16(INK4A) protein as a helpful marker of a subset of potentially malignant oral epithelial lesions: study on a series with long-term follow-up |
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