Efficacy of bicozamycin in preventing traveler's diarrhea
Bicozamycin was compared with a placebo in a prospective, randomized, double-blind study of the prevention of acute diarrhea among 30 American travelers newly arrived in Guadalajara, Mexico. None of the 11 subjects given bicozamycin orally for 3 wk at a dosage of 500 mg four times a day developed di...
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| Veröffentlicht in: | Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 1985-02, Vol.88 (2), p.473-477 |
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| container_end_page | 477 |
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| container_issue | 2 |
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| container_title | Gastroenterology (New York, N.Y. 1943) |
| container_volume | 88 |
| creator | Ericsson, Charles D. Dupont, Herbert L. Galindo, Emma Mathewson, John J. Morgan, Donna R. Wood, Lindsey V. Mendiola, Jaime |
| description | Bicozamycin was compared with a placebo in a prospective, randomized, double-blind study of the prevention of acute diarrhea among 30 American travelers newly arrived in Guadalajara, Mexico. None of the 11 subjects given bicozamycin orally for 3 wk at a dosage of 500 mg four times a day developed diarrhea as compared with an incidence of 53% diarrhea (10 of 19 subjects) in the placebo group (p = 0.003). Bicozamycin was well tolerated. Studies of changes in predominant aerobic fecal flora among the 11 subjects treated with bicozamycin showed the appearance of only one highly resistant Citrobacter freundii at the end of 1 wk of therapy and only a total of six resistant isolates at the end of 3 wk. All resistant isolates failed to transfer this resistance to a recipient Escherichia coli. Bicozamycin seems to be well suited and safe as a prophylactic agent against traveler's diarrhea. |
| doi_str_mv | 10.1016/0016-5085(85)90509-8 |
| format | Article |
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None of the 11 subjects given bicozamycin orally for 3 wk at a dosage of 500 mg four times a day developed diarrhea as compared with an incidence of 53% diarrhea (10 of 19 subjects) in the placebo group (p = 0.003). Bicozamycin was well tolerated. Studies of changes in predominant aerobic fecal flora among the 11 subjects treated with bicozamycin showed the appearance of only one highly resistant Citrobacter freundii at the end of 1 wk of therapy and only a total of six resistant isolates at the end of 3 wk. All resistant isolates failed to transfer this resistance to a recipient Escherichia coli. 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None of the 11 subjects given bicozamycin orally for 3 wk at a dosage of 500 mg four times a day developed diarrhea as compared with an incidence of 53% diarrhea (10 of 19 subjects) in the placebo group (p = 0.003). Bicozamycin was well tolerated. Studies of changes in predominant aerobic fecal flora among the 11 subjects treated with bicozamycin showed the appearance of only one highly resistant Citrobacter freundii at the end of 1 wk of therapy and only a total of six resistant isolates at the end of 3 wk. All resistant isolates failed to transfer this resistance to a recipient Escherichia coli. Bicozamycin seems to be well suited and safe as a prophylactic agent against traveler's diarrhea.</description><subject>Acute Disease</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Bridged Bicyclo Compounds - therapeutic use</subject><subject>Bridged Bicyclo Compounds, Heterocyclic</subject><subject>Citrobacter freundii</subject><subject>Diarrhea - prevention & control</subject><subject>Double-Blind Method</subject><subject>Escherichia coli</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mexico</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Prospective Studies</subject><subject>Random Allocation</subject><subject>Travel</subject><issn>0016-5085</issn><issn>1528-0012</issn><issn>1528-0012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFqGzEQhkVJcR0nb9DCHkKSHjaRVtJKewmE4CQFQy_NWYylUauy3nWltcF9-sjx4mMCw8zh_2YYPkK-MnrDKKtvaW6lpFpea_m9oZI2pf5EpkxWusxZdUKmR-QLOU3pL6W04ZpNyIQ3teS8npJm7n2wYHdF74tlsP1_WO1s6Ipc64hb7IbQ_S6GCFtsMV6lwgWI8Q_CGfnsoU14Ps4ZeXmc_3p4Lhc_n3483C9KK7QaSsWc8vkl4QVyjtKp2qNS3INWqoYKvAQLdCmYQHRUAq9lzZUSaIE77fiMXB7urmP_b4NpMKuQLLYtdNhvklGy4RXT9EOQCdYwSVUGxQG0sU8pojfrGFYQd4ZRs1dr9t7M3pvJ9abW6Lz2bby_Wa7QHZdGlzm_GHNIFlofobMhHbGmkpXQMmN3BwyztG3AaJIN2Fl0IaIdjOvD-3-8AilKk-w</recordid><startdate>198502</startdate><enddate>198502</enddate><creator>Ericsson, Charles D.</creator><creator>Dupont, Herbert L.</creator><creator>Galindo, Emma</creator><creator>Mathewson, John J.</creator><creator>Morgan, Donna R.</creator><creator>Wood, Lindsey V.</creator><creator>Mendiola, Jaime</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>198502</creationdate><title>Efficacy of bicozamycin in preventing traveler's diarrhea</title><author>Ericsson, Charles D. ; Dupont, Herbert L. ; Galindo, Emma ; Mathewson, John J. ; Morgan, Donna R. ; Wood, Lindsey V. ; Mendiola, Jaime</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-71d7f5284f4e33e5d76fe773fa8776a2af5aca0b414eed05a36563774eca3d8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Acute Disease</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Bridged Bicyclo Compounds - therapeutic use</topic><topic>Bridged Bicyclo Compounds, Heterocyclic</topic><topic>Citrobacter freundii</topic><topic>Diarrhea - prevention & control</topic><topic>Double-Blind Method</topic><topic>Escherichia coli</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mexico</topic><topic>Middle Aged</topic><topic>Pharmacology. 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None of the 11 subjects given bicozamycin orally for 3 wk at a dosage of 500 mg four times a day developed diarrhea as compared with an incidence of 53% diarrhea (10 of 19 subjects) in the placebo group (p = 0.003). Bicozamycin was well tolerated. Studies of changes in predominant aerobic fecal flora among the 11 subjects treated with bicozamycin showed the appearance of only one highly resistant Citrobacter freundii at the end of 1 wk of therapy and only a total of six resistant isolates at the end of 3 wk. All resistant isolates failed to transfer this resistance to a recipient Escherichia coli. Bicozamycin seems to be well suited and safe as a prophylactic agent against traveler's diarrhea.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>3965336</pmid><doi>10.1016/0016-5085(85)90509-8</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE; Alma/SFX Local Collection |
| subjects | Acute Disease Adolescent Adult Aged Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Bridged Bicyclo Compounds - therapeutic use Bridged Bicyclo Compounds, Heterocyclic Citrobacter freundii Diarrhea - prevention & control Double-Blind Method Escherichia coli Female Humans Male Medical sciences Mexico Middle Aged Pharmacology. Drug treatments Prospective Studies Random Allocation Travel |
| title | Efficacy of bicozamycin in preventing traveler's diarrhea |
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