Allelic variation of serotonin transporter expression is associated with depression in Parkinson's disease

Idiopathic Parkinson's disease (PD) is a common neurodegenerative disorder with prominent motor symptoms. However, depression is common in PD, affecting about 40% of PD patients. Since there is extensive evidence of degeneration of serotonin (5HT) neurons and loss of the 5HT transporter (5HTT)...

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Veröffentlicht in:	Molecular psychiatry 2001-05, Vol.6 (3), p.350-352
Hauptverfasser:	MÖSSNER, R, HENNEBERG, A, SCHMITT, A, SYAGAILO, Y. V, GRÄSSLE, M, HENNIG, T, SIMANTOV, R, GERLACH, M, RIEDERER, P, LESCH, K. P
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amine oxidase (flavin-containing) Biological and medical sciences Carrier proteins Carrier Proteins - genetics Complications and side effects Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Depression - genetics Depression, Mental Female Gene Expression Gene polymorphism Genes Genetic aspects Genetic Variation Genotype & phenotype Humans Male Medical sciences Membrane Glycoproteins - genetics Membrane Transport Proteins Mental depression Monoamine Oxidase - genetics Movement disorders Nerve Tissue Proteins Neurodegeneration Neurodegenerative diseases Neurology Parkinson Disease - genetics Parkinson Disease - psychology Parkinson's disease Physiological aspects Polymorphism Polymorphism, Genetic Promoter Regions, Genetic - genetics Psychiatry Risk factors Serotonin Serotonin Plasma Membrane Transport Proteins Serotonin transporter
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