Morgue mediates apoptosis in the Drosophila melanogaster retina by promoting degradation of DIAP1

Inhibitor of apoptosis proteins (IAPs) provide a critical barrier to inappropriate apoptotic cell death through direct binding and inhibition of caspases. We demonstrate that degradation of IAPs is an important mechanism for the initiation of apoptosis in vivo. Drosophila Morgue, a ubiquitin conjuga...

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Veröffentlicht in:	Nature cell biology 2002-06, Vol.4 (6), p.425-431
Hauptverfasser:	Cagan, Ross, Hays, Rebecca, Wickline, Laura
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Apoptosis Apoptosis - physiology Biomedical and Life Sciences Cancer Research Cell Biology Cells, Cultured Chromosome Mapping Chromosomes Conserved Sequence Degradation Developmental Biology Drosophila Drosophila melanogaster Drosophila Proteins - genetics Drosophila Proteins - metabolism Eye Proteins - genetics Eye Proteins - metabolism Gene Expression Regulation, Developmental Gene Expression Regulation, Enzymologic Genetic aspects In Vitro Techniques Inhibitor of Apoptosis Proteins Life Sciences Ligases - genetics Molecular Sequence Data Mortality Neuropeptides - metabolism Peptides - metabolism Photoreceptor Cells, Invertebrate - cytology Photoreceptor Cells, Invertebrate - embryology Photoreceptor Cells, Invertebrate - enzymology Physiological aspects Proteins Retina Retina - cytology Retina - embryology Retina - enzymology Stem Cells Ubiquitin - metabolism Ubiquitin-Conjugating Enzymes Ubiquitin-proteasome system
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