Morgue mediates apoptosis in the Drosophila melanogaster retina by promoting degradation of DIAP1
Inhibitor of apoptosis proteins (IAPs) provide a critical barrier to inappropriate apoptotic cell death through direct binding and inhibition of caspases. We demonstrate that degradation of IAPs is an important mechanism for the initiation of apoptosis in vivo. Drosophila Morgue, a ubiquitin conjuga...
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| Veröffentlicht in: | Nature cell biology 2002-06, Vol.4 (6), p.425-431 |
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| creator | Hays, Rebecca Wickline, Laura Cagan, Ross |
| description | Inhibitor of apoptosis proteins (IAPs) provide a critical barrier to inappropriate apoptotic cell death through direct binding and inhibition of caspases. We demonstrate that degradation of IAPs is an important mechanism for the initiation of apoptosis
in vivo. Drosophila
Morgue, a ubiquitin conjugase-related protein, promotes DIAP1 down-regulation in the developing retina to permit selective programmed cell death. Morgue complexes with DIAP1
in vitro
and mediates DIAP1 degradation in a manner dependent on the Morgue UBC domain. Reaper (Rpr) and Grim, but not Hid, also promote the degradation of DIAP1
in vivo
, suggesting that these proteins promote cell death through different mechanisms. |
| doi_str_mv | 10.1038/ncb794 |
| format | Article |
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in vivo. Drosophila
Morgue, a ubiquitin conjugase-related protein, promotes DIAP1 down-regulation in the developing retina to permit selective programmed cell death. Morgue complexes with DIAP1
in vitro
and mediates DIAP1 degradation in a manner dependent on the Morgue UBC domain. Reaper (Rpr) and Grim, but not Hid, also promote the degradation of DIAP1
in vivo
, suggesting that these proteins promote cell death through different mechanisms.</description><identifier>ISSN: 1465-7392</identifier><identifier>ISSN: 1476-4679</identifier><identifier>EISSN: 1476-4679</identifier><identifier>DOI: 10.1038/ncb794</identifier><identifier>PMID: 12021768</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Amino Acid Sequence ; Animals ; Apoptosis ; Apoptosis - physiology ; Biomedical and Life Sciences ; Cancer Research ; Cell Biology ; Cells, Cultured ; Chromosome Mapping ; Chromosomes ; Conserved Sequence ; Degradation ; Developmental Biology ; Drosophila ; Drosophila melanogaster ; Drosophila Proteins - genetics ; Drosophila Proteins - metabolism ; Eye Proteins - genetics ; Eye Proteins - metabolism ; Gene Expression Regulation, Developmental ; Gene Expression Regulation, Enzymologic ; Genetic aspects ; In Vitro Techniques ; Inhibitor of Apoptosis Proteins ; Life Sciences ; Ligases - genetics ; Molecular Sequence Data ; Mortality ; Neuropeptides - metabolism ; Peptides - metabolism ; Photoreceptor Cells, Invertebrate - cytology ; Photoreceptor Cells, Invertebrate - embryology ; Photoreceptor Cells, Invertebrate - enzymology ; Physiological aspects ; Proteins ; Retina ; Retina - cytology ; Retina - embryology ; Retina - enzymology ; Stem Cells ; Ubiquitin - metabolism ; Ubiquitin-Conjugating Enzymes ; Ubiquitin-proteasome system</subject><ispartof>Nature cell biology, 2002-06, Vol.4 (6), p.425-431</ispartof><rights>Springer Nature Limited 2002</rights><rights>COPYRIGHT 2002 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jun 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-cec05b2302c3a1e2b515895738e43dc653ceefb7356ed773b018feb50e0114853</citedby><cites>FETCH-LOGICAL-c536t-cec05b2302c3a1e2b515895738e43dc653ceefb7356ed773b018feb50e0114853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ncb794$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ncb794$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12021768$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hays, Rebecca</creatorcontrib><creatorcontrib>Wickline, Laura</creatorcontrib><creatorcontrib>Cagan, Ross</creatorcontrib><title>Morgue mediates apoptosis in the Drosophila melanogaster retina by promoting degradation of DIAP1</title><title>Nature cell biology</title><addtitle>Nat Cell Biol</addtitle><addtitle>Nat Cell Biol</addtitle><description>Inhibitor of apoptosis proteins (IAPs) provide a critical barrier to inappropriate apoptotic cell death through direct binding and inhibition of caspases. We demonstrate that degradation of IAPs is an important mechanism for the initiation of apoptosis
in vivo. Drosophila
Morgue, a ubiquitin conjugase-related protein, promotes DIAP1 down-regulation in the developing retina to permit selective programmed cell death. Morgue complexes with DIAP1
in vitro
and mediates DIAP1 degradation in a manner dependent on the Morgue UBC domain. Reaper (Rpr) and Grim, but not Hid, also promote the degradation of DIAP1
in vivo
, suggesting that these proteins promote cell death through different mechanisms.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Apoptosis - physiology</subject><subject>Biomedical and Life Sciences</subject><subject>Cancer Research</subject><subject>Cell Biology</subject><subject>Cells, Cultured</subject><subject>Chromosome Mapping</subject><subject>Chromosomes</subject><subject>Conserved Sequence</subject><subject>Degradation</subject><subject>Developmental Biology</subject><subject>Drosophila</subject><subject>Drosophila melanogaster</subject><subject>Drosophila Proteins - genetics</subject><subject>Drosophila Proteins - metabolism</subject><subject>Eye Proteins - genetics</subject><subject>Eye Proteins - metabolism</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Gene Expression Regulation, Enzymologic</subject><subject>Genetic aspects</subject><subject>In Vitro Techniques</subject><subject>Inhibitor of Apoptosis Proteins</subject><subject>Life Sciences</subject><subject>Ligases - genetics</subject><subject>Molecular Sequence Data</subject><subject>Mortality</subject><subject>Neuropeptides - metabolism</subject><subject>Peptides - metabolism</subject><subject>Photoreceptor Cells, Invertebrate - cytology</subject><subject>Photoreceptor Cells, Invertebrate - embryology</subject><subject>Photoreceptor Cells, Invertebrate - enzymology</subject><subject>Physiological aspects</subject><subject>Proteins</subject><subject>Retina</subject><subject>Retina - cytology</subject><subject>Retina - embryology</subject><subject>Retina - enzymology</subject><subject>Stem Cells</subject><subject>Ubiquitin - metabolism</subject><subject>Ubiquitin-Conjugating Enzymes</subject><subject>Ubiquitin-proteasome system</subject><issn>1465-7392</issn><issn>1476-4679</issn><issn>1476-4679</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkstu1TAQhiMEoqXAIyCLBYhFiq-xvTxqCxypCMRlHTnOJHWV2MF2pPbt6-oc6ahdFHnh2zejf2b-qnpL8CnBTH32tpOaP6uOCZdNzRupn9-fG1FLpulR9Sqla4wJ51i-rI4IxZTIRh1X5nuI4wpoht6ZDAmZJSw5JJeQ8yhfATqPIYXlyk2mQJPxYTQpQ0QRsvMGdbdoiWEO5TKiHsZoepNd8CgM6Hy7-UleVy8GMyV4s99Pqr9fLv6cfasvf3zdnm0uaytYk2sLFouOMkwtMwRoJ4hQWkimgLPeNoJZgKGTTDTQS8k6TNQAncCACeFKsJPq4y5vkfNvhZTb2SULU5EMYU2tFJoRjbUs5IenydIaKSj_L0gUF5oTXcD3j8DrsEZfym0ppUxj1dACne6g0UzQOj-EHI0tq4fZ2eBhcOV9QxSjSoqGlYBPDwIKk-Emj2ZNqd3-_vWQ3Uu1ZVwpwtAu0c0m3rYEt_cOaXcOKeC7vdS1K0M_YHtLHPqYypcfIR5qeZTqDp3HwQA</recordid><startdate>20020601</startdate><enddate>20020601</enddate><creator>Hays, Rebecca</creator><creator>Wickline, Laura</creator><creator>Cagan, Ross</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7SS</scope><scope>7X8</scope></search><sort><creationdate>20020601</creationdate><title>Morgue mediates apoptosis in the Drosophila melanogaster retina by promoting degradation of DIAP1</title><author>Hays, Rebecca ; Wickline, Laura ; Cagan, Ross</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-cec05b2302c3a1e2b515895738e43dc653ceefb7356ed773b018feb50e0114853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Apoptosis - 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embryology</topic><topic>Photoreceptor Cells, Invertebrate - enzymology</topic><topic>Physiological aspects</topic><topic>Proteins</topic><topic>Retina</topic><topic>Retina - cytology</topic><topic>Retina - embryology</topic><topic>Retina - enzymology</topic><topic>Stem Cells</topic><topic>Ubiquitin - metabolism</topic><topic>Ubiquitin-Conjugating Enzymes</topic><topic>Ubiquitin-proteasome system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hays, Rebecca</creatorcontrib><creatorcontrib>Wickline, Laura</creatorcontrib><creatorcontrib>Cagan, Ross</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medicine (ProQuest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest Biological Science Journals</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>MEDLINE - Academic</collection><jtitle>Nature cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hays, Rebecca</au><au>Wickline, Laura</au><au>Cagan, Ross</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Morgue mediates apoptosis in the Drosophila melanogaster retina by promoting degradation of DIAP1</atitle><jtitle>Nature cell biology</jtitle><stitle>Nat Cell Biol</stitle><addtitle>Nat Cell Biol</addtitle><date>2002-06-01</date><risdate>2002</risdate><volume>4</volume><issue>6</issue><spage>425</spage><epage>431</epage><pages>425-431</pages><issn>1465-7392</issn><issn>1476-4679</issn><eissn>1476-4679</eissn><abstract>Inhibitor of apoptosis proteins (IAPs) provide a critical barrier to inappropriate apoptotic cell death through direct binding and inhibition of caspases. We demonstrate that degradation of IAPs is an important mechanism for the initiation of apoptosis
in vivo. Drosophila
Morgue, a ubiquitin conjugase-related protein, promotes DIAP1 down-regulation in the developing retina to permit selective programmed cell death. Morgue complexes with DIAP1
in vitro
and mediates DIAP1 degradation in a manner dependent on the Morgue UBC domain. Reaper (Rpr) and Grim, but not Hid, also promote the degradation of DIAP1
in vivo
, suggesting that these proteins promote cell death through different mechanisms.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>12021768</pmid><doi>10.1038/ncb794</doi><tpages>7</tpages></addata></record> |
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| subjects | Amino Acid Sequence Animals Apoptosis Apoptosis - physiology Biomedical and Life Sciences Cancer Research Cell Biology Cells, Cultured Chromosome Mapping Chromosomes Conserved Sequence Degradation Developmental Biology Drosophila Drosophila melanogaster Drosophila Proteins - genetics Drosophila Proteins - metabolism Eye Proteins - genetics Eye Proteins - metabolism Gene Expression Regulation, Developmental Gene Expression Regulation, Enzymologic Genetic aspects In Vitro Techniques Inhibitor of Apoptosis Proteins Life Sciences Ligases - genetics Molecular Sequence Data Mortality Neuropeptides - metabolism Peptides - metabolism Photoreceptor Cells, Invertebrate - cytology Photoreceptor Cells, Invertebrate - embryology Photoreceptor Cells, Invertebrate - enzymology Physiological aspects Proteins Retina Retina - cytology Retina - embryology Retina - enzymology Stem Cells Ubiquitin - metabolism Ubiquitin-Conjugating Enzymes Ubiquitin-proteasome system |
| title | Morgue mediates apoptosis in the Drosophila melanogaster retina by promoting degradation of DIAP1 |
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