Behavioral Changes and [123I]IBZM Equilibrium SPECT Measurement of Amphetamine-Induced Dopamine Release in Rhesus Monkeys Exposed to Subchronic Amphetamine

Previously we have shown that twelve weeks of repeated low-dose d-amphetamine (AMPH) exposure in rhesus monkeys induces a long-lasting enhancement of behavioral responses to acute low-dose challenge. The present study was designed to investigate the behavioral and neurochemical consequences of a six...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2000-01, Vol.22 (1), p.4-13
Hauptverfasser:	Castner, Stacy A, Al-Tikriti, Mohammed S, Baldwin, Ronald M, Seibyl, John P, Innis, Robert B, Goldman-Rakic, Patricia S
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphetamines Animal model Animals Behavioral sensitization Benzamides - pharmacokinetics Biological and medical sciences Cerebellum - diagnostic imaging Cerebellum - metabolism Corpus Striatum - diagnostic imaging Corpus Striatum - metabolism D2 dopamine receptors Dextroamphetamine - administration & dosage Dextroamphetamine - pharmacology Dopamine Dopamine - metabolism Dopamine Antagonists - pharmacokinetics Drug Administration Schedule Drug dosages Female IBZM Injections, Intravenous Iodine Radioisotopes - pharmacokinetics Macaca mulatta Male Males Medical sciences Monkeys & apes Motor Activity - drug effects Neuropharmacology Neurosciences Pharmacology. Drug treatments Primates Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychomotor stimulants Psychopharmacology Pyrrolidines - pharmacokinetics Receptors, Dopamine D2 - analysis Receptors, Dopamine D2 - metabolism Stereotyped behavior Stereotyped Behavior - drug effects Stimulants Striatum Tomography, Emission-Computed, Single-Photon Young adults
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