Behavioral Changes and [123I]IBZM Equilibrium SPECT Measurement of Amphetamine-Induced Dopamine Release in Rhesus Monkeys Exposed to Subchronic Amphetamine
Previously we have shown that twelve weeks of repeated low-dose d-amphetamine (AMPH) exposure in rhesus monkeys induces a long-lasting enhancement of behavioral responses to acute low-dose challenge. The present study was designed to investigate the behavioral and neurochemical consequences of a six...
Gespeichert in:
| Veröffentlicht in: | Neuropsychopharmacology (New York, N.Y.) N.Y.), 2000-01, Vol.22 (1), p.4-13 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 13 |
|---|---|
| container_issue | 1 |
| container_start_page | 4 |
| container_title | Neuropsychopharmacology (New York, N.Y.) |
| container_volume | 22 |
| creator | Castner, Stacy A Al-Tikriti, Mohammed S Baldwin, Ronald M Seibyl, John P Innis, Robert B Goldman-Rakic, Patricia S |
| description | Previously we have shown that twelve weeks of repeated low-dose d-amphetamine (AMPH) exposure in rhesus monkeys induces a long-lasting enhancement of behavioral responses to acute low-dose challenge. The present study was designed to investigate the behavioral and neurochemical consequences of a six-week regimen of low-dose AMPH exposure (0.1–1.0 mg/kg, i.m., b.i.d.) in rhesus monkeys. SPECT imaging of AMPH's (0.4 mg/kg) ability to displace [123I]IBZM bound to D2 dopamine receptors in the striatum of saline control and AMPH-treated animals prior to and following chronic treatment was accomplished using a bolus/constant infusion paradigm. Following chronic AMPH treatment, all monkeys showed an enhanced behavioral response to acute AMPH challenge and a significant decrease in the percent of AMPH-induced displacement of [123I]IBZM in striatum compared to their pretreatment scans. These findings suggest that relatively small changes in presynaptic dopamine function may be reflected in significant alterations in the behavioral response to acute AMPH challenge. |
| doi_str_mv | 10.1016/S0893-133X(99)00080-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_759318186</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0893133X99000809</els_id><sourcerecordid>70855826</sourcerecordid><originalsourceid>FETCH-LOGICAL-c496t-a698cbfcf93b3e2bb050c08df04ca123996d7dbbb7368eef773ca468820ef37f3</originalsourceid><addsrcrecordid>eNqF0V2L1DAUBuAiijuu_gQliPhxUU2aNk2uZHccdWAHZWeFRZGQpqc2a5t0k2Zxf4t_1s4HunihV4HwnJecvEnykOCXBBP2ao25oCmh9Py5EC8wxhyn4lYyI2WOU0bz89vJ7Dc5SO6FcIExKUrG7yYHBDNKc17Mkp_H0Kor47zq0LxV9hsEpGyNvpCMLr8ujz-v0OIyms5U3sQerT8u5mdoBSpEDz3YEbkGHfVDC6PqjYV0aeuooUZv3LC9QKfQTRqQsei0hRADWjn7Ha4DWvwYXJjo6NA6Vrr1zhp9M-x-cqdRXYAH-_Mw-fR2cTZ_n558eLecH52kOhdsTBUTXFeNbgStKGRVhQusMa8bnGs1rSEEq8u6qqqSMg7QlCXVKmecZxgaWjb0MHm2yx28u4wQRtmboKHrlAUXgywLQQknnE3y6b8l5kXBsw18_Be8cNHbaQuZZUWWU8E2qNgh7V0IHho5eNMrfy0JlpuS5bZkuWlQCiG3JUsxzT3ah8eqh_rG1K7VCTzZAxW06hqvrDbhj8soowWf2Osdg-lzrwx4GbQBO9VnPOhR1s785yW_AHqKxMI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>225243966</pqid></control><display><type>article</type><title>Behavioral Changes and [123I]IBZM Equilibrium SPECT Measurement of Amphetamine-Induced Dopamine Release in Rhesus Monkeys Exposed to Subchronic Amphetamine</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><source>SpringerLink Journals - AutoHoldings</source><creator>Castner, Stacy A ; Al-Tikriti, Mohammed S ; Baldwin, Ronald M ; Seibyl, John P ; Innis, Robert B ; Goldman-Rakic, Patricia S</creator><creatorcontrib>Castner, Stacy A ; Al-Tikriti, Mohammed S ; Baldwin, Ronald M ; Seibyl, John P ; Innis, Robert B ; Goldman-Rakic, Patricia S</creatorcontrib><description>Previously we have shown that twelve weeks of repeated low-dose d-amphetamine (AMPH) exposure in rhesus monkeys induces a long-lasting enhancement of behavioral responses to acute low-dose challenge. The present study was designed to investigate the behavioral and neurochemical consequences of a six-week regimen of low-dose AMPH exposure (0.1–1.0 mg/kg, i.m., b.i.d.) in rhesus monkeys. SPECT imaging of AMPH's (0.4 mg/kg) ability to displace [123I]IBZM bound to D2 dopamine receptors in the striatum of saline control and AMPH-treated animals prior to and following chronic treatment was accomplished using a bolus/constant infusion paradigm. Following chronic AMPH treatment, all monkeys showed an enhanced behavioral response to acute AMPH challenge and a significant decrease in the percent of AMPH-induced displacement of [123I]IBZM in striatum compared to their pretreatment scans. These findings suggest that relatively small changes in presynaptic dopamine function may be reflected in significant alterations in the behavioral response to acute AMPH challenge.</description><identifier>ISSN: 0893-133X</identifier><identifier>EISSN: 1740-634X</identifier><identifier>DOI: 10.1016/S0893-133X(99)00080-9</identifier><identifier>PMID: 10633485</identifier><identifier>CODEN: NEROEW</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Amphetamines ; Animal model ; Animals ; Behavioral sensitization ; Benzamides - pharmacokinetics ; Biological and medical sciences ; Cerebellum - diagnostic imaging ; Cerebellum - metabolism ; Corpus Striatum - diagnostic imaging ; Corpus Striatum - metabolism ; D2 dopamine receptors ; Dextroamphetamine - administration & dosage ; Dextroamphetamine - pharmacology ; Dopamine ; Dopamine - metabolism ; Dopamine Antagonists - pharmacokinetics ; Drug Administration Schedule ; Drug dosages ; Female ; IBZM ; Injections, Intravenous ; Iodine Radioisotopes - pharmacokinetics ; Macaca mulatta ; Male ; Males ; Medical sciences ; Monkeys & apes ; Motor Activity - drug effects ; Neuropharmacology ; Neurosciences ; Pharmacology. Drug treatments ; Primates ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychomotor stimulants ; Psychopharmacology ; Pyrrolidines - pharmacokinetics ; Receptors, Dopamine D2 - analysis ; Receptors, Dopamine D2 - metabolism ; Stereotyped behavior ; Stereotyped Behavior - drug effects ; Stimulants ; Striatum ; Tomography, Emission-Computed, Single-Photon ; Young adults</subject><ispartof>Neuropsychopharmacology (New York, N.Y.), 2000-01, Vol.22 (1), p.4-13</ispartof><rights>2000 American College of Neuropsychopharmacology</rights><rights>2000 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Jan 2000</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c496t-a698cbfcf93b3e2bb050c08df04ca123996d7dbbb7368eef773ca468820ef37f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4023,27922,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1236358$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10633485$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Castner, Stacy A</creatorcontrib><creatorcontrib>Al-Tikriti, Mohammed S</creatorcontrib><creatorcontrib>Baldwin, Ronald M</creatorcontrib><creatorcontrib>Seibyl, John P</creatorcontrib><creatorcontrib>Innis, Robert B</creatorcontrib><creatorcontrib>Goldman-Rakic, Patricia S</creatorcontrib><title>Behavioral Changes and [123I]IBZM Equilibrium SPECT Measurement of Amphetamine-Induced Dopamine Release in Rhesus Monkeys Exposed to Subchronic Amphetamine</title><title>Neuropsychopharmacology (New York, N.Y.)</title><addtitle>Neuropsychopharmacology</addtitle><description>Previously we have shown that twelve weeks of repeated low-dose d-amphetamine (AMPH) exposure in rhesus monkeys induces a long-lasting enhancement of behavioral responses to acute low-dose challenge. The present study was designed to investigate the behavioral and neurochemical consequences of a six-week regimen of low-dose AMPH exposure (0.1–1.0 mg/kg, i.m., b.i.d.) in rhesus monkeys. SPECT imaging of AMPH's (0.4 mg/kg) ability to displace [123I]IBZM bound to D2 dopamine receptors in the striatum of saline control and AMPH-treated animals prior to and following chronic treatment was accomplished using a bolus/constant infusion paradigm. Following chronic AMPH treatment, all monkeys showed an enhanced behavioral response to acute AMPH challenge and a significant decrease in the percent of AMPH-induced displacement of [123I]IBZM in striatum compared to their pretreatment scans. These findings suggest that relatively small changes in presynaptic dopamine function may be reflected in significant alterations in the behavioral response to acute AMPH challenge.</description><subject>Amphetamines</subject><subject>Animal model</subject><subject>Animals</subject><subject>Behavioral sensitization</subject><subject>Benzamides - pharmacokinetics</subject><subject>Biological and medical sciences</subject><subject>Cerebellum - diagnostic imaging</subject><subject>Cerebellum - metabolism</subject><subject>Corpus Striatum - diagnostic imaging</subject><subject>Corpus Striatum - metabolism</subject><subject>D2 dopamine receptors</subject><subject>Dextroamphetamine - administration & dosage</subject><subject>Dextroamphetamine - pharmacology</subject><subject>Dopamine</subject><subject>Dopamine - metabolism</subject><subject>Dopamine Antagonists - pharmacokinetics</subject><subject>Drug Administration Schedule</subject><subject>Drug dosages</subject><subject>Female</subject><subject>IBZM</subject><subject>Injections, Intravenous</subject><subject>Iodine Radioisotopes - pharmacokinetics</subject><subject>Macaca mulatta</subject><subject>Male</subject><subject>Males</subject><subject>Medical sciences</subject><subject>Monkeys & apes</subject><subject>Motor Activity - drug effects</subject><subject>Neuropharmacology</subject><subject>Neurosciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Primates</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychomotor stimulants</subject><subject>Psychopharmacology</subject><subject>Pyrrolidines - pharmacokinetics</subject><subject>Receptors, Dopamine D2 - analysis</subject><subject>Receptors, Dopamine D2 - metabolism</subject><subject>Stereotyped behavior</subject><subject>Stereotyped Behavior - drug effects</subject><subject>Stimulants</subject><subject>Striatum</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><subject>Young adults</subject><issn>0893-133X</issn><issn>1740-634X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0V2L1DAUBuAiijuu_gQliPhxUU2aNk2uZHccdWAHZWeFRZGQpqc2a5t0k2Zxf4t_1s4HunihV4HwnJecvEnykOCXBBP2ao25oCmh9Py5EC8wxhyn4lYyI2WOU0bz89vJ7Dc5SO6FcIExKUrG7yYHBDNKc17Mkp_H0Kor47zq0LxV9hsEpGyNvpCMLr8ujz-v0OIyms5U3sQerT8u5mdoBSpEDz3YEbkGHfVDC6PqjYV0aeuooUZv3LC9QKfQTRqQsei0hRADWjn7Ha4DWvwYXJjo6NA6Vrr1zhp9M-x-cqdRXYAH-_Mw-fR2cTZ_n558eLecH52kOhdsTBUTXFeNbgStKGRVhQusMa8bnGs1rSEEq8u6qqqSMg7QlCXVKmecZxgaWjb0MHm2yx28u4wQRtmboKHrlAUXgywLQQknnE3y6b8l5kXBsw18_Be8cNHbaQuZZUWWU8E2qNgh7V0IHho5eNMrfy0JlpuS5bZkuWlQCiG3JUsxzT3ah8eqh_rG1K7VCTzZAxW06hqvrDbhj8soowWf2Osdg-lzrwx4GbQBO9VnPOhR1s785yW_AHqKxMI</recordid><startdate>200001</startdate><enddate>200001</enddate><creator>Castner, Stacy A</creator><creator>Al-Tikriti, Mohammed S</creator><creator>Baldwin, Ronald M</creator><creator>Seibyl, John P</creator><creator>Innis, Robert B</creator><creator>Goldman-Rakic, Patricia S</creator><general>Elsevier Inc</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>200001</creationdate><title>Behavioral Changes and [123I]IBZM Equilibrium SPECT Measurement of Amphetamine-Induced Dopamine Release in Rhesus Monkeys Exposed to Subchronic Amphetamine</title><author>Castner, Stacy A ; Al-Tikriti, Mohammed S ; Baldwin, Ronald M ; Seibyl, John P ; Innis, Robert B ; Goldman-Rakic, Patricia S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c496t-a698cbfcf93b3e2bb050c08df04ca123996d7dbbb7368eef773ca468820ef37f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Amphetamines</topic><topic>Animal model</topic><topic>Animals</topic><topic>Behavioral sensitization</topic><topic>Benzamides - pharmacokinetics</topic><topic>Biological and medical sciences</topic><topic>Cerebellum - diagnostic imaging</topic><topic>Cerebellum - metabolism</topic><topic>Corpus Striatum - diagnostic imaging</topic><topic>Corpus Striatum - metabolism</topic><topic>D2 dopamine receptors</topic><topic>Dextroamphetamine - administration & dosage</topic><topic>Dextroamphetamine - pharmacology</topic><topic>Dopamine</topic><topic>Dopamine - metabolism</topic><topic>Dopamine Antagonists - pharmacokinetics</topic><topic>Drug Administration Schedule</topic><topic>Drug dosages</topic><topic>Female</topic><topic>IBZM</topic><topic>Injections, Intravenous</topic><topic>Iodine Radioisotopes - pharmacokinetics</topic><topic>Macaca mulatta</topic><topic>Male</topic><topic>Males</topic><topic>Medical sciences</topic><topic>Monkeys & apes</topic><topic>Motor Activity - drug effects</topic><topic>Neuropharmacology</topic><topic>Neurosciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Primates</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychomotor stimulants</topic><topic>Psychopharmacology</topic><topic>Pyrrolidines - pharmacokinetics</topic><topic>Receptors, Dopamine D2 - analysis</topic><topic>Receptors, Dopamine D2 - metabolism</topic><topic>Stereotyped behavior</topic><topic>Stereotyped Behavior - drug effects</topic><topic>Stimulants</topic><topic>Striatum</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Castner, Stacy A</creatorcontrib><creatorcontrib>Al-Tikriti, Mohammed S</creatorcontrib><creatorcontrib>Baldwin, Ronald M</creatorcontrib><creatorcontrib>Seibyl, John P</creatorcontrib><creatorcontrib>Innis, Robert B</creatorcontrib><creatorcontrib>Goldman-Rakic, Patricia S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Neuropsychopharmacology (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Castner, Stacy A</au><au>Al-Tikriti, Mohammed S</au><au>Baldwin, Ronald M</au><au>Seibyl, John P</au><au>Innis, Robert B</au><au>Goldman-Rakic, Patricia S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Behavioral Changes and [123I]IBZM Equilibrium SPECT Measurement of Amphetamine-Induced Dopamine Release in Rhesus Monkeys Exposed to Subchronic Amphetamine</atitle><jtitle>Neuropsychopharmacology (New York, N.Y.)</jtitle><addtitle>Neuropsychopharmacology</addtitle><date>2000-01</date><risdate>2000</risdate><volume>22</volume><issue>1</issue><spage>4</spage><epage>13</epage><pages>4-13</pages><issn>0893-133X</issn><eissn>1740-634X</eissn><coden>NEROEW</coden><abstract>Previously we have shown that twelve weeks of repeated low-dose d-amphetamine (AMPH) exposure in rhesus monkeys induces a long-lasting enhancement of behavioral responses to acute low-dose challenge. The present study was designed to investigate the behavioral and neurochemical consequences of a six-week regimen of low-dose AMPH exposure (0.1–1.0 mg/kg, i.m., b.i.d.) in rhesus monkeys. SPECT imaging of AMPH's (0.4 mg/kg) ability to displace [123I]IBZM bound to D2 dopamine receptors in the striatum of saline control and AMPH-treated animals prior to and following chronic treatment was accomplished using a bolus/constant infusion paradigm. Following chronic AMPH treatment, all monkeys showed an enhanced behavioral response to acute AMPH challenge and a significant decrease in the percent of AMPH-induced displacement of [123I]IBZM in striatum compared to their pretreatment scans. These findings suggest that relatively small changes in presynaptic dopamine function may be reflected in significant alterations in the behavioral response to acute AMPH challenge.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>10633485</pmid><doi>10.1016/S0893-133X(99)00080-9</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0893-133X |
| ispartof | Neuropsychopharmacology (New York, N.Y.), 2000-01, Vol.22 (1), p.4-13 |
| issn | 0893-133X 1740-634X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_759318186 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; SpringerLink Journals - AutoHoldings |
| subjects | Amphetamines Animal model Animals Behavioral sensitization Benzamides - pharmacokinetics Biological and medical sciences Cerebellum - diagnostic imaging Cerebellum - metabolism Corpus Striatum - diagnostic imaging Corpus Striatum - metabolism D2 dopamine receptors Dextroamphetamine - administration & dosage Dextroamphetamine - pharmacology Dopamine Dopamine - metabolism Dopamine Antagonists - pharmacokinetics Drug Administration Schedule Drug dosages Female IBZM Injections, Intravenous Iodine Radioisotopes - pharmacokinetics Macaca mulatta Male Males Medical sciences Monkeys & apes Motor Activity - drug effects Neuropharmacology Neurosciences Pharmacology. Drug treatments Primates Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychomotor stimulants Psychopharmacology Pyrrolidines - pharmacokinetics Receptors, Dopamine D2 - analysis Receptors, Dopamine D2 - metabolism Stereotyped behavior Stereotyped Behavior - drug effects Stimulants Striatum Tomography, Emission-Computed, Single-Photon Young adults |
| title | Behavioral Changes and [123I]IBZM Equilibrium SPECT Measurement of Amphetamine-Induced Dopamine Release in Rhesus Monkeys Exposed to Subchronic Amphetamine |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T16%3A51%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Behavioral%20Changes%20and%20%5B123I%5DIBZM%20Equilibrium%20SPECT%20Measurement%20of%20Amphetamine-Induced%20Dopamine%20Release%20in%20Rhesus%20Monkeys%20Exposed%20to%20Subchronic%20Amphetamine&rft.jtitle=Neuropsychopharmacology%20(New%20York,%20N.Y.)&rft.au=Castner,%20Stacy%20A&rft.date=2000-01&rft.volume=22&rft.issue=1&rft.spage=4&rft.epage=13&rft.pages=4-13&rft.issn=0893-133X&rft.eissn=1740-634X&rft.coden=NEROEW&rft_id=info:doi/10.1016/S0893-133X(99)00080-9&rft_dat=%3Cproquest_cross%3E70855826%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=225243966&rft_id=info:pmid/10633485&rft_els_id=S0893133X99000809&rfr_iscdi=true |